ID   M4A6J0_XIPMA            Unreviewed;       822 AA.
AC   M4A6J0;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   SubName: Full=Sortilin-like {ECO:0000313|Ensembl:ENSXMAP00000010084.1};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000010084.1, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX   PubMed=23542700; DOI=10.1038/ng.2604;
RA   Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA   Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA   Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA   Postlethwait J.H., Warren W.C.;
RT   "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT   evolutionary adaptation and several complex traits.";
RL   Nat. Genet. 45:567-572(2013).
RN   [3] {ECO:0000313|Ensembl:ENSXMAP00000010084.1}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000010084.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_005801394.1; XM_005801337.2.
DR   AlphaFoldDB; M4A6J0; -.
DR   Ensembl; ENSXMAT00000010098.2; ENSXMAP00000010084.1; ENSXMAG00000010054.2.
DR   GeneID; 102237523; -.
DR   KEGG; xma:102237523; -.
DR   CTD; 799153; -.
DR   eggNOG; KOG3511; Eukaryota.
DR   GeneTree; ENSGT01030000234563; -.
DR   HOGENOM; CLU_013596_0_0_1; -.
DR   OrthoDB; 5840at2759; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.10.70.80; -; 1.
DR   Gene3D; 3.30.60.270; -; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR031777; Sortilin_C.
DR   InterPro; IPR031778; Sortilin_N.
DR   InterPro; IPR006581; VPS10.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR12106:SF44; SORTILIN 1B PRECURSOR; 1.
DR   PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR   Pfam; PF15902; Sortilin-Vps10; 1.
DR   Pfam; PF15901; Sortilin_C; 1.
DR   SMART; SM00602; VPS10; 1.
DR   SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..822
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004047202"
FT   TRANSMEM        746..767
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          122..732
FT                   /note="VPS10"
FT                   /evidence="ECO:0000259|SMART:SM00602"
FT   REGION          51..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          794..822
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   822 AA;  90876 MW;  E6FA56CD92EB4DDD CRC64;
     MGLLLHCLLL LAVCALPAGG LDFQPGSKAL GQPVFVRRSV ERRAAQIAKR SLPSWPGASH
     HHRIRRRSVD QGESCKKHEG YQSKLKDNTH SYTLNDLSGS VSLAWVGDGT GVILALTTFQ
     VPIFLLRFGQ SKLYRSEDYG KSFEDVTNLI NNTFISAEFG IAIGPENSGK VILTAEISGG
     DGYRIFASSD FGKTFAHLNL PFNPMMQISY NPENSNVLAV LSMRNELWLS EDFGRNWKKI
     SDMVCLFKWG RKNTIFFTSS QNGSCSDRGM LQLKRTTDLG KTIKTVASKI FSFGLGGRFL
     FASVMTGKGT MRMIHVSVDQ GENWNMAQLP PVGHEQFYSI LAANDDMVFM HVDEPGDTGF
     GTIYVSDDRG TVYSKSLERH LYTTTGGDTD FTNVTSLRGV FITSVLAEDT SVQSVVSFDQ
     GGEWVPLQRP ANTKCDATAK DPDKCSLHIH AAYSIAMKLD VPMPPLTEPN AVGLIIAHGS
     VGDAISVMKS DVYVSDDGGY TWIKALNGPH HYAMLDSGGL LVAVEDNGKP INKIKFSTDE
     GQCWSIYEFT KEPISFTGLA SEPGARSMNV SIWGYKDSLI TQNWVSFTID FRELLTRDCN
     DDDYVQWLAH SDDISDPTDG CMLGYKETFL RLRKDSVCWN GRDYTVNTQP TPCACTLDDF
     LCDFGYSRKE NSSECVEQPD LQGKVLEFCL HGKEEQLQTK GYRKIPGDKC EGGQMPQRKE
     IDLSKRCVSD LVSPELQTDG HSSKSVAILL AVVVVMLLSV AAGVVFVRKY VCGGRFLVHR
     YSVLQQHVED NAADGIDEPL DTNHAPNGKI EFHDDSDEDL LE
//