ID M4A955_XIPMA Unreviewed; 2106 AA.
AC M4A955;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Mediator of DNA damage checkpoint protein 1 {ECO:0000256|ARBA:ARBA00015014};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000010999.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000010999.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000010999.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
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DR STRING; 8083.ENSXMAP00000010999; -.
DR Ensembl; ENSXMAT00000011013.2; ENSXMAP00000010999.1; ENSXMAG00000010974.2.
DR eggNOG; KOG2043; Eukaryota.
DR GeneTree; ENSGT00940000161757; -.
DR HOGENOM; CLU_237557_0_0_1; -.
DR InParanoid; M4A955; -.
DR OMA; MAPTQII; -.
DR OrthoDB; 19990at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR CDD; cd17744; BRCT_MDC1_rpt1; 1.
DR CDD; cd18441; BRCT_MDC1_rpt2; 1.
DR CDD; cd22665; FHA_MDC1; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR23196:SF1; MEDIATOR OF DNA DAMAGE CHECKPOINT PROTEIN 1; 1.
DR PANTHER; PTHR23196; PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN; 1.
DR Pfam; PF16589; BRCT_2; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF16770; RTT107_BRCT_5; 1.
DR SMART; SM00292; BRCT; 2.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50172; BRCT; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 53..114
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 1897..1975
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 141..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 194..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 534..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 682..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 785..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1075..1890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2086..2106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..325
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..360
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..392
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..486
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..708
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..825
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..848
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 919..933
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..983
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 984..999
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1017
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1020..1052
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1100..1167
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1183..1233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1259..1273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1287..1335
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1336..1369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1384..1402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1403..1532
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1558..1581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1582..1603
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1649..1670
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1690..1709
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1711..1728
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1736..1772
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1783..1798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1826..1890
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2106 AA; 231909 MW; 1D09D1FA3FEA9CE1 CRC64;
MDATQAISDS ILESEEEDQE KIQNESRKPL AKLCILNNKH IPEKELPLFL GHNFLGRDPN
FCTIQLLAPS VSKQHAAISI SVHRRRGRVH EVDMEALVWD QKSTNGTRKG RLKLTPNVRY
ALNEGDSLVL GDIPCRYVSS GMDSPSSLGD METPRQSEAN ARLSDWDDVD TGSKKCVSRG
TKAKRIPVTG SCLSFEKTPV QPQGSLVPES DSESESEREG RGNRKQKDVV SASDSHNSAF
LSPQSKVVPE SEDESPITPS SSNRNGSSRR ISFSLEKTDI DLEKNKSPVF AENGVEEGEG
AAEGGMYSEE RGDNVKREAD KSPTESSESL RSTLQVSRDA VPEFNLDSDT DVEGEEEEEV
PAGKSDQCPN TVLSHMDSDT DVNEDVSDKA PRTSPSTDEA TKCSVATGIQ FEGITVDSDT
DVDGDDDANV TSKAVLPQGV HSADSAPSVQ SVDFNLDSDT DVDEEEEVGK WGNPKTLSEK
SDKPLSPHNL HPNSHTCDKE VTAAGLDILS ESDTDLEEDS LLSVPAAAAD LPVSSAAAAG
APEPESDADT DVDELVAPQP ADEGKPADLR MESDTDVEDE ETSPGEEEQG QIPHLLRENT
AEFPVLLWQN SSTPVHVSGE VEQMETQAFT SPISHPRRYA VPSSLRPALM TSCSDSQEDE
DYTVAETQSF ILQTRSCHKG LNPNRASILK SSAVKQEDRS KRDDSFQLGL SDSSHLQGEV
RENTQAYAAV DGGVNMEDTQ DYEESAENDS SLEATQPYEV EPPRSSEMSK KETCVDLTME
ATQAYIPEPY DEGSDEDEGL NSARTGVASS ALAMAETQPM FSSAEDNEPD CSLEPVKNET
ERHVTDSESV AETQPVFTSD NEESGDEELS AESMKSAEEP KHPLTSSALC LAETQPVCLS
DNEESGDDEE LSAGSLRPSK VETHPNTDAV LSLAETQPLH VSADETEPMD SCGDHENNSE
ILLPRKRKAK QLHIDEEESQ QRTDSGETQP LTPGEDNDDS ESMPSLRKRK AKPLQLEDET
KSLVGSQVSA VECQRSVTCE EEQSSQDFIS TQKRKVKPLH IVDEQTQPLI NCEDEDVLPE
RESKALPLSS AGVPSAEVQT KGRDGKRDGD ESVTYPWKRK EKRLHLEEEE TQPVSASESQ
RKTDETKVSP STKEKGEQTK TKDDNNQQEV KVVNQQTRKR RTTRKQKEQD EDKNKRAENE
NQIKEQKGGK LRGEPEIHKR EELMNEGTSK PHLEDDMQPV AASESQRRID GTKVSPSTEE
TGEQKKNKNE SDQQEVKVVN QQTRGRTTRK QEQDEDKNKS QIKEQRDRKL GGDEKETDRH
EKKELMNEGA SKSQLEEETH PVTVSEISPP NTVKKTNVFD VSSISSSIET RLGEEEEKAQ
CSSHQNRQMK SENKPLPSTR GQRGKTKSKD DNNQEEVEAA NQRTRGRRST KKQDDDEIQR
SDENKSQIKE EGDKEEREHV ETERRKEREG KSKGKPRLKE MKSGSEVEEE KGTSVETTKT
DQEHLASLEK EKQPKESQED KNKEENPKGS ARVRRAARRT TTAVCEALSE DVPARRTRSR
SNSLSSERSV SSINSNTLEN KGRGRGVKKS NEASQRDAVR SSRRRTTTAT AVELEAEAQA
VSASSKVSRG RPQGRGRKSL SQPDVVIKEN EQKATEVLQQ DEKRKADPKL AGTSRGQWRA
TANCSEALVL NDEGLQSNQE KTSADLTSPL PKRNMRDRGA KAVKTEPVEE TEAPTATDGD
ETRNKRKAKT SEEKPEVDRV QKSTEPGGKE EQQEEIPVGI QGRRTSRASS TQVKKNEESL
FTQEVKDGKK AAAGAAGKKA RGRTTVVQKN KNQELQETQT SGSSMELAGN EIESEISVMT
PSRKRRVSSN SSPVAKTPRS SSASPATVSR VRSRSQTYKV LFTGVVDKDG EQVLARLGGA
MARGISDMNC LVTDKVRRTV KFLCAVAKGV PVVTTQWLEK SGKAGSFLSP LDFIVKDLEQ
EKKFSFSLQE SLRTASSRPL LQGYEIHVTK SVQPEPVHMK DIITCSGATF LKKMPAAHKP
RTVVISCEED LRLCGPAVSA SLPVVTAEFI LTGILQQRVD LQTHALSPCA TNPHPAEGRG
RGRKKT
//
