ID M4AAA4_XIPMA Unreviewed; 1185 AA.
AC M4AAA4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Plakophilin 4 {ECO:0000313|Ensembl:ENSXMAP00000011398.2};
GN Name=PKP4 {ECO:0000313|Ensembl:ENSXMAP00000011398.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000011398.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000011398.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000011398.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta-catenin family.
CC {ECO:0000256|ARBA:ARBA00005462}.
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DR Ensembl; ENSXMAT00000011412.2; ENSXMAP00000011398.2; ENSXMAG00000011363.2.
DR Ensembl; ENSXMAT00000025013.1; ENSXMAP00000021606.1; ENSXMAG00000011363.2.
DR eggNOG; KOG1048; Eukaryota.
DR GeneTree; ENSGT00940000155773; -.
DR HOGENOM; CLU_007897_0_0_1; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0098609; P:cell-cell adhesion; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR028435; Plakophilin/d_Catenin.
DR PANTHER; PTHR10372:SF8; PLAKOPHILIN-4; 1.
DR PANTHER; PTHR10372; PLAKOPHILLIN-RELATED; 1.
DR Pfam; PF00514; Arm; 3.
DR SMART; SM00185; ARM; 6.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 3.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT REPEAT 564..591
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 608..651
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 866..903
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 71..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 268..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 767..802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1076..1107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 33..60
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 75..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 767..793
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1076..1091
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1185 AA; 130800 MW; A390355619513BD2 CRC64;
MPAPEQSPVT EEGLLLTIRD SSAGRKMETD NTANNILASV KEQELQFERL TRELEVERQI
VANQLERCRL GAESPGAGSS SSSEKSLPWR TADTSASGDT KSRVTDSSQS PSYRIRAESE
QVSLYSPEQS SLHERSAGNS CGSAQMNSYS DSGYQDASSG YLSRQNQCKA ELKMQHSFPG
AGTGTLLRNA RAEGQASAQV PGVTAALPGR AMRRVSSVPS RSHSPAYASS ISPSRGSLRT
SVGSAYGSPV VTEPKPLSNI HFTTLPSVQR TGSIGSGSPY SPQKTSPAGL RRISSTNSRP
GSTSRTTSPY QTSAGSASGR MGSPLTLVDP PLIKQPTHSS SPVRASMTAV PQHYSSTLPR
SMLHNTDPYG PQSYDIYERM TRPDSLAGIR SSYASQHSHH GQDMRSTISP DRHIAPIYED
RTFRGPLYRS PSHTQQGTLY RSGSGVGSLQ RTSSQRSAMT YQRNNYALNT AANYADPYRS
AQYRPSDSNY ARQTIVMDDG APRSPSIDSI QKDPREFAWR DPELTEVIHM LQHHFPSVQA
NAAAYLQHLC FGDNRVKSEV CRLGGIKHLV DLLDHKTVEV QRNSCGALRN LVYGKAMDEN
KIAVRNAGGI PALLRLLRKT VDAEVRELVT GVLWNLSSCD AVKMTIIRDA LSTLTNTVII
PHSGWSSSTF DDDHKLKFHS SLVLRNTTGC LRNLSSAGEE ARKQMRTCDG LVDSLLYVIK
ACVNTSDFDS KIVENCICTL RNLSYRLELE MMPSSFPVNQ EMDGLLGRES PSKEVDSSCW
GRKRKKKKNS LQEDSWDGVG PIPGFSKSPK GAEMLWHPSV VKPYLTLLAE SSNPATLEGS
AGSLQNLSAG NWKFAAYIRA AVRKEKGLPI LVELLRMDND RVVCSVATAL RNMALDIRNK
ELIGKYAMRD LVNRLPGGNT TLLSDETVAA ICCTLHEVTS KNMENAKALA DTGGIKKLVD
ITKGRGDRYS VKVVKAAAQV LNTLWLYRDL RPIYKKDGWN QNHFITPVST LERDRFKSQP
TLATSTIQMS PVNHPAASAT SSPAMLGIKE HRSSVRDYQR TQSTMQFYNY QGDGSIHRKQ
YTGSGKPSPY YYSSPTREEP RRSQPVYYTE EPSRRNYDTY RMYLQHPHGY DDAYLEEVIT
YPPTADYSSQ PHGLKSTSNY VDYYASTRRP SYRAEQYPGS PDSWV
//
