ID M4AAR5_XIPMA Unreviewed; 4509 AA.
AC M4AAR5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=LDL receptor related protein 1B {ECO:0000313|Ensembl:ENSXMAP00000011559.2};
GN Name=LRP1B {ECO:0000313|Ensembl:ENSXMAP00000011559.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000011559.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000011559.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000011559.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 8083.ENSXMAP00000011559; -.
DR Ensembl; ENSXMAT00000011573.2; ENSXMAP00000011559.2; ENSXMAG00000011528.2.
DR eggNOG; KOG1215; Eukaryota.
DR GeneTree; ENSGT00940000157521; -.
DR HOGENOM; CLU_000423_2_1_1; -.
DR InParanoid; M4AAR5; -.
DR OMA; GRDEFHC; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00112; LDLa; 29.
DR Gene3D; 2.10.25.10; Laminin; 11.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 30.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 8.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722:SF5; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B; 1.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 5.
DR Pfam; PF00057; Ldl_recept_a; 28.
DR Pfam; PF00058; Ldl_recept_b; 8.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 27.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM00192; LDLa; 30.
DR SMART; SM00135; LY; 35.
DR SUPFAM; SSF57196; EGF/Laminin; 7.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF57424; LDL receptor-like module; 29.
DR SUPFAM; SSF63825; YWTD domain; 8.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS01209; LDLRA_1; 15.
DR PROSITE; PS50068; LDLRA_2; 30.
DR PROSITE; PS51120; LDLRB; 19.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 4364..4387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 331..374
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 375..418
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 568..610
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 611..656
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 657..706
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 707..750
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1288..1334
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1335..1377
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1378..1424
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1606..1648
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1693..1732
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1910..1952
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1953..1995
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1996..2039
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2318..2362
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2363..2405
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 2898..2933
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 3029..3071
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3072..3115
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3965..4008
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 4135..4168
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4171..4207
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4208..4243
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4244..4279
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4314..4349
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 839..851
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 846..864
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 880..892
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 887..905
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 921..933
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 928..946
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 940..955
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 968..986
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 980..995
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 999..1011
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1006..1024
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1061..1076
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1104..1119
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2506..2524
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2540..2552
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2547..2565
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2559..2574
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2612..2624
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2619..2637
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2631..2646
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2650..2662
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2657..2675
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2735..2747
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2742..2760
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2775..2787
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2821..2833
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2828..2846
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2840..2855
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2902..2912
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3247..3259
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3254..3272
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3287..3299
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3294..3312
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3306..3321
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3346..3361
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3386..3401
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3406..3418
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3413..3431
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3425..3440
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3445..3457
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3452..3470
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3464..3479
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3483..3495
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3490..3508
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3502..3517
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3525..3537
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3532..3550
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3544..3559
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3583..3598
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3605..3617
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3612..3630
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3667..3682
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3691..3703
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3698..3716
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 4139..4149
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4175..4185
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4197..4206
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4211..4221
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4233..4242
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4247..4257
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4269..4278
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4316..4326
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4320..4337
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4339..4348
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4509 AA; 504305 MW; EB46FF923DFF5501 CRC64;
MFQCSIITSC RIFFYSSPPL SSCHPEPILC DVGEFHCHDQ QICIPEAWLC DGEPDCPDNS
DESDHICAQE VVIRCPLNHI QCIGTRKCIH FNKLCNGARD CDDGYDEGVH CRELLSACHE
LRCRYGCVMT RNGTFCFCAD GFEVGEDGTS CRDHDECAMY GACSQTCMNT YGSYRCSCTE
GYILQPDRIS CRAKQDPGDS HPVLLIGSSN RIVITHLNGT GLQPLRSLSV NGTLALDFQH
TQERVCWALS TESSGQLRCA ATRNLLTIFV MYLFIADVEQ MAIDWLTGNF YFVEHASDKV
FVCNRAGDTC VTILQLDLLN PKGIALDPLM GMLFITDYGN VAKLERCNMD GSNRTRLVDY
KMEQPTAVAL DMIKKLVYWA DAYLDYIDVV DYHGRNRHTI IHGIQVSYVY ALAVFEDYLY
ALHSAPLEES SSVELLQVNR FNITAESRTL ASLGNSRALR VYHKLAQPKV RSHACEMDSY
GKPGGCSQIC LLSGSYKSRS CRCRIGYRLG FDGTSCKKPK NDFFLFYGKG RPGVIRGLDM
NIKSGDEHMV PIEDLVNPRA IDYHAEMGHI YFADTTSFLI GRQNIDGSSR ETILKDELDN
VEGISVDWIG NNLYWTNDGY RKTISVARLE RASQTRKTLL EGNMSHPRAI VVDPLNSWMY
WTDWEEDEVN DSIGRIEKAW MDGSNRRIFV TSNMLWPNGL TLDHSSSTMY WCDAYYDHIE
KIYLNGTGRM VVYRGKELNH PFGISHYRNF IFWTEYMNAS VFQLDLSTGD VTLLRSERPP
LFGLRVYDAQ SQQGENACSV NYGGCSTLCL AIPGGRVCAC ADNQALEKNN VTCSEPTRCK
SDEFQCHNQR CIRASWKCDG DNDCLDGSDE ESHSCYNHTC PDDQFKCNDN RCISKRWLCD
GTNDCSNGED EANTTCSARP CQSDQFACQN GRCIPRGWSC DRENDCGDMS DEISCTFPTC
QPLTEFSCSN GRCISVKWHC DSDDDCGDGS DEVGCMQTCS NTQFQCTSGR CIPADWACDG
DNDCGDFSDE NTTCRGGPAC KNGDEFHCVE DGTCIPERWR CDGDKDCEDG SDEKDCEGTK
RMCDPKAKFT CKDTGKCITK SWVCDGDIDC EDRSDEESCE SSVCKPPKYP CANDSSVCLT
PDKICNGKVD CADRSDEGPI CDMCLVARGG CSHQCTVAPG KGVVCSCPPG LHLDSSNKTC
EAVDYCSRHL KCSQVCEQYK TTVKCSCYSG WILDADGDSC HSIDPFEAFI IFSIRHEIRR
IDLHKRDYSL LVPGLRNTIA LDFHFNRSLL YWTDVVEDKI YRGRLSETGG VAGIEVVVQH
GLATPEGLAV DWITGKLYWI DSNLDQIEVA KLNGEMRTTL IAGGMEHPRA IALDPGQGIL
FWTDWDATFP RIEAASMSGS GRHIVFKDME IGAWPNGLTL DHLEKRIVWT DARSDAIFSA
LYDGTGVIEI LRGHEYLSHP FAVSLFGGNV YWTDWRTNTL ARANKWTGQN VTVIQKTSAQ
PFDLQIFHPS RQPQASNPCE ENDGRGPCSH LCLINYNRSA SCTCPHLMKL SANKQSCYAL
KRFLLYVRRS EIRGVDIDNP YMNVMTALTV PDIDDVTVVD FDAQEERIYW ADIKSQTIKR
VFINGTQLET IISSDIANCR GLALDWLSKN LYWLSSENDE SQINVARFDG SLKTSIIHGI
DKPRCLVVHP AKGKIYWTDG NTINMANMDG SNSKVLHQNQ KDPVGLSIDF TANKLYWISS
ANGTINRCNL DGGGLEVLET LKRVLAKGTA LAVMGGKLWW ADDESAQLGT VTKRDGRNFL
ILRNKTSGVV HMKVYDREGH KGRNSCQVNN GGCSQLCFPT SENTRSCSCT VGYHLRSDRT
SCEGVGSFLL YSIHEGIRGI ALDPNDNSEA LMPITGTLFA VGVDFHAGND TVYWTDMGLN
RISRAKRDQT WREDVITTGI SRVEGIAVDW IAGNLYWTDH GFNLIEISRL NGAYRSVVIS
EGLDQPRAIA VHPQKGYLFW SEWGQNPCIG RSRLDGSDQV TLVNSGIVWP NGISIDFEEN
TLYWCDARTD KIERINLETG ESREIVMSAA NVDLFSVAVF GPYIYWSDRA HSNGSIRRAF
KTDASEDVTM KSGLGVNLKD VTVFNRDREK GTNPCARGNG GCQQLCFHLG SGRRTCSCAH
GRLADDGFAC ERYEGYLLFS ERTILKSIHL SDENDLNSPV QPLENPAFFK NIVALAFDYN
QSKSGTNRIF FSDAHYGNIQ IINDDWAGRY IIAENVGSVE GLAYHRAWDT LYWTSSTTST
ISRQTVDQNR VGAFSRQAVV TLSEEDHPHV LALDECQSLM FWTNWNEQRP SIMRSTLVGK
NIRIIISSDI LTPNGLTIDH KAEKLYFSDG SLGKIERCDY DGSSRYVILK SGPGNFYGLA
IYADFIYWSD WARRAVLRSN KYTGADTKVL RADIPHQPMG IIVVAKDTNN CELSPCRHMN
GGCGDLCLLT AHGRVNCTCR GERVLLDDNR CVSENSSCNI YTEFECGNGE CIDYQLTCDG
VAHCKDKSDE KMQYCDNRTC RRGFRSCYNQ RCVASGRFCD GIDDCGDNSD EAFCSNSRFF
LTWEMIMTSI IAKAQRIDLI LLYAPVSHGQ KCEEGHFACP SGNCISSVWL CDGQKDCEDG
ADEFQCDSSC LWNQFACSKN KCIAKQWLCD GENDCEDGLD ESVQICGTVT CAPGLFSCPG
SYACVPKRWL CDGERDCPDG SDELSPAGCA PNNTCDDNSF RCHNKACIPQ RFVCDHDNDC
GDGSDESVEC VYRSCGSGEF RCGDGRCLLS SQWECDGYAD CPDHSDELPL NLKCLAAGSL
CNGSFFMCSN GRCISQGNLC DGKDDCGDGS DERNCNVNEC LNRRVSGCTQ DCQDLTVGYK
CKCWPGFHLK DDGKTCVDVD ECSTTLPCSQ RCINTYGSYR CLCVDGYEPV DRNPNTCKAI
SAEEPFLIMA DHHEIRKLSV DGSNYTILKQ GLYNIIHLDF DYKKEFIYWV DSTRPSGRKI
NRMRLNGSDL KIVHRTAVPS ALAVDWIGKN LYWCDAEKKT LEVSKANGLY PTILISSGLK
NPTDLALDPQ TGYVFWVDCC EPSQIGRIGM DGRGQMVIID TEIYSPTALT IDYTNKRLYW
ADDNHILFAN MDGTQRRKVS YDHIQGVMAL TLFEDFVYWT DGKSKSLRRA HKTTGTQAIE
LLNSWQAIKS IKVYHSLRQP EVPKHQCQIA NGGCSHLCLL SPGGEHKCAC PTNFYLAADN
KTCLSNCTSS QFRCGTDECI PFWWKCDTVD DCGDGSDEPP DCPEFKCQPG RFQCGTGLCA
LPPFICDGEN DCGDNTDEAN CETYICLSGQ FKCTRKQKCI PLNLRCNGQD DCGDGEDETD
CPESTCSPDQ FQCKASMHCI SKLWVCDEDP DCADGSDEAN CDEKTCGPHE FRCENNNCIP
DHWRCDSQND CGDGSDEENC KPVTCNHKDF ACANGECISS RFRCDGDYDC LDNSDERGCE
ARCADDQFRC HNNLCISLKW LCDGQEDCKM GEDEKNCHGT VGPSCSVNEY VCASGGCVSA
SLRCDGHDNC LDGSDEIGCV KECREDEFLC LNRAHCIPRR WRCDDVLDCM DHSDEENCNH
GTFFCRADEF ICNNTLCKLH TWVCDGKDDC GDNSDEDAEM CAKLPCPPTR PFRCRNDHVC
LRMDQVCNKV DDCGDNSDEE ECGELRKPRP CGKTEFTCSN QRCIPMQLQC DLFNDCGDGG
SDEQDCKSYV CGKKTNPCGE DAICNQTNAN AICQCKPGFK RNQKTGQCEE MNECLQFDTC
PHYCTNTKGS YKCTCDRNYK EMNGNCVVKG QDDRVLYIAN DTEIRSFVYP YNQSQGHKLL
THIEDNARII GMDVLFHQQK FIWATQFNPG GIFYKDTLER GQTKANVKNI CSDFRRPRDI
SADWITGNIY WTDHSRMHWF SYYTAHWTKL RYSINVGQLK GPNCTRLITD IAGEPYAITV
NPARGMMYWS VIGDHSQIEE SAMDGSLRRV LLEKNLRRPT GLAIDYFNQR IYWADPELSQ
IGSMRLDGSD PLVTIRISQP YRIDLFEDYI YGTGLKHELF KIHKYGKQAV EILYLGVERP
TNVFVAHRYK QQDASNPCLR MSCDFMCLPN PTGARCICPE GKVLVNGTCN DINNSGELCR
PPCENGGRCL ANEKGDWRCY CWPDFSGERC EVNHCTDYCL NGGTCMGSPL GKPTCRCPIG
YSGPFCEKRI CDNYCLNGGT CDVTQGNQPV CRCMAEYTGD RCLYHICHHY CVNSKACTLS
SSGYVECVCP ARYEGNKCEV DKCLRCHGAP CLINEETLDV VCNCTNGRIA PSCQLCDGYC
YNGGTCHLDP DTSLPFCQCS ANWAGTQCER PAPKSSRSDN TRSIAIIVPL VLLVILIVMV
VAGVYICRRR QRGKRVQRQP MTNGGINVEI GNPSYNMYEV DHDNHADAGS LLRPNFTLDP
HKLIITLKLI IEHPQAPIFV NGYPMNYSNP VYAKIYIDGQ NCRKPVISID ERRELLPKKL
EGTIRETAA
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