ID M4AB30_XIPMA Unreviewed; 1741 AA.
AC M4AB30;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000011674.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000011674.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000011674.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR STRING; 8083.ENSXMAP00000011674; -.
DR Ensembl; ENSXMAT00000011688.2; ENSXMAP00000011674.2; ENSXMAG00000011587.2.
DR eggNOG; KOG2301; Eukaryota.
DR GeneTree; ENSGT00940000154992; -.
DR HOGENOM; CLU_000540_5_0_1; -.
DR InParanoid; M4AB30; -.
DR OMA; IIMAYVT; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF292; SODIUM CHANNEL PROTEIN; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 2.
DR PRINTS; PR00170; NACHANNEL.
DR SMART; SM00015; IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 99..122
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 167..186
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 198..219
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 225..248
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 365..392
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 540..558
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 570..593
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 650..678
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 738..763
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 934..953
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 974..990
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1002..1021
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1066..1086
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1173..1196
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1255..1273
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1285..1307
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1319..1338
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1359..1380
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1386..1408
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1476..1499
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 106..398
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 539..770
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 777..889
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 901..929
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 933..1204
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1254..1509
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 32..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1699..1741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1699..1729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1741 AA; 198748 MW; BEE2B2610A848C01 CRC64;
MAATLLPTGP DGLRRFTRES LAALERRVAE EQAKSSKDCT EAQKNAEAAK PRADLEAGKQ
LPRIFGDVPP ELVGVPLEDI DPFYYKNQKT FIVLNKGKAI FRFSATYFIM FTILTNCFFM
AMSDPPTWTK YLEYTFTGIY TFESAIKIFA RGFCLVPFTF LRDPWNWLDF IVIIMAYVTE
FVDLGNVSAL RTFRVLRALK TISVIPGLKT IVGALIQSVR KLADVMILTV FCLSVFALIG
LQLFMGLLRQ KCVRNLDHCI NSSYTPNTTF ICNNRTWSSP DDFLTNEDNF YKVEGQKDAL
ICGYGSDAGK CPDGFDCLKV GKNPNYDYTS FDTFGWAFLA LFRLMTQDYW EELFHQTLRS
AGKTYMVFFV LVIFLGSFYL VNLILAVVAM AYEEQNQATI AEAWQKEREF QLAMEHLRRE
QRENNQLRNC QLEPQKKTSL SIDQNNISDD IYLFLVCQKP CSGADPAPRP LLQPSPSVTE
RCSVRRKRAH SSFSFFKLEE SRQKCPPCWY AFAKKYLIWD CCPWWLKLKE CVKFMVMDPF
LDLGITICIV LNTLFMALEH YPMTDEFNTM LSVGNLVFTG IFTAEMVLKL VALDPYYYFQ
QGWNIFDGVI VCLSLMELGL STVEGLSVLR SFRLLRVFKL AKSWPTLNTL IKIIGNSVGA
LGNLTLVLAI IVFIFAVVGM QLFGKNYQDC VCKIAFDCQL PRWHMKDFFH SFLIVFRVLC
GEWIETMWDC MEVAGQPLCI LVFMLVMVIG NLVVLNLFLA LLLSSFSSDN LSAPEEDGDL
NNIQVAIGRV HTGLSWLCGS IVNLFRHGFR SQKQKAKEAV QAEKMVGNHI ESNGGIIGSY
GEKYILPEED SYMTNPNLTV VVPIAPGESD VEFLEEENSE SSEDEDNKPV NSDSLAFYIL
CLRHCPCCDI DTSRGLGQAW WRLRKTCYQI VEHSWFETFI IFMILLSSGA LAFEDIYIER
RKVIKVMLEY ADKVFSYIFV LEMFLKWIAY GFKKYFTNYW CWLDFLIVDV SLISLVANSL
GYSDFSAIKS LRTLRALRPL RALSRFEGMR VVVNALIGAI PSIMNVLLVC LIFWLIFSIM
GVNLFAGKFG KCVNRTGFIH SISVVNNKSD CLAMNDTQFY WTKVKVNFDN VGLGYLSLLQ
VATFKGWMEI MNAAVDSRGV EEQPSREINL YMYIYFVVFI IFGSFFTLNL FIGVIIDNFN
QQKRKISGQD IFMTEEQKKY YNAMKKLGSK KPQKPIPRPA NILQAFFFDL VSKQAFDIMI
MMLIIVNMVT MMVETDEQSE RMESVLNIIN LVFIVIFTTE CLIKLFALRC YFFTVAWNIF
DFVVIILSII GIVLADIIEK YFVSPTLFRV IRLARIGRVL RLIRAAKGIR TLLFALMMSM
PALFNIGLLL FLVMFIYAIF GMANFAYVKK QDGIDDMFNF ETFGNSIICL FQISTSAGWD
NLLSPIMSSP PEECDINFIN TGTNARGNCG NPSVGIAFFV SYIIISFLIV VNMYIAIILE
NFSVATEEST EPLSEDDFEM FYEVWEKFDS EATQFIEFSM LERFADALSE PLRIAKPNKI
QLISMDLPMV SGDKIHCLDI LFAFTKRVLG ESGDMDTLKQ QMEEKFMMTN PSKVSHEPIT
STLRRKMEEV SVVIIQRCYR RHLVRRQMKQ ASYIYRQINY ETVVDVDNAP ETEGLIASMI
QHFAPVAIQV KQTVEDSLLS SPPSYDSVTR GAGVSPSATV RTASRGPEAQ DPTENYEETF
L
//
