ID M4AB50_XIPMA Unreviewed; 1728 AA.
AC M4AB50;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Kinesin-like protein KIF13B {ECO:0000313|Ensembl:ENSXMAP00000011694.2};
GN Name=KIF13B {ECO:0000313|Ensembl:ENSXMAP00000011694.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000011694.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000011694.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000011694.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR STRING; 8083.ENSXMAP00000011694; -.
DR Ensembl; ENSXMAT00000011708.2; ENSXMAP00000011694.2; ENSXMAG00000011641.2.
DR eggNOG; KOG0241; Eukaryota.
DR GeneTree; ENSGT00940000155500; -.
DR HOGENOM; CLU_001485_29_2_1; -.
DR InParanoid; M4AB50; -.
DR OMA; LVCSIKI; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF3; KINESIN FAMILY MEMBER 14-LIKE; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF01302; CAP_GLY; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM01052; CAP_GLY; 1.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF74924; Cap-Gly domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS00845; CAP_GLY_1; 1.
DR PROSITE; PS50245; CAP_GLY_2; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 10..350
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 1642..1684
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
FT REGION 545..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1364..1389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1450..1514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1531..1567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 608..640
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 560..576
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1370..1389
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1487..1501
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1531..1562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 100..107
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1728 AA; 192970 MW; B153C571761A716B CRC64;
MGEPSLDDSN VKVAVRVRPM NRREKELNTK CVVEMAKNQT ILHPAGANLG KVFAYDYCFW
SMDETDKEKF AGQEVVFQCL GESLLHNAFQ GYNACIFAYG QTGSGKSYTM MGSGDQPGLI
PRLCSALFER TKEEQREEES FTVEVSYMEI YNEKVRDLLD PKGGRQALRV REHKVLGPYV
DGLSRLAVAS YKDIESLMSE GNKSRTVAAT NMNEESSRSH AVFNIILTHT LKDLRSGTSG
EKVSRLSLVD LAGSERAAKT GAAGERLKEG SNINKSLTTL GLVISALAEQ GTAKNKTKFV
PYRDSVLTWL LKDCLGGNSR TAMVATVSPA ADNYEETLST LRYADRAKNI VNHAVVNEDP
NARIIRELRE EVEKLRVQLT QAESMKAPEL KERLEESEKL IQEMTYTWEE KLRKTEEIAQ
ERQKQLESLG ISLQSSGIKV GDDKSFLVNL NADPALNELL VYYLKEHTRV GSADSQDIQL
CGMGIQAEHC VIDTTAETAV ILTPHPNART CVNGSPVTTA LQLHHGDRIL WGNNHFFRIN
LAKRRSRPAE EEEGEGGVLK NSGSSEQLDA DGDTASEVSS EVSFSYEFAQ TEVMMKALGS
NDPMQAVLQS LERQHEEEKR SALERQRQMY EQELQQLRKK LNPDRLSTGQ GQQSHYRSLE
RLSVGGMSHS TSAQSRLRQW SEDREVVLVR SLRRLREQIV RANLLVQEAC FISDELERHT
EYRVTLQIPS DNLNANRKRD AVLSEPAIQV RRRCRGKQIW SLEKMENRLV DMRELYQEWQ
DYHVMRSYFR RADPFFDEQE NHSLIGVANV FLSCLFYDVK LQYAVPIINQ KGEVAGRLHV
EVMRVGGGLE DNMAGGDEPD NNQDSEFEDR KLVCSIKILQ ATGLPQHLSN FVFCQYSFWD
QSEPTIVAPE VDPSSSSPNS KDPHCMVVFD SCKEVAVSVT EDFIEYLTEG AVAIEVFGHK
QSDAGRNPAL WDLSIIQAKT RTLRDRWSEV TRRLELWIQI LEINENGDFV PVEVVPARDV
STGGIFQLRQ GQSRRVQVDV RSVQDSGTMP LIAEIVLAVS VGCVEIRTST ANQEGDEMDS
YQDRDLERLR RQWLAALTKR QEYLDQHLQS LVSKAEKTED DMEREAQLLE WRLTLTEERN
AVMVPSAGSG IPGAPAECAG CPNVTLVSHQ TYIFSFPPAD DFNSHEQFEV PEAGGWDAML
TGEDEDDFFD LQIVKHYDGE VKAEASWDST VHECPQLSRG GSWPEQRVYL TVRAVVQLSH
PADMQLVLRK RICVNVNPGR QGFAHNFLRR MSTRSTIPGC GVTFEVVSNI PGDREMLARL
AASAHNSQSG DDEAAIEKYL RSVMSLENIL TLDRLRQEVA VKEQLTGKGR SNRRSLSSPS
VHRLSGSRQD LSTSCLLDDK GRWESQQDIF MPTHRTLPRR LGLAASYLSV KALVPQMPKL
LKSLFPARDD KKELRPSPHG QQHVPRIVAS TGGDDSRGKP ETVRDPYEFP DVPPLPVHDP
HDTTPLSPLS QSSSGYFSAS VSTVTLSDVL QPSSSSSSLL GADAASPSNP QQQQQGADRN
DVVTSPPQCG AKMAVAASNH NNSIPAELSF SNQKLVEGFE RLEIFVDDGD GRGHDDVPPD
WLAEGAYVTV GSNKAGTVRY VGTTQFADGV WVGVELDTPI GKNDGSVGGH RYFLCKPGYG
VLVRPDRLSR RDRAARRTTD VAQPAHVPVL RGEAIIARRG ENRKSWSN
//
