ID M4ABB0_XIPMA Unreviewed; 1213 AA.
AC M4ABB0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Cohesin subunit SA {ECO:0000256|RuleBase:RU369063};
DE AltName: Full=SCC3 homolog {ECO:0000256|RuleBase:RU369063};
DE AltName: Full=Stromal antigen {ECO:0000256|RuleBase:RU369063};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000011754.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000011754.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000011754.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of cohesin complex, a complex required for the
CC cohesion of sister chromatids after DNA replication. The cohesin
CC complex apparently forms a large proteinaceous ring within which sister
CC chromatids can be trapped. At anaphase, the complex is cleaved and
CC dissociates from chromatin, allowing sister chromatids to segregate.
CC {ECO:0000256|RuleBase:RU369063}.
CC -!- SUBUNIT: Part of the cohesin complex which is composed of a heterodimer
CC between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached
CC via their hinge domain, and RAD21 which link them at their heads, and
CC one STAG protein. {ECO:0000256|RuleBase:RU369063}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369063}.
CC Chromosome {ECO:0000256|RuleBase:RU369063}. Chromosome, centromere
CC {ECO:0000256|RuleBase:RU369063}.
CC -!- SIMILARITY: Belongs to the SCC3 family. {ECO:0000256|ARBA:ARBA00005486,
CC ECO:0000256|RuleBase:RU369063}.
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DR AlphaFoldDB; M4ABB0; -.
DR Ensembl; ENSXMAT00000011770.2; ENSXMAP00000011754.2; ENSXMAG00000011653.2.
DR eggNOG; KOG2011; Eukaryota.
DR GeneTree; ENSGT00950000182972; -.
DR HOGENOM; CLU_005067_1_0_1; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IEA:UniProtKB-UniRule.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0008278; C:cohesin complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:UniProtKB-UniRule.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039662; Cohesin_Scc3/SA.
DR InterPro; IPR020839; SCD.
DR InterPro; IPR013721; STAG.
DR PANTHER; PTHR11199:SF3; COHESIN SUBUNIT SA-2; 1.
DR PANTHER; PTHR11199; STROMAL ANTIGEN; 1.
DR Pfam; PF21581; SCD; 1.
DR Pfam; PF08514; STAG; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51425; SCD; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|RuleBase:RU369063};
KW Cell division {ECO:0000256|RuleBase:RU369063};
KW Chromosome {ECO:0000256|RuleBase:RU369063};
KW Chromosome partition {ECO:0000256|RuleBase:RU369063};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|RuleBase:RU369063};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 224..309
FT /note="SCD"
FT /evidence="ECO:0000259|PROSITE:PS51425"
FT COILED 165..218
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1213 AA; 139549 MW; 099B04FA4F6C42DD CRC64;
VNGHHQENGT DNMSLFEVVK MGRSATQSVV DEWIEAYKQD RDVALLELIN FFIQCSGCKG
AVSEEMFRHM QNSEIIRKMT EEFDEDSGDY PLTLSGPQWK RFRINFCDFI AVLVRQCQYS
IIYDEYMMDT VISLLTGLSD SQVRAFRHTS TLAAMKLMTA LVNVALNLSI NMDNTQRQYE
AERNKVIAKR ANDRLELLLQ KRKELQENQD DIENMMNAIF KGVFVHRYRD AIAEIRAICI
EEIGVWMKLY SDAFLNDSYL KYVGWTMHDK QGEVRLKCLT ALQGLFYSRE LGSRLELFTS
RFKDRIVSMT LDKEYDVAVQ AIKLLTLILQ SSDEVLTAED CESVYHLVYS AHRPIAVSAG
EFLFKKLFSH QGPEDEGLPR RGRQSLNGSL IKTTVFFFLE SELHEHGAYL VDSLWECASE
LLKDWETMIS LLLDEPMPGE EALTDRQETA LVEIMLSAIR QACECHPPVG RGSGKRVLTA
KEKKTQLDDR TRTTEMFAVA LPLLLAKYCV DIDKVTSLLQ IPKYFDLDIY TTGRLEKHMD
ALLRQIWEVV DKHTDTEVLE ACSTTYHYLC NEEFTIFNRV DIARSQLLDE LVDKFNRLLE
DFLQEGEEPD EDDAYQVLST LKKITAFHNA HDLSKWDLFT SNYSLLSTGL QNGDMPEQIV
IHAMQCTHYI VLWHLAKVSE GSSIKGDLVT LRKQMRTFCL ICQRYLSSIN TAVKEQAFTI
LCDVLLIFSH QIMSSGREHL ENLVYVPDSS LQAELLTFIL YQVFIDQDDD SNSTDGQQDD
EASKIEALHK RRNLLAAYCK LIIYNVVEMN TGADIFKQYM RYYNDYGDII KETMSKTRQI
DKIQCAKTLI LSLQKLFNEM MSELGFNFDR SLSAFCGIKE LARRFSLTFG LDQLKTREAI
AMLHKDGIEF AFKEPSPQGE GGPPLNLPFL DILSEFSISG QIHMYLERFM TFQMALQRDD
CWLPLISYRN SLQAGMDDDT MSVISGISSR GSVRSKKSKQ SAVSKRKLPE GMLIYRLLAE
ENSSSSFDGV WMNREQSVPT PVMMHSPHLT STVLRDPKRM RPEDGYAATF SMPAEQHLHQ
ATQVTWMLTQ RQQAEARQHQ ERISMHYAKM RNHMQQAIRR GSGLMEDDEE PIVEDVMMSS
EDRLEDINEG MDFNTMEIDL PASKNRRERN ELKPDYFDPS SIMDDSVRII SVLCLYSSTF
ILNDPLNMLL LTH
//
