GenomeNet

Database: UniProt
Entry: M4ABV7_XIPMA
LinkDB: M4ABV7_XIPMA
Original site: M4ABV7_XIPMA 
ID   M4ABV7_XIPMA            Unreviewed;      2358 AA.
AC   M4ABV7;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   24-JAN-2024, entry version 55.
DE   RecName: Full=histone acetyltransferase {ECO:0000256|ARBA:ARBA00013184};
DE            EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000011951.2, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX   PubMed=23542700; DOI=10.1038/ng.2604;
RA   Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA   Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA   Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA   Postlethwait J.H., Warren W.C.;
RT   "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT   evolutionary adaptation and several complex traits.";
RL   Nat. Genet. 45:567-572(2013).
RN   [3] {ECO:0000313|Ensembl:ENSXMAP00000011951.2}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000011951.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   Ensembl; ENSXMAT00000011967.2; ENSXMAP00000011951.2; ENSXMAG00000011929.2.
DR   eggNOG; KOG1778; Eukaryota.
DR   GeneTree; ENSGT00940000155364; -.
DR   HOGENOM; CLU_022938_0_0_1; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000123; C:histone acetyltransferase complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:UniProt.
DR   GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003713; F:transcription coactivator activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR   CDD; cd05495; Bromo_cbp_like; 1.
DR   CDD; cd20910; NCBD_CREBBP-p300_like; 1.
DR   CDD; cd15647; PHD_CBP; 1.
DR   CDD; cd15802; RING_CBP-p300; 1.
DR   CDD; cd02337; ZZ_CBP; 1.
DR   Gene3D; 2.10.110.40; -; 1.
DR   Gene3D; 3.30.60.90; -; 1.
DR   Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR   Gene3D; 1.10.246.20; Coactivator CBP, KIX domain; 1.
DR   Gene3D; 1.10.1630.10; Nuclear receptor coactivator, CREB-bp-like, interlocking domain; 1.
DR   Gene3D; 1.20.1020.10; TAZ domain; 2.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR018359; Bromodomain_CS.
DR   InterPro; IPR031162; CBP_P300_HAT.
DR   InterPro; IPR013178; Histone_AcTrfase_Rtt109/CBP.
DR   InterPro; IPR003101; KIX_dom.
DR   InterPro; IPR036529; KIX_dom_sf.
DR   InterPro; IPR009110; Nuc_rcpt_coact.
DR   InterPro; IPR014744; Nuc_rcpt_coact_CREBbp.
DR   InterPro; IPR037073; Nuc_rcpt_coact_CREBbp_sf.
DR   InterPro; IPR010303; RING_CBP-p300.
DR   InterPro; IPR038547; RING_CBP-p300_sf.
DR   InterPro; IPR035898; TAZ_dom_sf.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR000197; Znf_TAZ.
DR   InterPro; IPR000433; Znf_ZZ.
DR   InterPro; IPR043145; Znf_ZZ_sf.
DR   PANTHER; PTHR13808; CBP/P300-RELATED; 1.
DR   PANTHER; PTHR13808:SF34; CREB-BINDING PROTEIN; 1.
DR   Pfam; PF00439; Bromodomain; 1.
DR   Pfam; PF09030; Creb_binding; 1.
DR   Pfam; PF08214; HAT_KAT11; 1.
DR   Pfam; PF02172; KIX; 1.
DR   Pfam; PF06001; RING_CBP-p300; 1.
DR   Pfam; PF02135; zf-TAZ; 2.
DR   Pfam; PF00569; ZZ; 1.
DR   PRINTS; PR00503; BROMODOMAIN.
DR   SMART; SM00297; BROMO; 1.
DR   SMART; SM01250; KAT11; 1.
DR   SMART; SM00551; ZnF_TAZ; 2.
DR   SMART; SM00291; ZnF_ZZ; 1.
DR   SUPFAM; SSF47370; Bromodomain; 1.
DR   SUPFAM; SSF47040; Kix domain of CBP (creb binding protein); 1.
DR   SUPFAM; SSF69125; Nuclear receptor coactivator interlocking domain; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   SUPFAM; SSF57933; TAZ domain; 2.
DR   PROSITE; PS00633; BROMODOMAIN_1; 1.
DR   PROSITE; PS50014; BROMODOMAIN_2; 1.
DR   PROSITE; PS51727; CBP_P300_HAT; 1.
DR   PROSITE; PS50952; KIX; 1.
DR   PROSITE; PS50134; ZF_TAZ; 2.
DR   PROSITE; PS01357; ZF_ZZ_1; 1.
DR   PROSITE; PS50135; ZF_ZZ_2; 1.
PE   4: Predicted;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW   Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW   ProRule:PRU00035}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW   ProRule:PRU00203}; Methylation {ECO:0000256|ARBA:ARBA00022481};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00203};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00228}.
FT   DOMAIN          359..445
FT                   /note="TAZ-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50134"
FT   DOMAIN          604..683
FT                   /note="KIX"
FT                   /evidence="ECO:0000259|PROSITE:PS50952"
FT   DOMAIN          986..1058
FT                   /note="Bromo"
FT                   /evidence="ECO:0000259|PROSITE:PS50014"
FT   DOMAIN          1206..1583
FT                   /note="CBP/p300-type HAT"
FT                   /evidence="ECO:0000259|PROSITE:PS51727"
FT   DOMAIN          1585..1633
FT                   /note="ZZ-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50135"
FT   DOMAIN          1647..1728
FT                   /note="TAZ-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50134"
FT   ZN_FING         359..445
FT                   /note="TAZ-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00203"
FT   ZN_FING         1647..1728
FT                   /note="TAZ-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00203"
FT   REGION          1..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          96..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          180..220
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          281..360
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          453..475
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          511..537
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          697..722
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          833..874
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          889..966
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1439..1497
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1756..1850
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1903..1937
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1950..1981
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2021..2048
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2106..2136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2191..2341
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..124
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        133..166
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        180..201
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        288..308
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        322..342
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        697..712
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        844..863
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        889..950
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1439..1454
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1471..1485
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1770..1785
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1827..1850
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1950..1965
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2024..2048
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2191..2233
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2248..2264
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2273..2287
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2314..2336
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2358 AA;  256594 MW;  A81F90AE6C9F3F73 CRC64;
     MAENLLDVGP PSSKRPKLNS PALSASDGQD LGSLPWDDLE NDLPDELIPN GGELSQLSGL
     PSNGGATPGG GPGGTAGALG GGAAIVPDAA SKHKQLSELL RAGSTSSITG TGLNSASPQP
     GSMAPQLGTP LGKSPLGQGS PNSHSSPQGQ KPGTPTGVVG QNSNNNAAAM GLSATGFSQA
     MINNSPGHSG LLGQGGQPQP GQVMNGGLVP SGGRGRGAGV AGLQYQGQTI PGSTAGPGAS
     GSALVETLTQ GGQQMGAHAA QQAGNMNKMS LGSNGSLFGA QPYGQGAAGP GQQLNPQQQL
     QNKAALASSL PPFPNELKGA AVTSGPNMQL QQPPQQQAGM LPLANSGGVA VSSAGPTADP
     EKRKLIQQQL VLLLHAHKCQ RREQANGEVR QCALPHCRTM KNVLNHMTHC QAGKSCQVAH
     CASSRQIISH WKNCTRHDCP VCLPLKNASD KRTQQPLLSS PNTGLQNPMS TVGMGQPSAP
     TINTSAPIDP SSMQRAYAAL GLPYSSQAAG QAAAQQAPGQ AAGAQNSQAQ QQQQLPQQMR
     PINTIGNQMA LGGGAMGVAT SEQTNLHTDS LSNTLNTNNQ LLSDGSAVGQ MGSLPTAAPV
     SSASARKAWH EHVTQDLRNH LVHKLVQAIF PTPDPAALKD RRMENLVAYA RKVEGDMYES
     ANSRDEYYHF LAEKIYKIQK ELEEKRRSRL QKQIISQAPI AGQGTQQPGL PQPNALGPRP
     QNGPVSLPNM PNQIMNRIQV PQGMNQFNHM TLSNAQTSMG PRAASPMTHP QQMNISSVPA
     VGMSPSRMPQ AQGIMPGHSN MVGQTPSQGQ FLPQTHFTPG SGAVSVSSAM NVTVGPGMGQ
     PPAQAPVTQL SQPGASLDNR VPTPASAASA DLHSQHVGAD LPAQDLKAET RTDQQEFEAA
     GGKIEPKTEA ENDSASASVK KEEPEEKPEP MEVEEKKPEM KTEPKEEEEN GTNGTTSSSP
     SQSRRKIFKP EELRQALMPT LESLYRQDPE SLPFRQPVDP MLLGIPDYFD IVKNPIDLST
     IKRKLDTGQY QEPWQYVDDV WLMFNNAWLY NRKTSRVYKY CSKLAEVFES EIDPVMQGLG
     YCCGRKYEFS PQTLCCYGKQ LCTIPTGGTY YSYQNRYHFC EKCFNEIQGD SVTLGDDPAQ
     PQTMISKDQF ERRKNDVLDP EPFVECKDCG RKMHQICVLH YEVIWPSGFI CDNCLKKSAK
     SRKENKFTAK RLQSTRLGMY IEDRVNKYLK RQNHPEAGEV FVRVVASSDK TVEVKPGMKA
     RFVDTGEMPD TFPYRTKALF AFEEIDGVDV CFFGMHVQEY GSECPFPNTR RVYISYLDSI
     HFFRPRVLRT AVYHEILIGY LEYVKKLGYT QGHIWACPPS EGDDYIFHCH PPEQKIPKPK
     RLQEWYRKML DKAFAERILH DYKDIFKQAT EDRLTSANEL PYFEGDFWPN VLEESIKELE
     QEEEERKKEE TTAATETPEG TPSDSKNAKK KNNKKTNKNK SSVSRANKKK PGMPNVANDL
     SQKLYATMEK HKEVFFVIHL HSGPLANTLP PIVDPDPMIS CDLMDGRDAF LTLARDKHWE
     FSSLRRCKWS TMCMLVELHN QGQDRFVYTC NECKHHVETR WHCTVCEDFD LCISCYNTKG
     HEHQMVKWGL GLDDDNSQSG EASKSPQESR RLSIQRCIQS LVHACQCRNA NCSLPSCQKM
     KRVVQHTKGC KRKTNGGCPV CKQLIALCCY HAKHCQENKC PVPFCLNIKH KLRQQQLQHR
     LQQAQLMRRR MATMQGRTMP LPSPPAAAAP STPTSHAQPS TPQTPQQPLS NQPPTPNSAG
     VTSPTFPGVP RAGPPQASVS QGKPGPHASP LHQQQSPLPQ PPQQRQQQAP LAAIKMAHHI
     EMMAQAQQNQ QNYRVNMNGL PMTPQQTQQQ RMAQTMQMVA GPRGPQVMQQ PSLGQWPAAA
     GPMPAQNQQP GVVPNQNTPQ QAMSIQRAMM APGQQGQQRM LMPQQPGPRP QTPQRTGTIP
     PNALQDLLRT LKSPSSPQQQ QQVLNILKSN PQLMAAFIKQ RTAKYHASQP QPQAGQPQQP
     QQQQPGMPAM QTIAMQGGPV QRAAMPPQQP QQAPVQGMAQ LGSGQLMNAA HNANPQIQEL
     YRRQLLRQQQ QQQQPQQQGV MPQGHLGQFP NQPQGTSVMY SHIRMQQQQQ QQIAMQQAGA
     AGAGGVTMGQ LPPMAQMAQP GMSMDSAQNL LHQRMQQQQQ QAQLPQQQQA VLKQQMGSPA
     HPSPMSPQTH LLAGQAQGAA HLSAQPGLAN ALGNQVRSPA PVQSPAQQQQ PPPHSSPSRQ
     VQNQPQPSPQ HPALPHSGSP HPVLGGPLQS LEQGHLGTPE QSAMLPQLNT PNRGALSSDL
     GLVGDATGDT LERFVEGL
//
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