ID M4ACG2_XIPMA Unreviewed; 4569 AA.
AC M4ACG2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=FAT atypical cadherin 3 {ECO:0000313|Ensembl:ENSXMAP00000012156.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000012156.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000012156.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000012156.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSXMAT00000012172.2; ENSXMAP00000012156.2; ENSXMAG00000012113.2.
DR eggNOG; KOG1219; Eukaryota.
DR GeneTree; ENSGT00940000154981; -.
DR HOGENOM; CLU_000042_2_0_1; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 34.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 33.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24025:SF23; CADHERIN-4; 1.
DR PANTHER; PTHR24025; DESMOGLEIN FAMILY MEMBER; 1.
DR Pfam; PF00028; Cadherin; 26.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 32.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 34.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00232; CADHERIN_1; 13.
DR PROSITE; PS50268; CADHERIN_2; 32.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..4569
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017328356"
FT TRANSMEM 4179..4199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 45..160
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 161..268
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 377..472
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 473..578
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 597..725
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 727..831
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 832..936
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 937..1043
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1044..1153
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1149..1257
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1258..1364
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1366..1463
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1464..1569
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1570..1674
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1675..1772
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1773..1886
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1887..1985
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1986..2087
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2088..2189
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2190..2290
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2291..2397
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2398..2499
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2500..2603
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2604..2711
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2712..2822
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2823..2936
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2937..3041
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3042..3143
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3144..3248
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3249..3353
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3354..3458
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3459..3563
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3808..3846
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3848..4038
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 4041..4078
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4080..4116
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4118..4158
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 4325..4347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4385..4404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4385..4399
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 4068..4077
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4106..4115
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4148..4157
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4569 AA; 503611 MW; CC1AB9FE9645E0DF CRC64;
MGKWAGMQVP LLSLTLQLLL LISKPSAGYN QNSHETQDVP SFSFTHSVYH ATVYENSAAR
TYANSKIKMG IHLTKRSWEI RYRITSGDDE GLFKAEDYVL GDFSFLRIRT KGGNAAILNR
EIQDNYVLTV KAYVKGESLL EAWTKVSIQV LDMNDLRPLF SPTTYSVTIA ESTPLRTSIA
QVTATDADIG SNGEFYFFFK DKMELFAVHP TSGVVYLSGK LNVDEQDRYD LEIMAVDRGM
KLYGNNGVSS TAKLFVHIER VNEHAPVMTV VTHASSRLEK NSLYALVSVE DFDEGLNGEI
DSVTIMDGDP SGQFYIERGE EEEFAIKSTE MINWETFPYG CNLTLQAKDR GSPPQFSDPQ
VLHIMFSNQQ TTEANFEQEF YVVSLNEVSP PGTIVGFFKI KPEPDDAEYI LTPSADSTFF
KINTLTGVIS TSRWLTHVSK DIFSLEVLEV DSNLRAKVQV AIEDANDNTP EFSQSFYEVF
VNESVPAGTN VLTVSAVDDD KGENGYITYS IHCLQQLPFK INQFSGVISS NTDLDFEASP
EVFVFVVRAS DWGSPYRRES EVNVTIHLQN VNDNKPLFEK VACKGVISVD FPVDEAITTM
SAIDIDELEL VKYKIISGNE LGLFDLNPDS GVLALRNSLS ALGPKYSIFS LKITSTDGEN
FSDPMFVNIS VVHGKSLYKH FTCKETSVAQ RLAEKLLTKS KASTKSKTEE GFIDLFSVNR
QTPQFDKAFP TDIAVQEDLK VGSSVFQVNA YDGDTGFNGQ ILYSISDGNT DSCFNIGLQT
GLISVFLPMD REKRDHYILN LTIFDLGLPQ KATWRLLTVH IVDANDNAPQ FLQEGYRIVI
PENTAIGTII IQVEATDKDL GLNGEIVYSL LTSTTQFDIN STNGIVYVTG QLDRELVPTY
NLKIKARDSA AKGRHKFSVT ILKVILEDVN DCPPLFIPSV YKARALEDLP VGTVIAWIDT
QDPDVGLGGQ VRYSLVNDHN GWFELDRNSG AIRLTKELDY EVQQFYNLTV KAKDKGKPVS
LLSVTFVELE VIDVNENLYA PYFSHFALTG RIEENAPIGT TLLQVSAQDD DVGRDGEIHY
SIRDGSGLGR FAIDEETGVI YTTDTLDRET KDSYWLTVYA SDRGVVPQFS TTEVFIEVDD
VNDNAPLTSE PLFRCSVPEN SPRDVSVIQI HAQDPDVSPP STADWLSYRI VSGNPQNFFT
INSRTGLITT TSRKLDREQQ QEHALEVLIS DSSTSPKSST LWVMVSVLDE NDNRPTFHDK
VYQVRLPERE RRKKAEPIYR VFAYDQDDGP NSDLSYSLVD GNEDGKFFID PKTAVVSSRK
AFAAGSYDIL TIKASDNGRP QKSSTARLHI EWIRRPPPSS PPLLFDEPFY NFTVTENDKV
AEIVGVVSLQ QNPVPVWFDI TGGNSDSVFD VERTAATIII AKPLDAEQRS FYNLTVLATD
GTSTAYVQVY ITVLDSNDND PVFSQGVYEV IISEDTPPNT EVVQMLASDR DEHHQLTYSL
HSSIDSRSMR LFHIHPTLGT VYTAQRLDHE ACAQHILTVI VKDQEFPYRK NLARVLIEVE
DTNDHAPFFT SALYEGLVYE SAAVGSAVVQ VTALDKDKGK NAELHYSIEA GNTGNAFNIE
PVLGILRVAR HLDLSSIGHY VLSVRVTDNG TPPLSATTIV RITITLSDNS GPRFLQPEYQ
TEIRENAIIG TSVTTISAVS QSTLTFDIKQ GNIEQVFQIN QYSGVITTQK PLDYENIASY
SLVVQATNMA GMASNASLLI QILDENDNPP VFQQHHYHGS ICELAPVNSV VLNSENLPLV
IKASDADSNQ NALLVYQIVE ETAKMFFTVD SVTGSIRTIA NLDHETFSAF HFHVNVRDNG
KPQLIADSPT EVTIQVMDSN DSPPLFKQNT YETVLLLPTY IGVEVLQVSA IDPDTDIPTD
LTYSLAEGVL ENFSIKSSSG IIVVKNSNFS KELFRVSVRV SDGKFSTTAL VTIIVKEALD
SGLSFSQKVY VSSIKENVSN ISVVAVVSAV GNRLNEPLLH TLLNAATMFT IRPTSGVIQT
TGIPFDREEQ DFYELIVEAR REHDHQHVAR VLVKVHIEDI NDNAPVFVGL PYYAAVQVEA
ESGLSIFKVS AVDGDKGING EVTYFLKDDH GHFMIDQQTG TISLKRTFES DLSNAEYQME
IHAKDCGDPP LSSTITFPIT VVNKAMPVFD KSFYSVSVNE DVDVHTPILG INATSPDGQN
IIYTIVVGDA SFQFGIGFDT GVISVINSLD YEETPYYRLT IRATNYLTGS HAEVDVDVLV
QDINDNPPIF KEMSYRIVLS ETVMIGTPAL QVIATDMDSE KNNVVGYQIF SKEHNSTDYF
HIDSSSGLIL TARILDHELV PEYDFIVRAT DNGFPSLSTE VSVTVLLKDM NDNPPVFNQL
LYEAYVSELA PKGHFITCVQ ASDADSSDFD KLVYSILSGN ERMDFVMERK TGIIMLSSHL
KQRMEPTYNL NVSVSDGVFT STAQVHVKVF GANLHDPVFE QKMFEAELRE NSPVGTNVIQ
VRATDADPGL YGHITYSFVN DVGNDLFSID ANGQISTIEK LDREDPSNMD IVLTVAAQDS
GGRVSYCTIH LTILDENDNA PRFSATEYRA TLKFDVAKGF FITQIQALDP DYGSNAKVTF
SLYSEARIPV ADILDIDTDS GWLVTKGSFS HLRNSVLSFF VKAVDGGYPV RHSLVPVYIH
VLSPEAFFPD FMQHHYSFSI LENTPVGSVI GRVHLKSPHG YNPHSVSFDI VNGESSENNL
DGVFLVEKNT GVIKLDKPLD HEVMKGFSFK ITATGHQSKL DAVTSVDVEV KVLDLNDNKP
AFESNSYVTT VMEGMTIGTR VIQVKAHDPD SGANGQVTYR LGTLIQAEEN SDALVRTFSI
DSNTGWIVLC KELDHESNPS YIFTVVASDL GETLSFSSTS TVTVAVTDIN DNPPIFMENH
YFSTVQESGP PGEVVAVLNT KDNDSSAVNR HVSYVITGGN YRGVFALGLV QGEWKMYVKG
PLDREERNLY IINVTASDGL FVSHTIVEVT VMDTNDNNPI CDQVVYTANI PEDLPLSSVL
LRVGATDADA GSNARLKYSL HGPGSQDFIM DPDTGEIKSS VALDRETNPN YRLTAKATDG
GGRWCRAEVQ LVVTDVNDNP PLFTLSQYYV SVYEDTPVKA LLTRIHAVDP DEGPGRMVVY
SLADSAGGFF SIDEFTGIVV LEHILDREVQ PTHQITVRAS DQGTPRPLFS LVNITITVLD
INDNPPVFER RDLLATVPED VGVGTEVLRV HAASKDIGTN AEISYSIRSG NEHRRFYIHP
LTGAILVALP LDYDTCKDYF LTVEARDGGT PPLSAITTLN INLTDVNDNA PVFSYALYTA
VVPEDSTIGH FVVQLVAEDA DSGLNGAVFY SIFSGDQDNE FFIDPTSGII KVNKPLDRET
VPSYSLAVRA LDTGTPPMSS TAVVSIEISD INDNPPTFFP ANLTAVIQEN KPIGTRILQL
SVIDQDASHN GPPFSFSILS GNNGKEFELE TDGTLVANQV LRRDIAKDYV LQIQVSDSGK
PTLSSSSNLT VRVIEESLHR PVAFPLEIHI ITMEDEFPGG VIGQLHATDA DPYDALTFGH
AAPSQRSLFK ISPHDGKIIA LSGLDAGEYF LNASVSDGRF NVPVPVRVHV EQATLEMLRD
AVTVRFESVA PQEFVASYLK SLLKVMQQAA TSQQHDTLHL LSLQPVGGTQ QLDLLVSVAT
AGGGYYKAAY LTQKLSTSRR KLEDVLRVSA ILDKNCSGLE CRGAQCEQSI TLDSHNLATY
STPRASFVSP RFHRTSRCTC HDASCAVLLE QCEEQLCPPD MQCVSVEATR GRYACQCPRG
KLGECAGHSS LSFSGNSYIK YRLSNQLQTE LKLTLRIRTL QSRGIIMYMH NERCIILKLE
EGKLWFQLSC DPLPSRGADG PDMLGPAGRR INDGNWHTVA LELNRNFSSL ALDDSYIEQR
HPPSLIQTLP PDRTFYFGAL VQPPNSRNLV VSQKEPRVFE GFQGCLDSVM LNNKELPLQN
KRSQYAEVVE LTELKLGCIL YPDACHHQPC RNGATCTSLP SGGFTCSCNP QYTGGNCEME
VTVCVPNPCQ NSGVCKPIGN AFLCSCRRGF RGLMCEEDVN ECDRNNPEGE CENGGTCINT
PGSFYCNCTP GFVGQRCTLR PVVVPDMQAG HAVVGKEELI GITGVLFVII VLIVLFIAFR
KKVFNKNYSR NNLSLVQDPA TAALLNKANC IQPTLMGGVG IIGPPQVPVR PMAYTPCFQG
DPLSKLEKLS EKHTLDHTEM STFHPESPRI LPGTIRRGVV VCSVAPNLPP VSPCRSECDS
IRKSPLASDD GELATEGDTC FSGSNSEAQS LSSFQSDSCE DNAYHWDTSD WMPSTRLPDT
EEVQTFRSPS DSDTVGLDSS LGGPTHELES DYYLGGYDVD SDYPLPHEEE FLSHEQLPPL
LPGSEDCPEP CTPLLSNVPV SKETVQNTSS IRHPDCRPHF HPSQYLPSHQ LPTGNVHHRH
TTTPVDQASP VNGDAAASLN MHPSVGTESM CHLSTTCVLD SEHGSHCDGL SEVRRGVTII
TDSQQQTEV
//
