ID M4ACP1_XIPMA Unreviewed; 524 AA.
AC M4ACP1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Growth differentiation factor 5 {ECO:0000313|Ensembl:ENSXMAP00000012235.2};
GN Name=GDF5 {ECO:0000313|Ensembl:ENSXMAP00000012235.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000012235.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000012235.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000012235.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR AlphaFoldDB; M4ACP1; -.
DR STRING; 8083.ENSXMAP00000012235; -.
DR Ensembl; ENSXMAT00000012251.2; ENSXMAP00000012235.2; ENSXMAG00000012227.2.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00940000160455; -.
DR HOGENOM; CLU_020515_0_0_1; -.
DR InParanoid; M4ACP1; -.
DR OMA; AECAPES; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0035141; P:medial fin morphogenesis; IEA:Ensembl.
DR GO; GO:0035138; P:pectoral fin morphogenesis; IEA:Ensembl.
DR GO; GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
DR CDD; cd19399; TGF_beta_GDF5; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF44; GROWTH_DIFFERENTIATION FACTOR 5; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..524
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017481095"
FT DOMAIN 390..524
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 25..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 524 AA; 57583 MW; 2D8178D74CEA2B43 CRC64;
MNVVTRLSLL LSCWTLFYLH PVRGSLSRSG PAERTGGTHR GSAHPSGRQP VPAAGSWKPH
AGPPLITAET IPLRGKQTAG GNPEHPHPHH HQQLEQPTGA LDLGRKEAAR SWPPAADARL
KPHAPAHAGG GVGVGDSPGK PGGKVAARAS AAAAAARGGF PPAAQRGAAA RRQKLGDKQP
LVTPHDYMLS LYWSLSSGNL NSSALHEAGL ANTITSFVDR GHDDRGPMLR RQKYQFNISS
LERDGLLGAE LRILRKLVSV AAADGGSVPW LKLYSCASGR QKAALLQSRT VDDLLGGFSN
KWEVFDIYKV FKGFKSQQLC LELEALEHRG GRPLDLRTLG FARPGRTNKE KAFLLAFGKS
KKRDLFYNEI KARSGHDNKT VYEYLFNQRR MRRAPPPRGA KKPLRVPSQI LLQHQAAKSR
PRCHRRRLHV NFKDMGWDDW IIAPLEYDAY HCDGACDFPI RSHLEPTNHA IIQTLINSMD
PDTTPPTCCV PTRLSSISIL YIDSANNVVY KQYEEMVVES CGCR
//
