ID M4ACV8_XIPMA Unreviewed; 896 AA.
AC M4ACV8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=CCR4-NOT transcription complex subunit 3 {ECO:0000313|Ensembl:ENSXMAP00000012302.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000012302.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000012302.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000012302.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CNOT2/3/5 family.
CC {ECO:0000256|ARBA:ARBA00007682}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_014324177.1; XM_014468691.1.
DR AlphaFoldDB; M4ACV8; -.
DR STRING; 8083.ENSXMAP00000012302; -.
DR Ensembl; ENSXMAT00000012318.2; ENSXMAP00000012302.1; ENSXMAG00000012273.2.
DR GeneID; 102227415; -.
DR KEGG; xma:102227415; -.
DR CTD; 449540; -.
DR eggNOG; KOG2150; Eukaryota.
DR GeneTree; ENSGT00390000014743; -.
DR HOGENOM; CLU_013819_1_0_1; -.
DR InParanoid; M4ACV8; -.
DR OMA; YKPQTPY; -.
DR OrthoDB; 10289at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0030015; C:CCR4-NOT core complex; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0048565; P:digestive tract development; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:2000036; P:regulation of stem cell population maintenance; IEA:UniProt.
DR Gene3D; 2.30.30.1020; CCR4-NOT complex subunit 2/3/5, C-terminal domain; 1.
DR InterPro; IPR038635; CCR4-NOT_su2/3/5_C_sf.
DR InterPro; IPR012270; CCR4-NOT_su3/5.
DR InterPro; IPR040168; Not2/3/5.
DR InterPro; IPR007282; NOT2/3/5_C.
DR InterPro; IPR007207; Not_N.
DR PANTHER; PTHR23326; CCR4 NOT-RELATED; 1.
DR PANTHER; PTHR23326:SF1; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3; 1.
DR Pfam; PF04153; NOT2_3_5_C; 1.
DR Pfam; PF04065; Not3; 1.
DR PIRSF; PIRSF005290; NOT_su_3_5; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 4..232
FT /note="CCR4-Not complex component Not N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04065"
FT DOMAIN 765..890
FT /note="NOT2/NOT3/NOT5 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04153"
FT REGION 236..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 612..671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 896 AA; 96335 MW; ADEA1306CF34B1EA CRC64;
MADKRKLQGE IDRCLKKVAE GVEQFEDIWQ KLHNAANANQ KEKYEADLKK EIKKLQRLRD
QIKTWVASNE IKDKRQLVEN RKLIETQMER FKVVERETKT KAYSKEGLGL AQKVDPAQRE
KEETGQWLTN TIDTLNMQVD QFESEVESLS VQTRKKKGDK EKQDRIDELK RLIERHRYHI
RMLETILRML DNDSVPVDAI QKIKDDVEYY IDSCQDPDFE ENEFLYDDLD LEDIPPALVA
TSPSGNVEDD MYLHSSSTPT STTSSSPIPP SPATCTAENS EDDKKRGRST DSQVSQSPVK
NGAPSLQSSF SSSATSGSSS SSSLSMASVV GGIPAIPTSS LIGSFSSAVQ QHQHQSAQQQ
QQSQPSNPSQ QQPPQTKPSV PSNNNNPSPP SNPLLPASTA PSLSTPSTPS LTAPNSQSSP
GPTPASSLGL GLGLDLRKGG MSGTSSANQM PSLGLAGHST PLNTMASLIQ GSTSALYAHA
AASGSLGLSS TTQSSILPES STSISNSSSS GVTTNGAGSG LSLLGSSPAH NSLTGSILGL
VPGQSVAPAT SQVPSSPASS APGSVGMMVG NGGNAGVVGV NAAPARPPSG LKQNGSPSYS
AVVAESSTES ALSTLSQSQS SQTSSLSSST SQPMDNGPSL ISSITLPPSS PSPSFSDSTP
GGGSLLNGPH SYPQASEGLK APEPLSSLKA MAERAALGSG LDGEISNMHV NDIFSGSSAA
PGTPAAPQQS VSEVSIPPSL GVCPLGPTPL SKDQLYQQAM QEAAWTHMPH PSDSERIRQY
LMRNPCPTLP YHHQVPPHHS DTIEFYQRLS TETLFFIFYY LEGTKAQYLS AKALKKQSWR
FHTKYMMWFQ RHEEPKTITD EFEQGTYIYF DYEKWGQRKK EGFTFEYRYL EDRDLQ
//
