ID   M4ACY6_XIPMA            Unreviewed;       913 AA.
AC   M4ACY6;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   27-MAR-2024, entry version 45.
DE   SubName: Full=Sorting nexin-19-like {ECO:0000313|Ensembl:ENSXMAP00000012330.2};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000012330.2, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX   PubMed=23542700; DOI=10.1038/ng.2604;
RA   Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA   Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA   Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA   Postlethwait J.H., Warren W.C.;
RT   "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT   evolutionary adaptation and several complex traits.";
RL   Nat. Genet. 45:567-572(2013).
RN   [3] {ECO:0000313|Ensembl:ENSXMAP00000012330.2}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000012330.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC       {ECO:0000256|ARBA:ARBA00010883}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_005802995.1; XM_005802938.1.
DR   AlphaFoldDB; M4ACY6; -.
DR   Ensembl; ENSXMAT00000012346.2; ENSXMAP00000012330.2; ENSXMAG00000012306.2.
DR   GeneID; 102238130; -.
DR   KEGG; xma:102238130; -.
DR   CTD; 100170806; -.
DR   eggNOG; ENOG502RT3A; Eukaryota.
DR   GeneTree; ENSGT00950000182856; -.
DR   HOGENOM; CLU_012033_0_0_1; -.
DR   OrthoDB; 2919310at2759; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   InterPro; IPR003114; Phox_assoc.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR013937; Sorting_nexin_C.
DR   PANTHER; PTHR22775:SF33; SNX19A PROTEIN; 1.
DR   PANTHER; PTHR22775; SORTING NEXIN; 1.
DR   Pfam; PF08628; Nexin_C; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02194; PXA; 1.
DR   SMART; SM00312; PX; 1.
DR   SMART; SM00313; PXA; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS51207; PXA; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   DOMAIN          90..266
FT                   /note="PXA"
FT                   /evidence="ECO:0000259|PROSITE:PS51207"
FT   DOMAIN          474..604
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
FT   REGION          304..349
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   913 AA;  102550 MW;  190435A92ECBB3DB CRC64;
     MPSSKSSTHW TLLELFGQRR LLGFGAILAW LILFHLLVNV WLLCIFTSLL VVLGGWLGSR
     AALDANSFLH LEHFLPLGKV NPPLCSPEHE WRLDHEIHCA VHKAVRDFVS SWYRTLLPEV
     EGEFERAVRH SMLESVMELK ERARRVDRKA LVQRLLELYG CHLQSYMTVR QIQSAQKESS
     GQWQLYSKVE SPHPAVSSST AELNYTRALV KLVLHVLVPY PQMETRTGGY MVTELITCNV
     LLPLISRVSD PDWLNQTIVD IFTKTRESQD ISVDDPSVGA LYKGHGREES WTTCKSLSIS
     DQTDFSSKNT SVDLDEPQSQ SANSGTDLSQ SRLVSLTSTS RTSSYQPGLN TPSKVNCCSL
     TSGQYKQSSE TKTVSADPLL HSDSDDDLTA SACDCAPTTN LCNLLPVNDE EACGCFQPLR
     NFGSKVVEPK DSQWPAGIAQ DKSPVCPPKK LCLTSYSFDL SRGPTTTPFR VQNVHISGTV
     NVKEQRSAGT HPYTLYTLKF ETVADGDCTG AAPPAVCHTV NRRYSEFLNL QARLEEKPEL
     KKLIRNVKGP KKIFPDLPFG SQDGEKVEAR KSQLDTFLKQ LNSTPETANS EDMQEFLAIN
     SDVCTYFGRK PLTKSRIDKM MENALDTLRT AFPHPELFSP TEDIEGDTDG RTMDYRKYRR
     LFPSKVSQSL NIPDLHPKVT YCFSEGSSVL NGMSLCGLEN FVREQERLIG GPNMTETVKP
     SYELKAKDKK ISGKTHGTDT AVADVALNIL CLLMKDHWSW LCTENIQKAI RLLFGTFIER
     WLDIGAAHLT SAPCWVIYLQ VLQEAVWPGG TLPAQPRPER SVAEKKETKE QCLNCLMQLL
     PELIADMLGS EKYRLSLETM LESLQDYQIN KHLIYSICDL LLEFLIPESS DVTFQRSLLQ
     SLTKDTERNS LHM
//