ID M4AD46_XIPMA Unreviewed; 1444 AA.
AC M4AD46;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Collagen type IV alpha 2 chain {ECO:0000313|Ensembl:ENSXMAP00000012390.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000012390.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000012390.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000012390.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Type IV collagen is the major structural component of
CC glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork
CC together with laminins, proteoglycans and entactin/nidogen.
CC {ECO:0000256|ARBA:ARBA00003696}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
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DR Ensembl; ENSXMAT00000012406.2; ENSXMAP00000012390.2; ENSXMAG00000012179.2.
DR eggNOG; KOG3544; Eukaryota.
DR GeneTree; ENSGT00940000168406; -.
DR HOGENOM; CLU_002023_1_0_1; -.
DR OMA; FDPNQDK; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR Gene3D; 2.170.240.10; Collagen IV, non-collagenous; 1.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR001442; Collagen_IV_NC.
DR InterPro; IPR036954; Collagen_IV_NC_sf.
DR InterPro; IPR016187; CTDL_fold.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24023:SF588; COLLAGEN ALPHA-2(IV) CHAIN; 1.
DR Pfam; PF01413; C4; 2.
DR Pfam; PF01391; Collagen; 12.
DR SMART; SM00111; C4; 2.
DR SUPFAM; SSF56436; C-type lectin-like; 2.
DR PROSITE; PS51403; NC1_IV; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}.
FT DOMAIN 1222..1444
FT /note="Collagen IV NC1"
FT /evidence="ECO:0000259|PROSITE:PS51403"
FT REGION 1..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 798..828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 889..909
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 945..1183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1444 AA; 143198 MW; EFFC30BA1FDC39C5 CRC64;
MTKVLKGVKG ETGDIGPQGL PGNYTTQQRQ PITGPSGFPG DKGERGDLAD NLDGKGETGI
MGMPGPRGES GANGPPGRKG EPGYPGLNGR EGPKGGTGDP GELISSGFPW SAGGLPGPRG
ETGPDGERGR IGDQGSPGPP GRPASDTQQQ IWDFFGPFGA KGEQGDKGLP GDQGRSAVLP
GPKGSDGSPG SRGPPGPRGS WKEFFKGDEG PRGRPGNAGV KGFKGNHGEC QCSGENFRPG
LPGPAGERGD PGMTGEFGYE GDMGDQGPRG ADGFPGFAGL SGFPGPKGRK GETSFAREKG
YPGEPGDPGI DGVVGLHGSP GPNGLHGLSG NRGPPGEGPW GERGDKGFPG WPGRPGSAGL
VGTPGENFVG IKGQHGPPGD DGLAGYDGVQ GTPGSPGDCI PHGAGGQVDV TGVCEPIPGP
PGQPGPPGLS GIAGFPGAPG PRGFSGPQGV NGEKGEQGEL GRGGTPGPRG FPGPRGDLGT
PGSKGSLGNP GVPGMPGRYG SQGEKGPHGE VMGASPGPPG DPGLPGLRGQ KGHLGDQGQP
GFSGINGMPG MIGFRGLKGA PGLPGEEGRP GPAGKYGFPG DPGRSGPPGP AGTTGEPGRT
GERGTEGDSG PPGPIGLKGM PGAYGDDGVI GARGLPGDPG QPGATGRPGL PGLKGKKGSH
GTSGFEGVTG HSGLKGFEGQ RGGPGTPGEV GLKGLSGSKG ERGEQGLQGK PGVMSPKMLL
HIKGTKGEHG HQGTPGFTGP RGTKGDQGVP GYDGTHGLPG DPSNEKGVDG DPGAQGLPGI
KGMPGTPGNR GIQGFDGMHG DKGGKGSPGA YGHSGVQGKK GGKGDKGIRV DLPGSPGLRG
EDGFTGEPGL KGLLGPIGDL GITGFDGIEG VKGVAGNLGI EGYPGLDGQR GTPGNQGQKG
FPGIPGEDGL PGVPGFSGSK GYPGLQGLYG LDGLKGQKGV SGTPGLDIIG PAGETGVKGR
KGESGIPNSQ PGSPGPSGLK GFQGNLGDFG QPGLPGLRGL QGPVGIPGLP GKTGDPGFPG
PQGSQGYPGT SGPPGLDAFP GEKGVPGENG FPGPTGTRGS RGDSGPAGYR GPDGISGKKG
PKGDQGHMGI PGQTGLQGER GPVGPKGDTG LPGLPGVPGS QGRPPPSITI PGERGHPGLR
GIQGPKGTSG GPGPRGPPGE PGFMGPVGLK GMPGISGTPG VPGYRGEVGN VGHPGLQGME
GQRGRPGGPG LPGMAGRSIS VGYLLVKHSQ SEQTPMCPVG MSKLWDGYSL LYLEGQEKAH
NQDLGLAGSC LPRFSTMPFL YCNPGDICYY ASRNDKSYWL STTAPLPMMP VEEKEIQPYI
SRCSVCEAPS VAIAVHSQDI TIPQCPVGWR SLWIGYSFLM HTAAGNEGGG QSLSSPGSCL
EDFRTTPFIE CNGAKGTCHY FANKHSFWLT SIDQSFHTQP SSETLKAGQL LSRISRCQVC
MKNL
//
