ID M4ADF0_XIPMA Unreviewed; 1344 AA.
AC M4ADF0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Ras-associated and pleckstrin homology domains-containing protein 1-like {ECO:0000313|Ensembl:ENSXMAP00000012494.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000012494.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000012494.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000012494.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 8083.ENSXMAP00000012494; -.
DR Ensembl; ENSXMAT00000012510.2; ENSXMAP00000012494.2; ENSXMAG00000012467.2.
DR eggNOG; KOG3751; Eukaryota.
DR GeneTree; ENSGT00940000156552; -.
DR HOGENOM; CLU_267159_0_0_1; -.
DR InParanoid; M4ADF0; -.
DR OMA; FPIPAQF; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01259; PH_APBB1IP; 1.
DR CDD; cd16136; RA_MRL_Lpd; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR039664; GRB/APBB1IP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039665; PH_APBB1IP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR11243; GROWTH FACTOR RECEPTOR-BOUND PROTEIN; 1.
DR PANTHER; PTHR11243:SF15; RAS-ASSOCIATED AND PLECKSTRIN HOMOLOGY DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50200; RA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 324..410
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 451..560
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 590..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 637..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 753..957
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 970..1344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..21
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..665
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..699
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..773
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 788..821
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..904
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 912..939
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..957
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1011..1047
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1073..1119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1161..1208
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1210..1235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1236..1250
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1251..1269
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1304..1318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1344 AA; 144088 MW; 40C06046061BABE3 CRC64;
MDQVSDDELD HGAEEDSDKE DQDLDKMFGA WLGELDKLTQ SLDDGRPQKA LQKPPLRQET
NIANFSYRFS MYNINEALNQ GDTVDLDALM ADLCSIEQEL STISKPNSAS RSQNKGQQRG
PGGRSASTKH PGTSGGGNSG GSSVSLHTVR GGSASSRSAA SNISLDDITS QLEKASLSMD
EAARQTSSSS STSSSSSSVS STALRRPSSG SSGGRQHRRT GSVGTACEQE AQSQRSSINS
ACASASSMDS LDVDKGMTGG EADEQVGSQQ PCYPHSYLDR ETSLILKSIA GKPSHLLTKE
EQAAKIKAEK IRVALEKIKE AQVKKLVIRV HMSDESSKTM MVDERQSVRQ VLDSLLDKSH
CGYSPDWSLV ETITELQMER IFEDHENLVE NLLNWTRDSH NKLMFIERIE KYALFKNPQN
YLLGRKETSE MADRNKEALL EECFCGGSVS VPEIEGILWL KEDGKKSWKK RYFLLRASGI
YYVPKGKAKA SRDLVCFLQL DHVNVYYGQD YRSKYKAPTD YCLALKHPQI QKKSQYIKYL
CCDDVRTLHQ WVNGIRIAKY GKQLYVNYQE AMKRTEAAYD WSSLSTSSIR SGSSSASIPE
SQSNHSGHSD SGVDTASSHG RSQSVVSSIF SEAWKRGTQM EENSKQQQQQ QHPPQPSLMQ
QPTVIQPHRP PSPPQMLPPP PPPPPLPPPP PPLPPLQMVS HHSPAPTMYK YSTITRLQNQ
KTSHKLPATA KQVLPPPLTP PAQVIKPNVN HIAARTNVPP PPPPPPPPSM PTPGSAMAVL
RFGPFNPAAP PSFIPPPPAL HASDMTFPPP PPLPPPVAPT PMRQTVHANG LKQALKERFP
SPPRELLSHN GDLEDSPPPA PAPPPPPPPP PPPPPPPPPP PQQCSIPAQF PPPPGPPQAP
PKTFTPGFMP HTAPKPMSPV SPFPPAPTPT PPLQQGHTHP PPTLPKQHSL TKTVSVSAGA
APTMSLVKQL ASQFPGASSQ VNHAEYPKAP LSPPAVKTKP KWQPGGSQQL LSPEFPPPPA
ESNNSFPAPP PPPTGPTPPP PPLPSGNMGS PLRRSPSGSS SFGGKKPPPA PQRNSSIKAN
SSASYEESRR NLLSKFAPQG NSTPSSPCPI SSFIGSPSKD PSNGPPAPPK PGKLNLSNLP
LALQAKVSQA KQAGGDFPSP PPECAYFPPP PPVSELFPPP PPPGNDVPRV AVVNPQPQAP
PPPPPVSLVS NSIWAKNSLK KTPPPTLGRR SNTTPEPPGI SPPPPTSPKG SSGQPNFLAD
LSQTLKRKSV GRQGPGLPGK LDPVGTMDDM ALPPPPPELL LDQGKQSNGG NDGYMSGNIS
GYATLRRGPP PAPPKRGDAT KLTG
//
