ID M4AEA6_XIPMA Unreviewed; 1740 AA.
AC M4AEA6;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 08-NOV-2023, entry version 58.
DE SubName: Full=TSC complex subunit 2 {ECO:0000313|Ensembl:ENSXMAP00000012800.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000012800.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000012800.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000012800.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR STRING; 8083.ENSXMAP00000012800; -.
DR Ensembl; ENSXMAT00000012816.2; ENSXMAP00000012800.2; ENSXMAG00000012749.2.
DR eggNOG; KOG3687; Eukaryota.
DR GeneTree; ENSGT00950000183139; -.
DR HOGENOM; CLU_001122_0_0_1; -.
DR InParanoid; M4AEA6; -.
DR OMA; CDIMSAI; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0033596; C:TSC1-TSC2 complex; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR003913; Tuberin.
DR InterPro; IPR018515; Tuberin-type_domain.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR InterPro; IPR024584; Tuberin_N.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR PANTHER; PTHR10063:SF0; TUBERIN; 1.
DR Pfam; PF11864; DUF3384; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR Pfam; PF03542; Tuberin; 1.
DR PRINTS; PR01431; TUBERIN.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT REPEAT 489..527
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 1473..1700
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 929..958
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1064..1146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1211..1373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1385..1434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1705..1725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..958
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1068..1086
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1115..1130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1216..1230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1294..1331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1410..1427
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1705..1720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1740 AA; 191824 MW; C8061B1E171E9B2E CRC64;
MNKQQSKETL KEKVKGIFGL GTQRQQTKQC DSKLPEFIIT ADIIKELHPD CGLSNRIRMM
NQICDLAKIK KFEENAVEAV WKAVEDMLSP EQPAEARHAV LQLLRAIIQG QGEWLGPLRA
YFFKVIRDYQ PCNEDLSERL EVFKALTENG KDITYLEEDI ARFVLLWMDI GLTSDFLHVL
VNLVKYNSCY LDQNVSSMVQ KICLLCNRTT SSTDIEVALQ VLDAVVCYNC LPSESLTVFI
ITLCRTVNVK EFCESCWKLM RKVLGTHLGH SAIYTMCRIM EERVYMEDAP LLRGAVFFVG
MALWGAHRLP ALKNTPTLVL PSFYKAMSCA NEVVSYEIVL SITRLIKKYG KELQVVTWDI
LLGIIERLLQ QIQMIGSAEL KAIVYELLTT VEELYEQNGY HGSTEKFFSL VEKCADKRPD
ASVLTLVSYR AQSIQPAKDG WIQSLHCLME KFFRNETRSG IRIKVLHILS FVLSTNRQLY
EDELIEKVVI PQLSGIAEDR DLAVRKQATQ LLVDLAEGCN THHFTSLLDI IERVASRSLV
CSGSLEASDP IADSPMEDVK TAVLGLLEIL QSKLYSLPAS HASRVYELLI SHLQLHYKSK
YCSAIASAVR LQVFDFFLMM RADSLHRVGV PNKDGVMRFS PYCYCDAGEP EKRVCDKKPS
GSISPPAGGP AAAAAAPPAS AASIRSACLP YAPAFSVLLQ CLKMETDWKV LKLVLDKLPW
TLQYKVLLLT SSCSLDQLCS TLCAMISERL KKMPEGFSRT DVQLAVVPVL TAITSYHSYL
DQSRQRELVQ CLETGLIYRC AKQCVVALTM CTVEMPDIMI KLLPALIVKL THISATVAMA
SPMLEFLSTL VRLPHLYANF VAEQYVSVFA ISLPYTNPSK FNQYIVSLAH HVIAMWFIRC
RLPFRKDFVQ YITKGLRSNA LLPFDDGHEQ SPFRARSTSL NERPKRMQTS TTTCSLGSAD
ENAATQADEG LKTVHLELTE TCLDMMARYV FSNFSALPKR SPIAEFLLAG GRSMTWLVGN
KLVTITTSGG VRTQALLGMD MSERLGGGGG EMTRSDPSLH TRMTKEAPAK LESQSSQQQN
RTTRTRVRSR SGGHALRAGP IPSLSPLVSP SEGELASPLS PSSGPTLDGV GPPSSTAAAL
SAPPPLKDNP SLAEFVPMLT QGWAEIFIRR PSGNTSWLMC LENPPSPFSS ELGNMPLQEL
STVLMAMEGV KEPPTQTASA PASTAAPAPT SSAPLEWVEG EEFEPIPSEP IFMSDKAPLP
GPLSRSSSTS SQDDEKSTLE EVSEGAIPID QPSVGPSTPG SQGPDLPFQS HSQSQGHGLN
KSSSSPELQT LPEAFTKAAL ESEKSQGDAA RPRAPSDGGP AQGGEGSGLL SQSGGTAMKL
AFPAAPALPG PISPGGGHRP RGHTISVSAP SSRRERKTER DSYHSRPGPS NAEKLSGLSP
SFVFLQLYHS PFFGNEANKP LLLPKTQVID RAVKVLDQMP PYDTHKIGVV FVGAGQVNNE
VAILSNEYGS NRYAAFLTGL GKLIHLKDCD PDQIFLGGLD QYGDDGEFTY CWHDDIMQAI
FHIATLMPNR ESDKGCCNKK RHIGNDFVMV VYNDSGEDYK LGTIKGQFNF VEVVIKPLDY
ECNLVSLQCR KDLEGLVDTT VAKIVSDRNL PLFVRQMALH ANMASLVHQY RANPSDAYAS
KWLARLRHIK RIRTRVRISL TQGHTGQNKA FQQGASAPTP EMSGQRKRLV STVDDFTDFV
//