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Database: UniProt
Entry: M4AEA6_XIPMA
LinkDB: M4AEA6_XIPMA
Original site: M4AEA6_XIPMA 
ID   M4AEA6_XIPMA            Unreviewed;      1740 AA.
AC   M4AEA6;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   08-NOV-2023, entry version 58.
DE   SubName: Full=TSC complex subunit 2 {ECO:0000313|Ensembl:ENSXMAP00000012800.2};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000012800.2, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX   PubMed=23542700; DOI=10.1038/ng.2604;
RA   Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA   Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA   Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA   Postlethwait J.H., Warren W.C.;
RT   "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT   evolutionary adaptation and several complex traits.";
RL   Nat. Genet. 45:567-572(2013).
RN   [3] {ECO:0000313|Ensembl:ENSXMAP00000012800.2}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000012800.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   STRING; 8083.ENSXMAP00000012800; -.
DR   Ensembl; ENSXMAT00000012816.2; ENSXMAP00000012800.2; ENSXMAG00000012749.2.
DR   eggNOG; KOG3687; Eukaryota.
DR   GeneTree; ENSGT00950000183139; -.
DR   HOGENOM; CLU_001122_0_0_1; -.
DR   InParanoid; M4AEA6; -.
DR   OMA; CDIMSAI; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0033596; C:TSC1-TSC2 complex; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   InterPro; IPR003913; Tuberin.
DR   InterPro; IPR018515; Tuberin-type_domain.
DR   InterPro; IPR027107; Tuberin/Ral-act_asu.
DR   InterPro; IPR024584; Tuberin_N.
DR   PANTHER; PTHR10063; TUBERIN; 1.
DR   PANTHER; PTHR10063:SF0; TUBERIN; 1.
DR   Pfam; PF11864; DUF3384; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   Pfam; PF03542; Tuberin; 1.
DR   PRINTS; PR01431; TUBERIN.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT   REPEAT          489..527
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   DOMAIN          1473..1700
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   REGION          929..958
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1064..1146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1211..1373
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1385..1434
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1705..1725
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        933..958
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1068..1086
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1115..1130
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1216..1230
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1294..1331
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1410..1427
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1705..1720
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1740 AA;  191824 MW;  C8061B1E171E9B2E CRC64;
     MNKQQSKETL KEKVKGIFGL GTQRQQTKQC DSKLPEFIIT ADIIKELHPD CGLSNRIRMM
     NQICDLAKIK KFEENAVEAV WKAVEDMLSP EQPAEARHAV LQLLRAIIQG QGEWLGPLRA
     YFFKVIRDYQ PCNEDLSERL EVFKALTENG KDITYLEEDI ARFVLLWMDI GLTSDFLHVL
     VNLVKYNSCY LDQNVSSMVQ KICLLCNRTT SSTDIEVALQ VLDAVVCYNC LPSESLTVFI
     ITLCRTVNVK EFCESCWKLM RKVLGTHLGH SAIYTMCRIM EERVYMEDAP LLRGAVFFVG
     MALWGAHRLP ALKNTPTLVL PSFYKAMSCA NEVVSYEIVL SITRLIKKYG KELQVVTWDI
     LLGIIERLLQ QIQMIGSAEL KAIVYELLTT VEELYEQNGY HGSTEKFFSL VEKCADKRPD
     ASVLTLVSYR AQSIQPAKDG WIQSLHCLME KFFRNETRSG IRIKVLHILS FVLSTNRQLY
     EDELIEKVVI PQLSGIAEDR DLAVRKQATQ LLVDLAEGCN THHFTSLLDI IERVASRSLV
     CSGSLEASDP IADSPMEDVK TAVLGLLEIL QSKLYSLPAS HASRVYELLI SHLQLHYKSK
     YCSAIASAVR LQVFDFFLMM RADSLHRVGV PNKDGVMRFS PYCYCDAGEP EKRVCDKKPS
     GSISPPAGGP AAAAAAPPAS AASIRSACLP YAPAFSVLLQ CLKMETDWKV LKLVLDKLPW
     TLQYKVLLLT SSCSLDQLCS TLCAMISERL KKMPEGFSRT DVQLAVVPVL TAITSYHSYL
     DQSRQRELVQ CLETGLIYRC AKQCVVALTM CTVEMPDIMI KLLPALIVKL THISATVAMA
     SPMLEFLSTL VRLPHLYANF VAEQYVSVFA ISLPYTNPSK FNQYIVSLAH HVIAMWFIRC
     RLPFRKDFVQ YITKGLRSNA LLPFDDGHEQ SPFRARSTSL NERPKRMQTS TTTCSLGSAD
     ENAATQADEG LKTVHLELTE TCLDMMARYV FSNFSALPKR SPIAEFLLAG GRSMTWLVGN
     KLVTITTSGG VRTQALLGMD MSERLGGGGG EMTRSDPSLH TRMTKEAPAK LESQSSQQQN
     RTTRTRVRSR SGGHALRAGP IPSLSPLVSP SEGELASPLS PSSGPTLDGV GPPSSTAAAL
     SAPPPLKDNP SLAEFVPMLT QGWAEIFIRR PSGNTSWLMC LENPPSPFSS ELGNMPLQEL
     STVLMAMEGV KEPPTQTASA PASTAAPAPT SSAPLEWVEG EEFEPIPSEP IFMSDKAPLP
     GPLSRSSSTS SQDDEKSTLE EVSEGAIPID QPSVGPSTPG SQGPDLPFQS HSQSQGHGLN
     KSSSSPELQT LPEAFTKAAL ESEKSQGDAA RPRAPSDGGP AQGGEGSGLL SQSGGTAMKL
     AFPAAPALPG PISPGGGHRP RGHTISVSAP SSRRERKTER DSYHSRPGPS NAEKLSGLSP
     SFVFLQLYHS PFFGNEANKP LLLPKTQVID RAVKVLDQMP PYDTHKIGVV FVGAGQVNNE
     VAILSNEYGS NRYAAFLTGL GKLIHLKDCD PDQIFLGGLD QYGDDGEFTY CWHDDIMQAI
     FHIATLMPNR ESDKGCCNKK RHIGNDFVMV VYNDSGEDYK LGTIKGQFNF VEVVIKPLDY
     ECNLVSLQCR KDLEGLVDTT VAKIVSDRNL PLFVRQMALH ANMASLVHQY RANPSDAYAS
     KWLARLRHIK RIRTRVRISL TQGHTGQNKA FQQGASAPTP EMSGQRKRLV STVDDFTDFV
//
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