ID M4AEK0_XIPMA Unreviewed; 635 AA.
AC M4AEK0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Elongation factor for RNA polymerase II {ECO:0000313|Ensembl:ENSXMAP00000012894.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000012894.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000012894.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000012894.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ELL/occludin family.
CC {ECO:0000256|ARBA:ARBA00009171, ECO:0000256|PROSITE-ProRule:PRU01324}.
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DR AlphaFoldDB; M4AEK0; -.
DR STRING; 8083.ENSXMAP00000012894; -.
DR Ensembl; ENSXMAT00000012910.2; ENSXMAP00000012894.2; ENSXMAG00000012869.2.
DR eggNOG; KOG4796; Eukaryota.
DR GeneTree; ENSGT00940000155914; -.
DR HOGENOM; CLU_021268_0_0_1; -.
DR InParanoid; M4AEK0; -.
DR OMA; DECVPEP; -.
DR OrthoDB; 2910197at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0008023; C:transcription elongation factor complex; IEA:InterPro.
DR GO; GO:0006368; P:transcription elongation by RNA polymerase II; IEA:InterPro.
DR Gene3D; 6.10.140.340; -; 1.
DR Gene3D; 1.10.10.2670; E3 ubiquitin-protein ligase; 1.
DR InterPro; IPR042065; E3_ELL-like.
DR InterPro; IPR031176; ELL/occludin.
DR InterPro; IPR019464; ELL_N.
DR InterPro; IPR010844; Occludin_ELL.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23288; OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL; 1.
DR PANTHER; PTHR23288:SF9; RNA POLYMERASE II ELONGATION FACTOR ELL; 1.
DR Pfam; PF10390; ELL; 1.
DR Pfam; PF07303; Occludin_ELL; 1.
DR SUPFAM; SSF144292; occludin/ELL-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51980; OCEL; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 525..635
FT /note="OCEL"
FT /evidence="ECO:0000259|PROSITE:PS51980"
FT REGION 165..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..465
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..482
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 635 AA; 70219 MW; A92444EDD671F500 CRC64;
MAALKEEQCY GLSCGRVSNG SNVTVFHVKL TDSALRALEG FRSSKILSQQ PFVRFNGNQG
KISIPRSETS SELQTFTFDL SNVGRDNPQG SFDCIQQYIT SEGGIQLDCL GSIQDKITVR
ATDDSYQKAR ESMAQAEETT RSRSAIVIKP GGRYVGKKVQ IRKPAPALSD VAPSRRTSRP
VLISSSTQKK ATTQHRPLRE RLVHLLALKP YKKPELILRL QKDGLSQLDK ESLDSHLQQV
ANLNGKENTF TLKDFMYKEV QKDWPGYTEG DQQLLKRILF RKQAQTSSAP VPESPPKELG
SSSPSQKRPT VDFIDPLANK KPRISHLASK AATVQMNGKL GSSCGRGDPG AALSGAAVST
SESGMTSGSQ PLPVLDIPRP FEALSDVSND SSNNGRDGDS QETTLSERLS QPPSLLSVST
VASAPSLGTS SSGHTVLEGP QDNGPSAVNN KSRKKSKKHK DKEKSKDKGK GRAKEKKICQ
EPASEPKTAC EMSLKLFKNS VAFKSTDLNG MCKTTSILSS SPEVADYLLK YTVITSPEQR
QRYKNDFNAE YSEYRGLHAR IEGITRQFTV LDNELKQLQQ GTDKYKSIHN QILQEYHKIK
KTNPNYSQEK NRCEYLHNKL AHIKKLIAEY DHQQL
//
