ID M4AFA7_XIPMA Unreviewed; 624 AA.
AC M4AFA7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Forkhead box O4 {ECO:0000313|Ensembl:ENSXMAP00000013151.2};
GN Name=FOXO4 {ECO:0000313|Ensembl:ENSXMAP00000013151.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000013151.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000013151.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000013151.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR RefSeq; XP_014324429.1; XM_014468943.1.
DR AlphaFoldDB; M4AFA7; -.
DR STRING; 8083.ENSXMAP00000013151; -.
DR Ensembl; ENSXMAT00000013167.2; ENSXMAP00000013151.2; ENSXMAG00000013124.2.
DR GeneID; 102219634; -.
DR KEGG; xma:102219634; -.
DR CTD; 4303; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000159334; -.
DR HOGENOM; CLU_023456_1_1_1; -.
DR InParanoid; M4AFA7; -.
DR OMA; APSCFPS; -.
DR OrthoDB; 5385885at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd20062; FH_FOXO4; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047409; FH_FOXO4.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR032067; FOXO-TAD.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45767; FORKHEAD BOX PROTEIN O; 1.
DR PANTHER; PTHR45767:SF3; FORKHEAD BOX PROTEIN O4; 1.
DR Pfam; PF00250; Forkhead; 1.
DR Pfam; PF16676; FOXO-TAD; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 101..195
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 101..195
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 1..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 605..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..624
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 624 AA; 65381 MW; 242C596F4B610E49 CRC64;
MEESSMPPID PDFEPQSRPR SCTWPLPRPD ISAVKVEGAD GAESAAGTPP AADEDKPEPQ
QIISEPEKAA AAAAAEEGGV VAGVGGAGAT PRKGSSRRNA WGNQSYADLI SQAIENSPEK
RLTLAQIYDW MVKTVPYFRD KGDSNSSAGW KNSIRHNLSL HNKFLRVHNE STGKSSWWML
NPEGGKTGKA PRRRAVSMDN SSKLLKSRIR AKQTKKQAGA AGGGGVLQGD GGGGSAGAES
PNSSQQFPKW GVNSSSPSSR GSLDDADMWT TFRPRTSSNA STLSGRLSPI APGQEDDDSL
PDDGLLGRYA SSSLTPTLTE TVMEELDLID NLTLMTAQQG AASPSTAPPA PPTPLPSAST
LLPRGSGFTS FHQAHSAAQP AVSLKEPPAS FSNSLFNPMS SSSAHGGGHY GGHVPSSLEV
LLTSDSPPPS DVLMAQVGPL MANSGGLGQM GLGVRAKPAQ LQLNKALEAN AVAPMAMQTQ
MQPTPQQHFR HNHQQHQIGL GMILSGLSQD PTPLSALKTH QVQTISAHHT APAPAPAANQ
SLSLPAVGPF GAPTGFQPGQ ERLPTDLDID MFTENLDCDV DYIINSDLMD GDGMDFNFDP
ILPGGQGYTG PTNTQGSAHS WVPS
//
