ID M4AFK9_XIPMA Unreviewed; 1510 AA.
AC M4AFK9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=FYVE and coiled-coil domain containing 1 {ECO:0000313|Ensembl:ENSXMAP00000013253.1};
GN Name=FYCO1 {ECO:0000313|Ensembl:ENSXMAP00000013253.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000013253.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000013253.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000013253.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 8083.ENSXMAP00000013253; -.
DR Ensembl; ENSXMAT00000013269.2; ENSXMAP00000013253.1; ENSXMAG00000013225.2.
DR eggNOG; KOG1729; Eukaryota.
DR GeneTree; ENSGT00940000154044; -.
DR HOGENOM; CLU_004445_0_0_1; -.
DR InParanoid; M4AFK9; -.
DR OMA; ELGMSIC; -.
DR OrthoDB; 5394846at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15726; FYVE_FYCO1; 1.
DR CDD; cd17698; RUN_FYCO1; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 2.60.120.680; GOLD domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR047337; FYVE_FYCO1.
DR InterPro; IPR009038; GOLD_dom.
DR InterPro; IPR036598; GOLD_dom_sf.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR047336; RUN_FYCO1.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46753; FYVE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46753:SF2; FYVE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR SUPFAM; SSF101576; Supernatant protein factor (SPF), C-terminal domain; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS50866; GOLD; 1.
DR PROSITE; PS50826; RUN; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 34..167
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 1199..1257
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 1382..1498
FT /note="GOLD"
FT /evidence="ECO:0000259|PROSITE:PS50866"
FT REGION 1270..1364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 235..781
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 811..866
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 948..1084
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1145..1172
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1278..1292
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1321..1339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1510 AA; 171269 MW; EB0F27C490CA76A6 CRC64;
MAVGESQLQR IIRDLHDAVA ELAKEYKESG EPITDDSVNL HKFSYKLEYL LQFDQKEKTT
FLGTKKDYWD YFSDCLAKIK GANDGIRFVK SISELRTSLG KGRAFIRYSL VHQRLADTLQ
QCLMNQRVTS DWYYARSPFL KPHLSSDIIN HLYELNEVQF DVASRGHDLD ASWPTFARRT
VGSANSPGHM WKAPSRSSSI NSLASSYSQQ APECASSPDY GQSLLNDLND SLPACMEDNN
TVENLRLELD QSELRQRDLL DKVQQLGEES GELKGVIEEL QRQLDVSLAA QEGHQGLQEE
LRALQGRDVA LTRQVEALRA EEKAKETQLV LLQEKLAAAE QKNMELMAKL DGFLDEKGQQ
AASHFDSALK IHELLDKLKE AEKVKMEAEA KMVENRRQVE RLEEEVQVNE MKSKENERKL
EALVTSLSEE KAKLNAKVEE QFSTLEKLQG DLALREKDAN NLQRQLQNIQ QSLKEKEQEL
EEVKKGAKQE IEEMQKNVDD LKESLEGKVA EITVQLTNRE AELISSSETL QKLEAKNQIL
TTERDELTTS LNQHKTKINK QAAKIEDYQT QCASLQELKE KLQATVSRNE EQQNEMTEDR
AALQAELAAL RASEKQLRGQ VDNAKMTVDE KEKVLREENR SLDESLQRVT MAAKQSEMTS
KRLEQENQTL REELDDLKAT LSRIETNLKN GRIQIEEHKK NLEASNTKLV SLQEQLSAKE
EQLENKEKEV VKLMSTLQEL EAKEKENEMA KANAETTCAK QAELIERITS EKQAIETLQL
ERSSVQAKEN QEVTVKLTVV EGQLEVSMKE VSRLQAKILD LKVQVQRSEE EKLKSHAQLE
VTVAQRDELR CLTEQLKSQA EELNQKHIAE LLECKKKEEA LAQQRDREAA AHAELAISSS
AVREELAALK AENNKLALEN TEIREGLHRA NTEMAELGMS ICKLNAEREE ASEHLAGDAA
KIEELEKEVE RIEECMNDLR QENNSLREEL TQKESLPRAI TELQEELEKA KNQVHSIKEC
CQEEMDAVKF QMSSETMSHQ AQIKAVTENL EKISAQLEEE QKNVSSLEAE VSELKAANEK
YLQLIGEKDA YITQAEATIR DNEGKIQQLS SSTASIEEAH LSMQTLCEEL KQKFKATEAE
KQSQYLTMSA EIEDLNSTKI NLEERLIELI KDKDALWQKS DALEFEQKLR AEERWWLVDK
EATHCLDCND QFTWWVRRHH CRVCGRIFCY NCSNNFVLTK HSGKKERCCR DCYMQHNAVV
EKFVESEMSS SDVLPSPARA GPQPPPEPAP YKSPSSATVS DTGIKSDDGG YDIITEEEVN
GVYDSDSNSQ TTGGSLEGEQ DRQQPGAREI GPGEVAPDDD SVPTVQDSEI NLLRSGDVTL
TVPLSVEDIS QFGDGSRELF IKSSCYSTIN ITVTDCETTI GWMFSSEPRS ISLGVVYRES
SDSDVEQAKV LIPLTRCNSH KEKIQGQVKA RHPGLYTLIF DNSFSRFISK KVFYHLTMEK
PVIYDGSDGP
//
