ID M4AHI2_XIPMA Unreviewed; 386 AA.
AC M4AHI2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Growth/differentiation factor 15 {ECO:0000313|Ensembl:ENSXMAP00000013926.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000013926.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000013926.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000013926.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; XP_005811118.1; XM_005811061.1.
DR AlphaFoldDB; M4AHI2; -.
DR STRING; 8083.ENSXMAP00000013926; -.
DR Ensembl; ENSXMAT00000013944.2; ENSXMAP00000013926.2; ENSXMAG00000013897.2.
DR GeneID; 102218734; -.
DR KEGG; xma:102218734; -.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00940000161872; -.
DR HOGENOM; CLU_064099_0_0_1; -.
DR InParanoid; M4AHI2; -.
DR OMA; EYTMHFC; -.
DR OrthoDB; 3015718at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19376; TGF_beta_GDF15; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF78; GROWTH_DIFFERENTIATION FACTOR 15; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 272..386
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 386 AA; 43723 MW; 542950ACAC8E9EAF CRC64;
MDKPIPQWWS TYKSTLASRL TMLTSHTPAL LASYTLLLLL VPTSGVLQPD VARQGLLETS
NVDDRGPLIL ETVKKGILGS LGLDKEPKPA MKASQRELRK MFKLYREKIS EMRRNSSQSV
RETWQSNTST VLFPAEPLHV LRKGDQRHIV WYRAVFQKNP KIHSELTMAQ AQLKVSGSGL
GNNPKTRRYI KVKINGMKPR NSAAWTYNDS NSMIPRVTLD ISPEASRGMW IDDQVLVVDV
GMAPLSRKAS KLKPTVTLEL GLKDSVPSRG GRWRRSNKED HCDERGWCCR KSATVSFKDI
GWTDWVVAPT EYTMHFCDGT CPHNYKPASM HTQVKSRLHQ ITKGEMPRPC CVPAAYEPMV
LMHYDSRGKL KLTLFNDFIV TKCHCA
//
