ID M4AHY0_XIPMA Unreviewed; 2895 AA.
AC M4AHY0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=LPS responsive beige-like anchor protein {ECO:0000313|Ensembl:ENSXMAP00000014074.2};
GN Name=LRBA {ECO:0000313|Ensembl:ENSXMAP00000014074.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000014074.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000014074.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000014074.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSXMAT00000014093.2; ENSXMAP00000014074.2; ENSXMAG00000014034.2.
DR eggNOG; KOG1787; Eukaryota.
DR GeneTree; ENSGT00940000154778; -.
DR HOGENOM; CLU_000218_2_2_1; -.
DR InParanoid; M4AHY0; -.
DR OMA; NERGPWG; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046851; NBCH_WD40.
DR InterPro; IPR010508; NBEA-like_DUF1088.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR046852; Neurobeachin_a-sol.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF64; LIPOPOLYSACCHARIDE-RESPONSIVE AND BEIGE-LIKE ANCHOR PROTEIN; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF06469; DUF1088; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF20426; NBCH_WD40; 1.
DR Pfam; PF20425; Neurobeachin; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 2102..2210
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2229..2518
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2667..2702
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 928..1002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1015..1316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1332..1369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1624..1705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1807..1834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2075..2106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 928..960
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..1002
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1032..1046
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1047..1072
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1087..1101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1137..1162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1170..1218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1240..1259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1267..1284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1681..1704
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2895 AA; 320857 MW; E7AFB2EABD32456C CRC64;
MASAEAAEPG DGKDGRAGAM QLNPTVPIRG IRMKFAVLAG LVEVGEVSNR DIVETVFNLL
VGGQFDLEMN FIIQEPESIV CMVELLDKCE PTCQAEIWSI FTAILKKSVR NLQVCTEVEL
IQQVLHRIST TDSMIADLLV DMLGVLASYS ITVKELKLFF SKLQGEQGQW PRHAVKLLSV
LKYMAHRNGP DSFFSFPGKN AAAIALPPIA RWPYQNGFTF HTWIRMDPLN NINVDKDKPY
LYCFRTNKGM GYSAHFVGGC LIVTSLKSKG KGFQHCVKYD FKPQKWYMVT LVHVYNRWKN
SEISCFVNGE LASYGDIAWF VNTSDTFDKC FLGSSETADV NRVFCGQMGA VYLFAEALSA
AQILAIYQLG PGYQGTFKHR AESDLLFEEH HKTLLYDGKL ASGIAFTYNP CATDAQLCLE
SSPKDNASIF VHSPHALMLQ DVKAVVTHSV QSGIHSIGGI QVLFPLFAQL DYWQPCSQEP
DTSVCCTLLS FMMELLKNSV SMQEQVLACK GFLVIGYTLE KSSKVHVTRP VLDIVLAFSR
YLSNLQNGIY LLKQLCDHIL FNPAIWIHAP AKVQLMLYTY LATEFISTVT IYNAVRRVGT
VLQVMHTLKY FYWVVNPHDR SGVIPKGVDG PRPNQKEMLS LRAFLLLFIK QLIMKDHGVK
EDELQSILNY LLTMHEDENL MDVLQLLVAL MSEHPGTMVQ AFDQRNGIRV IYKLLASKNE
GIRIQALKVM GYFLKSLSAK RKSEVMLTHG LFSLLTERLM LHSNPFTMTT YNSLFEILTE
QICTQVIHKQ HPDPDSSVKI VNPQMLKVIA ALLKNCPQSP ESMEVRRVFL SDMIKLFNNS
RENRRSLLQC SVWQEWMLSL CFVSPSNNEE QKITEMVYAV FRILLYHAIK YEWGGWRVWV
DTLSITHSKV TFEQHKESLS RMFRQYQHQG STSSRSTIRT ISGVSQISED TKSVNGSPAE
EMAPSTVVEL TVDEGSQKSL RSTSGSTITP MPVEAAEDRN QSSVTVSNIL AGAEEEQKVE
FSSGDQSNVD KETSTAVHKD EVTEPASEKS SQNAETSVNT QSEASGPTTK EDSAAPTKDD
AQTEVAHLEQ GDSSELSTEE ASVASEKGDE SKQMSSEPPA PLENSVLGGA SVFNEDLVDV
SSVSDQINPS DVDDSQEESS YASAAAGEEG ESVKKAEDER EGDGSKTKDL GEQEPKTEEG
KQETETVRRE EQEKDSVENQ VPCSESPAPE TEVADQSVKE PTKENVSGPE SSSKSEGAAS
DRQEAAAPEA TPQSQPSESS MSAAEETPPH AHDTSTPGSS TSKTPDPARK TKETKIARLD
VANVAVDTER LELKETSITE SSQGQTTGAA GEAGSPPGRP EDSSTSAPRS TMFRIPEFRW
SHMHQRLLTD LLFSIETDVQ AWRSHSTKTV LDFVNSSENT VFVHNSIHLV SQVVDNLIMA
CGGILPLLSA ATSASHELEN IEPSQGLPVE ASVTFLQRLI NLADVLIFAS SLNFTEIEAE
KNMSSGGILR QCLRLVCAIA VRNCLECQQA QFKGAEGPTR SYTVMPSTAV GTAKSASAQS
PVDAVTGGMS TVRDLDRLLQ DMDINRLRAV VFRDIDSKQA QFLALAVVYF ISVLMVSKYR
DILEPHNDRK PPLRSQSTRS TDSSAEVENG VSLRRYDSGI GDDHTSAVAS EADLSSSGGP
DAVSEALSTL SSEVRGSTSA DSKSKNVKDI LRSLVSSPAE DVMVDPSLLP LSFMGPVTHL
DRRSSLQFRS FDRSVVVAPR QAGVLPSQVS PAPAQTSAAA SVSAGTPVDG VAVVSSGDAS
QVLSVDAADS GGQVPASSSL PSVPPLSPVT QNTAPNMSIS ERLEHALEKA APLLREIFVD
FAPFLSRTLL GSHGQELLIE GTSLVCMKSS SSVVELVMLL CSQEWQNSIQ KNAGLAFIEL
VNEGRLLSHT MKDHLVRVAN EAEFILSRQR AEDIHKHAEF ESNCAQYAAE KRDEEKMCDH
LIRAAKFRDH MTSTQLIQKI VNILTDKHGA WGSSSVSRPR EFWRLDYWED DLRRRRRFVR
NPFGSSHSEA ALKAAAEHAS EDDILKQSIR SQALANQNTE SEASLDGDDD TLSSLEDKDL
ENQTGPVNLS TSAQLVAPAA VVKGTLSVTA SELFFEVEED DPSYKAVDPK ILSYTEGLHG
KWLFTEIRAV FSRRYLLQNT ALEVFMANRT AVMFNFPDAA TVKKVVHSLP RVGLGTNFGL
PQIRRISLAT PRQLFKTSNM TQRWQRREIS NFEYLMFLNT IAGRTYNDLN QYPVFPWIIT
NYESPELDLT LPSNYRDLSK PIGALNPKRA AFFSDRYESW EDDQVPKFHY GTHYSTSSFT
LMWLLRIEPF TTFFLNFQGG KFDHADRTFS SVFRAWRNCQ RDTSDVKELI PEFFYLPEMF
VNANNYNLGV MEDGTVVSDV DLPPWAKSSE EFVRINRQAL ESEFVSCQLH QWIDLIFGYK
QQGPEAARAL NVFYYLTYEG AVNLSSINDP MLREAVESQI RSFGQTPSQL LIEPHPPRSS
AMQVYLLLQT PLMFTEQMQQ DVIMVLKFPS NSPVTHVAAN TQPGLASPAI ITVTANRLFS
VNKWHGLAGH QNAGEQQYQL PVEIDPLIAS NVGCHRRQIS DLLDQSIQIS SQCFVITADN
RFILLCGFWD KSFRVYSTDT GKLTQIVFGH RDVVTCLARS ESYIGGDCYV LTGSRDATLL
LWYWNGKLSS IGESPGKFTT PRAILTGHDC EVTSVSVCAE LGLVISGCKE GPCLVHSMNG
DLLRTLEGPE SCLRPQLIQS SSEGHCMIYY DKGHFCLFSV NGKLLRHMEV QDNIKAMLLS
RDGQYLLTGG DGGVVSVWQV SDLKQLFTFP GCDAGIRSMA MSHDQRCIIT GMASGSIVLF
YNDFNRWHHE YQTRY
//
