ID M4AII8_XIPMA Unreviewed; 475 AA.
AC M4AII8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Zinc transporter SLC39A7 {ECO:0000256|ARBA:ARBA00039859};
DE AltName: Full=Solute carrier family 39 member 7 {ECO:0000256|ARBA:ARBA00042780};
DE AltName: Full=Zrt-, Irt-like protein 7 {ECO:0000256|ARBA:ARBA00043053};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000014282.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000014282.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000014282.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351,
CC ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00034634};
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004257}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004257}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC KE4/Catsup subfamily. {ECO:0000256|ARBA:ARBA00038485}.
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DR AlphaFoldDB; M4AII8; -.
DR STRING; 8083.ENSXMAP00000014282; -.
DR Ensembl; ENSXMAT00000014302.2; ENSXMAP00000014282.1; ENSXMAG00000014253.2.
DR eggNOG; KOG2693; Eukaryota.
DR GeneTree; ENSGT00940000157349; -.
DR HOGENOM; CLU_015114_0_1_1; -.
DR InParanoid; M4AII8; -.
DR OMA; IWLHSIG; -.
DR OrthoDB; 5488029at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR002395; Kininogen.
DR InterPro; IPR003689; ZIP.
DR PANTHER; PTHR16950:SF25; ZINC TRANSPORTER SLC39A7; 1.
DR PANTHER; PTHR16950; ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4; 1.
DR Pfam; PF02535; Zip; 1.
DR PRINTS; PR00334; KININOGEN.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..475
FT /note="Zinc transporter SLC39A7"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004047701"
FT TRANSMEM 160..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 26..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..152
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..321
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 475 AA; 50803 MW; AE4921738362E8A5 CRC64;
MGCLRLLTLT LAASAALLLT SQSATAHSHS HDDHGHDDHG HNHHHHGHSH GEDDGHSQGA
RVKMFHGASK WSAEANLPQH EEEQHHHGHG HAHSHDHGHA HSHDHGHAHS HDHGHAHSHD
HGHAHSHDHG DTRSHGHGHS HGAERAKREA DGEKRDLVEL WTQAIGATLL ISAAPFLILF
LIPVQSNSDQ HQNLLKVLLS FASGGLLGDA FLHLIPHALE PHSHHGEGDE EHASEESHDH
GHSHGAAHGH MMSVGLWVLG GIIAFLVVEK FVRLLKGGHG HSHSHSHAAA KEKDSDGEEE
KEKKTKEKKT KKGVKAAEPE EKKGTEIKVS GYLNLAADFT HNFTDGLAIG ASFLVSPAVG
AVTTLTILLH EVPHEIGDFA ILVQSGCTKK KAMCLQLLTA VGALAGTACS LLAEGVGATA
TAWILPFTAG GFVYIATVTV LPELLVGRAS FGQSLMEILA LLFGVGMMVL IAEYE
//
