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Database: UniProt
Entry: M4AIX3_XIPMA
LinkDB: M4AIX3_XIPMA
Original site: M4AIX3_XIPMA 
ID   M4AIX3_XIPMA            Unreviewed;      4870 AA.
AC   M4AIX3;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   16-JAN-2019, entry version 39.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSXMAP00000014417};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSXMAP00000014417};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000014417, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Ensembl:ENSXMAP00000014417}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000014417};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSXMAP00000014417}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000014417};
RX   PubMed=23542700; DOI=10.1038/ng.2604;
RA   Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA   Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA   Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA   Postlethwait J.H., Warren W.C.;
RT   "The genome of the platyfish, Xiphophorus maculatus, provides insights
RT   into evolutionary adaptation and several complex traits.";
RL   Nat. Genet. 45:567-572(2013).
RN   [3] {ECO:0000313|Ensembl:ENSXMAP00000014417}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000014417};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   STRING; 8083.ENSXMAP00000014417; -.
DR   Ensembl; ENSXMAT00000014437; ENSXMAP00000014417; ENSXMAG00000014335.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00940000154906; -.
DR   InParanoid; M4AIX3; -.
DR   OMA; RFSMKDT; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002852};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4184   4207       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4407   4428       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4474   4496       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4671   4692       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4747   4770       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       82    137       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      144    189       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      197    252       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      258    308       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      323    380       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      583    781       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      993   1190       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1301   1518       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3939   3965       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      444    464       {ECO:0000256|SAM:Coils}.
FT   COILED     2809   2829       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4870 AA;  553196 MW;  25F0026A9046B6D3 CRC64;
     DDEVVLQCSA TIQKEQQKLC LAAEGFGNRL CFLESISNSK NVPPDLSICT FVLEQSLSVR
     ALQEMLASTE EKAEGAAQGG GHRTLLYGHA VLLRHSYSGM FLCCLSTSRS STDKLAFDVG
     LQEETTGEAC WWTIHPASKQ RSEGEKVRVG DDLILVSVSS ERYLHLSYGN GSLQVDAAFQ
     QTLWSVAPIC SGSEVAQGFL IGGDVLRLLH GHMDECLTVP SGEHGEEQRR SVHYEGGAVS
     SHARSLWRLE TLRVMWSGSH IRWGQPFRLR HVTTGKYLSL TEDKSLLLMD KEKADVRSTA
     FCFRLSKEKL DPGVRKEVDG MGTPDIKYGD SVCYIQHVNT SLWLTYQTID AKCARMGGVQ
     RKAIMHHEGH MDDGLTLSRS QHEESRTARV IRSTVFLFNI FIRGLDTVRK KGKSSTLDLP
     IDSVSLSLQD LIGYFQPPED HLDHEDKQNR LRALKNRQNL FQEEGMISLV LECIDRLHVY
     SSAAHFAEVV GREAAEAWSS ILNSLYQLLA ALIRGNRKNC AQFSGSLDWL ISRLERLEAS
     SGILEVLHCV LVESPEALNI IKEGHIKSII SLLDKHGRNH KVLDVLCSLC VCNGVAVRSN
     QHLICDNLLP GRDLLLQTRL TNHVSSMRPN IFLGVSDGSA QYRKWYYELI VDQTVPFVTS
     EPTHLRVGWA NTSGYAPYPS GGEGWGGNGV GDDLYSYGFD GLHLWSGCIA RTVTSPNQHL
     LRSEDVVSCC LDLSIPSISF RINGQPVQGM FENFNSEGLF FPVASFSAGV KVRFLLGGRH
     GEFKFLPPSG YAPCFEAVLP REKLKLEASQ DQTVARDLLG PTVTLSQAAF TPTPVDTSQI
     VLPSHLERIR EKLAENIHEL WVMNKIELGW TYGVVRDDNK RQHPCLVEFS KLPEQERSYN
     LQMSLETLKT LLALGCHVGL ADEHAVEKVK SMKLSPTYEL SSGYKPAPLD LGHIKLTPTQ
     EAMVDKLAEN AHNVWARDRI RQGWTYGIQQ DVKNRRNPRL VPYMLLDERT KKSNKDSLRE
     AVRTLLGYGY NLEAPDQDHA AQSDVSNVSA ERFRIFRAEK TYCVNTGKWY FELEVLTAGE
     MRVGWARPGC LPDQELGSDD QAFVFDGFKV QRWHQGNEHF GRAWQTGDVV GCMVDLNEHT
     MMFTMNGEVL LDDSGSELAF KDFEVAEGFI PVCSLGMCQV GRMDFGKDVS TLKYFTICGL
     QEGYEPFAVN MNRDVTMWLS KRLPQFVPVP PNHQHIEVTR MDGTVESCPC LKVTQRSFGS
     QNSYNDITFY RLSMPIECAE SRSPSYGSLF SPKRELEDFE TVSDFEVLLK SSHGPNGPSG
     HDRDEFNNHK DYTQEKPSKL KQRFTLKKNK PDNSCPSSAR LSEEVAVDDR EGYEVLMQAS
     TYYYSVRIFP GQEPSSVWVG WVTSDFHQYD PSFELSKVRT VTVTLGDEKG KVHESIKRSN
     CYMVWAGESS SPGQGRNNNG LEIGCLVDTT NGLLSFTANG KELSMYYQVE PSTKLFPAVF
     AKATSPNVFQ FELGRIKNVM PLSAGLFKSE RKNPAPQCPP RLHVQFLTPV LWSRVPNHFL
     KVSASRVNDR HGWQVQCSDP LQFMSLHIPE ENRSVDILEL SEQKDLLKFH YHTLRLYSAI
     CALGNNRVAH ALCSHIDEAQ LLQAIENKYM PGLLRAGYYD LLIDIHLRSY ATARLMMNNE
     YIVPMTHETK SITLFPDDLK KHGLPGIGLS TSLRPRMHFS CPSFICVTDC FQYSPEFPLD
     ILKVKTIEML TEAVREGSMH VRDPVGGSTE LLFVPLIKLV YTMLIMGIFQ NGDLKNILQL
     IEPSVFSEPR DEQEELPREL EMLKNVETAG RGEDGGRNLP KEGLLQMKLP EPVKLQMCHV
     LQYLCDCQVR HRIEAVVAFS DDFVACLQDN QRFRYNEVML ALNMSAALTA KKTKEFRSPP
     QEQVGKSPWQ HVTHCGLKLD EERGIDGDSD FTIRGRLMSL VEKVSYLKKK MGSLPKEKKD
     RKPSTLQQLI SDTMVRWAQE SVIEDPELVR AMFVLLHRQY DGIGGQVRAL PKAYTINSVS
     IEDTINLLAA LGQIRSLLSV RMGREEEKLM IRGLGDIMNN KVFYQHPNLM RALGMHETVM
     EVMVNVLSGG DSKEITFPKM VANCCRFLCY FCRISRQNQK AMFDHLSYLL ENSSVGLASP
     SMRGSTPLDV AAASVMDNNE LALALREPEL EKVVQYLAGC GLQSCVMLLH KGYPDIGWNP
     VEGERYLDFL RFAVFCNGES VEENANVVVR LLIRRPECFG PALRGEGGDG LLAAMEEAIR
     ISQDPCRDGP SPVSESSRTL DMLDEEEDDT IHMGNAIMTF YSALIDLLGR CAPEMHLIHA
     GKGEALRIRA ILRSLIPIDD LVGVISIPFS MPNLAKDGIV VEPDMSAGFC PDHKAAMVLF
     LDRVYGIEDQ NFLLHLLEVG FLPDLRAAAS LDTAALSATD MALALNRYLC TAVLPLLTKC
     APLFAGTEPF ASLIDSLLHT VYRLSKGCCL TKAQRDAIEE CLLAVCGKLR PSMMQHLLRR
     LVFDVPLLNE HTKMPLKLLT NHYERCWKYY CLSGGWGSFG VASDEELHLS RKLFWGIFDA
     LSCKRYDQEL FKLALPCLSA VAGALPPDYM ESNYMALMEK QSSMDSEGNF NPQPADTTNV
     TVPEKLDYFI TRYAEHNHER WCIEKFSFGW TYEEHLCESS KTHPLLKPYK ALSEKDKEAY
     CWSVRESLKT MLSWGWSIDR NREGDTATLH NKSRRISMAS QVLSFEGAPA FSPRPVDMSN
     VTLSRDMQSM AELLAENYHN IWARQKKMEL EAKGGGRHPL LVPYDTLTAK EKSKDREKAQ
     DILKFLQING YIVSRGKKSP ELDTPAIEKR FAYTFLQKLI TYVDQAHQHM MEFDVGANLK
     GGKIPHEQQI KFFGKVVLPL VDQYFKNHRL YFLSTAIHAI SSGGHASNKE KEMVTSLFCK
     LGVLVRHRIS LFGNNATSIV NCLQILGQSL DARTVMKTGL ESVKAALRSY FDSVAEDLEK
     TQENLKLGQF THSREQPRGV TQIINYTTFA LLPVLSSLFE HIGQNMFGED LMLDEVQVSC
     YRILNSLYFL GTNKSIYVER QRPALGKCLA AFSAAFPVAF LEPQLNKFNS FSIYNNKASK
     DRTALGLPGP VGEVCRLVPN LEKSLEEIME LAESGMKYTQ MPHVMEVVLP MLCSYMSHWW
     EHGPESNPDE DDSCCTSVAS EHMNTLLGNI LKIIYNNLGI DEGAWMKRLA VFSQPIISKA
     KVQLLQTHFL PLMDKLRKKA AVVLMDEEQS RAEGRGEMSE TELLIMDQFT ILVRDLYAFY
     PLLIRFVDYN RYRRWLKESN PEAEELFRMV AEVFIFWAKS HNFKREEQNF VVQNEINNMS
     FLISDTKCKM SKGIVSDQER KKMKRKGDRY STQTSLIVAT LKRLLPVGLN ICAPGEQELI
     ALAKNRFTQK DTEDEVREII RNNLHLQGKL EDPAIRWQMA LYRDLPYHYE DTSDPEKTVK
     RVLDIAHVLF HLDQVLIIGL HVEHPQRSKK AVWHKLLSKQ RKRAVVACFR MAPLYNLPRH
     RAVNLFLQGY EKSWIEAEEH YFEDKLIEDL AKAGEREPSE EEEGIKHIDP LHQLIQLFSR
     TALTEKCCHD EEDEEGEVKS FEEKEMEKQK LLYQQARLHD RGAAEMVLQT ISASKGVMGP
     MVASTLKLGI AILNGGNSTV QQKMLDYLKE KKDVGFFQSL AGLMQSCSVL DLNAFERQNK
     AEGLGMVTEE GSGEKVMQDD EFTCDLFRFL QLLCEGHNSD FQNYLRTQTG NNTTVNIIIS
     TVDYLLRVQE SISDFYWYYS GKDVIDEQGQ RNFSKAINVA KQVFNTLTEY IQGPCTGNQQ
     SLAHSRLWDA VVGFLHVFAH MQMKLSQDSS QIELLKELMD LQKDMVVMLL SMLEGNVVNG
     TIGKQMVDML VESSNNVEMI LKFFDMFLKL KDLTSSDGFK EYDPDGKGVI SKRDFHKAME
     SHKHYTQSET DFLLSCAETD ENELLDYEEF VMRFHEPAKD IGFNVAVLLT NLSEHMPHDT
     RLQTFLELAE SVLNYFQPYL GRIEIMGSAK RIERVYFEIS ESSRTQWEKP QVKESKRQFI
     FDVVNEGGEK EKMELFVNFC EDTIFEMQLA AQMSDAGERS AVKEESEREK CDEENPDMGF
     FSVSTVRLAL IALRYNVMLL IKVLSMKSLK KQMKKIKNMT LKDLVTTLVS FYWSVLLGLL
     HVAFSVARGF CRIFYNTFMG GNLVEGAKAV KVSELLATMP DPTQDEVRGE GDEREKRLSE
     RSSPKEDLAD LAVNTSETEL LSDIFGLDLR REGGQYKITP HNPNATLTEL LSSPVPPSAP
     PPAPQPELRQ RHQVNETFSA LGLFIMYIHL EEHVVKQEKQ VKNEKMKSKV RKHHNSKSDE
     PDLQESAVLK KILAYQRKLL NYFARNFYNM RMLALFVAFA INFILLFYKV TGNWVWEEHT
     HTHPHRVSDE TGEPLKPVSV RFVLEESSGY MEPMLRILAV LHTVISFFCI IGYYCLKVPL
     VIFKREKEVA RKLEFDGLYI TEQPSEDDIK GQWDRLVINT QSFPNNYWDK FVKRKVMDKY
     GEFYGHDRIS ELLGLDKAAL DFSDAHKKRK PRKDSSLAAV LNSIDVKYQI WKLGVVFTDN
     SFLYLAWYMT MSILGHYNNF FFAAHLLDIA MGFKTLRTIL SSVTHNGKQL VLTVGLLAVV
     VYLYTVVAFN FFRKFYNKSE DGELPDMKCD DMLTCYMFHM YVGVRAGGGI GDQIEDPAGD
     EYEIYRIIFD ITFFFFVIVI LLAIIQGLII DAFGELRDQQ EQVKEDMETK CFICGIGNEY
     FDTVPHGFET HTLQEHNLAN YLFFLMYLIN KDETEHTGQE SYVWKMYQER CWEFFPAGDC
     FRKQYEDQLN
//
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