ID M4AIX9_XIPMA Unreviewed; 937 AA.
AC M4AIX9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR005813};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000014423.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000014423.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000014423.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR005813, ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR005813}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|PIRNR:PIRNR005813,
CC ECO:0000256|RuleBase:RU003756}.
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DR AlphaFoldDB; M4AIX9; -.
DR STRING; 8083.ENSXMAP00000014423; -.
DR Ensembl; ENSXMAT00000014443.2; ENSXMAP00000014423.2; ENSXMAG00000014388.2.
DR eggNOG; KOG0219; Eukaryota.
DR GeneTree; ENSGT00550000074867; -.
DR HOGENOM; CLU_002472_10_0_1; -.
DR InParanoid; M4AIX9; -.
DR OMA; LVRFPQK; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0032301; C:MutSalpha complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03285; ABC_MSH2_euk; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR032642; Msh2_ATP-bd.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR005813};
KW DNA repair {ECO:0000256|PIRNR:PIRNR005813, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR005813};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR005813};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 744..760
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 853..878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 554..581
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 937 AA; 104309 MW; 20263E880D6845C6 CRC64;
MAVQPKQNQN LSLDSAAEHG FLNFIFSMPE KPDTTFRIFD RNDYYTVHGK DAIFAAKEVF
KTNGVIKYLG SGSRKLESVI LSKLNFEAFA KDLLLVKQYR VEVYRNQSKS SKEHDWRIEY
KASPGNLTQF EDILFGGGSG GEGCAGVVAV RFATGADGQR VVGVGYVDAA QRTMGVCEFP
DNEIFSNLES LLVQISPKEC LLAQGECSAE GNKLREVVQR GGVLVSDRKR AEFSSKDIVQ
DLNRLLRSKR GETMASNTLP ELDKQVAMSC LAAVVRFLEL LSDESNFNSF SLTTLGLGQY
MRLDNAAVRA LNLFQGSPDD TSGAHSLAGL LNKCRTPQGQ RLVNQWIKQP LMDKTKIEER
LDLVESFVCD SELRQTCQED LLRRFPDLHR LAKKFHRHTA TLQDCYRVYQ AVSHIPALIT
ALESYSGSYK VLLHAVFTSP LTDLQTDFIK YQEMIETTLD VNQIEHHEFL VKASFDPALS
ELREKMDALE KSMQAVLSSA ARELGLEAGK TVKLESNAIL GFYLRVTCKE EKSLRNNKKF
TTLDVQKNGV RFTNSKLSSL NEEYTRNREE YEEAQNAIVK EIINIASGYV DPLQTLSDVI
AQLDAVASFA VASVSAPVPY VRPQLLDDGR RRLELLQARH PCMETDADTA FIPNDISFVQ
GEKSFYIITG PNMGGKSTFI RQVGLIALMA QIGCFVPCEK AELSVIDSVL ARVGAGDSQV
KGVSTFMSEM LETAAILRSA TENSLIIIDE LGRGTSTYDG FGLAWAISEH ISSKINCFCL
FATHFHELTA LAAQQPAVHN LHVTALTTHN TLTMLYRVKP GVCDQSFGIH VAELACFPPS
VLAVAREKAE ELEEFQEPVG DDSKRDEEPE VKRRRTDKQV GEKLIQDFLE KVKALPVVTM
TEEEVKAELR RIKQDLVAKN NTYISEILAR CAPVKTA
//
