ID M4AMN4_XIPMA Unreviewed; 3889 AA.
AC M4AMN4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Dynein axonemal heavy chain 12 {ECO:0000313|Ensembl:ENSXMAP00000015728.2};
GN Name=DNAH12 {ECO:0000313|Ensembl:ENSXMAP00000015728.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000015728.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000015728.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000015728.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 8083.ENSXMAP00000015728; -.
DR Ensembl; ENSXMAT00000015751.2; ENSXMAP00000015728.2; ENSXMAG00000015666.2.
DR eggNOG; KOG3595; Eukaryota.
DR GeneTree; ENSGT00940000154280; -.
DR HOGENOM; CLU_000038_0_2_1; -.
DR InParanoid; M4AMN4; -.
DR OMA; CIEWQRY; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 616..1048
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1177..1503
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1670..1805
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2018..2115
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2176..2436
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2450..2796
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 2824..3046
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3288..3402
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3438..3576
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3584..3885
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 574..601
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2687..2742
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3889 AA; 444077 MW; D421FED91EFBCBA7 CRC64;
MATSSGISKA TLEGLPKLQV LPPIEKLKGA LEIFQKKKYF KIFKNIYCFY FVLHCLKMKY
RFMKHCVESR PFAPIQKEWL DSVVARIAPE LREYPKADKL LQELCTEATE EFRNVIVKHT
GKASYMGVQK YLHPLNSTQS SSELYRGFYL GVSERKLHIL HPVMQAILDI GYVSFTGMVL
LESCRCRSAA VECEKKESEI MNTWFPQIIQ LLTTEEIVGE LKEEQLNSFY NCASTLMSNQ
LKFLLQESVK RFVSFFDPSN QHCLPVFLMS LTFDDGKMDI YPTLKDLEDS VLEIINSIAS
SLQRVQTVQS WLAQTSSPCV DACVPDEILT WALVTVTNAV RKHLEEPDKH LKTYVKSYDW
LVNGTAQTQV DTFLKEEHTF EEFTEEVEEF HALSREITNL PSKVYFPMIH LECEELKQSL
CDKAKMFADI LLKTLVTKHR EQNLEICSEF EIIQEKSQEI PENIDAMAQM VDYMILTKTK
TLEDLNEKLQ EASTRLMYML DVHIMEPEDL ELNSTVFLWP KNILDAFVLN DVLQTAKQKG
EKELVEKREK LMIDLERLGN LSEQIVECSR LDMLQQYISK VRMIQQLLRD AEEAVDIVNK
EEVFYQWDLT SYPEVEAIKE HIEPYHKLFA FVLKWQNTES RWMDGSFLEL NGETMEIQVD
EFYREVFKLL KFFQQKQVKA AQEKEKISGM KKQKVSEEDV KRPDDPAVIL CSGAMTQIKT
FKEHVPVVSV LCNPGIRQRH WDSMSKIVDH DLTPNSGTTL RKVLKQNLTP YLTEFESISA
AASKEFSLEK AMQTMVQTWD GVAFNHQPYR ETGVSILTSL DDVQTMLDDQ IVKTQTMRGS
PFIKPFEKEI KQWEERLLNI QTIIDEWLKV QAQWLYLEPI FSSQDIMQQI PEEGRLFQAV
DRNWKEIMRH CVKDPMILPA TALPSLLEKL VNSNELLDKI MKGLNAYLEK KRLFFPRFFF
LSNDEMLEIL SETKDPLLVQ PHLKKCFEGI SKLDFLPNLD IQAMYSSEGE RVGLIQRIST
SEAKGAVEKW LIQVEDVMLR SIRDVIARSR LAYPATPRDQ WVTEWPGQVV ICTSQIFWTV
EVHEAIRKGV KGIKAYYEKL KDQLNDIIKL VRGKLSKQTR ITLGALVTID VHARDVVVDL
IEKGVSHETD FQWLAQLRYY WTNENVRVRI INCDVCYAYE YLGNSPRLVI TPLTDRCYRT
LIGAFYLNLG GAPEGPAGTG KTETTKDLAK ALAVQCVVFN CSDGLDYIAM GKFFKGLASS
GAWACFDEFN RIELEVLSVV AQQVLCIQRA IELKLEYFDF EGTTLKLNPN CFVSITMNPG
YAGRSELPDN LKVLFRTVAM MVPNYALIAE ISLYSYGFLN AKPLSVKIVM TYRLCSEQLS
SQFHYDYGMR AVKAVLVAAG NLKLKYPNEN EDILLLRSIK DVNEPKFLSH DIPLFNGITS
DLFPGISLPE ADYKLFLESA RECCEKHNVQ PTEVFLQKII QTYEMMIVRH GFMLVGEPFA
GKTKVLHVLA DTLTLMNEKG HEGEEKVIFR TLNPKSITMG QLFGQFDLVS HEWTDGIVAN
TFRDFALGDT PERKWVVFDG PIDTLWIESM NTVLDDNKKL CLMSGEIIQM SNQMSLIFEA
MDLSQASPAT VSRCGMVYME PSQLGWKPLV ISWMNTLPDP LKSQDHHDLL MDLFLWLFPP
SIVKLRKQCK EVVSTSNSNT AVALCRLFEM LIVEPLTAHP EDKNIRIWIM AAFSFSLVWS
VGGACDADSR EKFSQFVRAT LSGETQECPV PETVGKWECH MEEKGLVYDY FYEFKGRGKW
FHWNETIKSI YLGDKNTKVQ DIIVPTIDTV RYTYLMDLCI NHGIPPLFVG PTGTGKSVYV
KEKMMNNLDK DSFLPFFINF SARTIVETHH KRRKGVFGPP VGKKCVIFVD DMNMPALEQF
GAQPPVELLR QYMDHRNWYD LKDTTRITLI DIQFLCAMGP PGGGRNAVTP RFLRHFNIVS
INPFSDDTMV RIFSNIVAFY LKNNAFAPEC FTIGNQIVAA TMEVYKQAME NLLPTPAKSH
YTFNLRDFSR VIQGCLLLKK ESLENRHTMT RLFVHEVLRV YYDRLVDDKD RAWLYKLMNR
IVKDHFKESF EQVFDHLKKG SELEEDDMRN LLFGDYMEPE LEDDERLYAE VPSTEAFAVV
VEACLEEYNQ MHKNRMNLVI FRYVLEHLSR VSRVLKQPGG NALLAGVGGS GRQSITRLAT
SMAHMTLFQP EISKSYGMTE WREDLKMLLK NAGVKGQKMV FLLTDAQIKD EGFLEDVDSV
LNTGEVPNLF AVDEKQEIME AIRPVAQAGN KTLELNPLAL FAFFISRCRE NLHVVVAFSP
IGIAFRNRLR QFPSLINCCT IDWFQPWPEE ALEKVANCFL GSLEMTDNER IEVIPICKTF
HTTAKQLSQQ FLDELGRTNY VTPTSYLELI ATFYQLLTRR RDTVMKAKQR YTNGLDKLAF
AESQVAEMKK ELVELQPKLE VAKIENNKMM KVIEEESVEV EAISKVVRVD EEAATIKANE
AQALKNECES ELAEAVPALE AAVAALDTLK PADVTIVKSM KNPPSGVKLV MSAVCVMKDI
KPDKIADPAG TGKKVFDFWG PSKKLLGDMN FLRDLKEYDK DNIPIAVMQK IRSEYMTNPD
FDPSKVAKAS SAAEGLCKWI KAIEVYDRVA KVVAPKKQSL AEAQESLAIT IALLDQKRSE
LKEVEDRLAS LQKTFEEKTE EKAQLEYQVD LCAKKLERAE KLIGGLGGEK TRWSKAADDL
QNTYDNLTGD VLISAGVIAY LGAFTSGFRH NCTKTWTSLC QSKNIPSSDD FSLSKTLGDP
IKIRAWNIAG LPSDSFSIDN GVIVSNSRRW PLMIDPQGQA NRWVKNSEKE NNLSAIKLTD
SDYIRTLENC IQFGTPLLLE NVGEELDPSL EPLLLKQIFK QGAGVNCIRL GETVIEYSED
FRFYITTKLR NPHYLPELST KVSLLNFMIT PEGLEDQLLG IVVAKERPEL EEERNALILQ
SADNKRQLKE IEDKILETLQ SSEGNILEDE SAIQILDSAK IMSNEITKKQ LIAEKTEIKI
AESREGYRPI AKHSSILFFS IADLTNIDPM YQYSLSWFVN LYVNSIQDSN KSKILERRLQ
YLIDHFTFNL YCNICRSLFE KDKLLFSFLL CCNLLLAKGE LEHSEFMFLL TGGVGLKNTV
PNPDSSWLQE KCWDEICRAN ELHGLQEAFI NNPDDFKPIH DSKEPFNVPL PAPWCDQLST
LQKMIVIRCL RPDKMVPGMI KYVSSNLGKK FVQPPPFDLG KSYLDSNSTI PLVFVLSPGA
DPMASLLKFA NDKKMSGNKF QAISLGQGQG PIASKMISTA MEEGSWVCLQ NCHLAVSWMT
SLEKICENFS PATCHLDFRL WLTSYPSPKF PVTILQNGVK MTNEPPTGLR LNLLQSYLSD
PVSDPNFFNN CPKKELIWEK LLFGLCFFHA LVQERKKFGP LGWNIPYGFN ESDLRISIRQ
LQLFINEYEE VPLEAITYLT GECNYGGRVT DDWDRRLLLT TLADFYNKDI IETFRYPFSP
SGDYFAPPKS SYDDYVLFIK NLPFSQNPEV FGMHENVDIS KDLQQTKLLF DSLLLTQGGG
ENGGSSSGGD HTLFDIANNI LTQLPNNFDT EAALLKFPVR YEESMNTVLV QEMERYNTLY
STIRVSLQNL LKAIKGLVVM DADLEAVAGS LIVGKVPEKW ANRSYPSLKP LGSYINDFLS
RLKFLQAWYE TEKPCVFWMS GFFFTQAFLT GAMQNYARKY HIPIDLLGFD FEVLSFDTSE
TAPADGVYVH GLFVDGARWD RDSGVLAEQY PKILFDSMPI IWIQPTEKGS TTPPDQLYVC
PLYKTSERKG TLSTTGHSTN FVISMMLPTS KRPQHWIKRG VAMLCQLDD
//
