ID M4APJ3_XIPMA Unreviewed; 691 AA.
AC M4APJ3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=U4/U6 small nuclear ribonucleoprotein Prp3 {ECO:0000256|ARBA:ARBA00016514};
DE AltName: Full=Pre-mRNA-splicing factor 3 {ECO:0000256|ARBA:ARBA00032955};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000016388.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000016388.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000016388.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in pre-mRNA splicing as component of the U4/U6-
CC U5 tri-snRNP complex that is involved in spliceosome assembly, and as
CC component of the precatalytic spliceosome (spliceosome B complex).
CC {ECO:0000256|ARBA:ARBA00035603}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; M4APJ3; -.
DR STRING; 8083.ENSXMAP00000016388; -.
DR Ensembl; ENSXMAT00000016412.2; ENSXMAP00000016388.1; ENSXMAG00000016347.2.
DR eggNOG; KOG2769; Eukaryota.
DR GeneTree; ENSGT00390000011497; -.
DR HOGENOM; CLU_015750_3_0_1; -.
DR InParanoid; M4APJ3; -.
DR OMA; KNHEMRN; -.
DR OrthoDB; 5489218at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IEA:InterPro.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR Gene3D; 1.20.1390.10; PWI domain; 1.
DR InterPro; IPR013881; Pre-mRNA_splic_Prp3_dom.
DR InterPro; IPR027104; Prp3.
DR InterPro; IPR010541; Prp3_C.
DR InterPro; IPR002483; PWI_dom.
DR PANTHER; PTHR14212; U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED; 1.
DR PANTHER; PTHR14212:SF0; U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3; 1.
DR Pfam; PF08572; PRP3; 1.
DR Pfam; PF06544; Prp3_C; 1.
DR Pfam; PF01480; PWI; 1.
DR SMART; SM00311; PWI; 1.
DR PROSITE; PS51025; PWI; 1.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 1..87
FT /note="PWI"
FT /evidence="ECO:0000259|PROSITE:PS51025"
FT REGION 96..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 691 AA; 77783 MW; ECCD26978C24E849 CRC64;
MSLPKREVEE LRPWVERTVK KVLGFSEPTV VTAALHCVGK GLDKKKTTDQ LRPILDDSAG
GFVERLFEAL EESRNSRGGK GASEKHRKRE LKEVFGEESD TGAVQVAPDA GDGTTAKRKR
VPRFQEVEEP EVIPGPPSES PGMLTKMQIK QMMEAATKQI EERKKQLSFT SPATGDGSRL
LGAAAGGASS IAPSQAASFM NDAIEKARKA AELQARIQSQ LAQKPGILNT FVNTGPPNLV
ALANLHAMGI APPKVDIKEV NKPTPLILDD KGRTVDATGK EIELTHRMPT LKANIRAVKR
EQFRQQLKEK PGDDIESTSY FDQRVLITPA QRTRRGFKFH EPGRFEKIAQ RVRTKAQLER
LQNEIAQAAK KTGIQASTKL ALIAPKKEIG EGDVPNIEWW DSYILSTYMP INPESKFEEF
DLFGVTNLVE HPAQISPPVD TDKPVTLGVY LTKREQKKLR RQTRREAQKE VQEKVRLGLM
PPPEPKVRIS NLMRVLGTEA VQDPTKVEAH VRAQMAKRQK AHEEANAARK LTAEQRKEKK
VKKLKEDLTN GVHATVYRIR NLQNPAKKFK VEANANQLYL TGTVVLHRDV NIVVVEGGPK
AQKKFKRLMM HRIKWEEHNS KRDDPDGDDD TRRNNKCWLI WEGTAKERSF GEMKFKQCPT
ENMAREHFKK HGTEHYWDLA LSQSVLEGSD D
//
