ID M4APW2_XIPMA Unreviewed; 934 AA.
AC M4APW2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN Name=ANO1 {ECO:0000313|Ensembl:ENSXMAP00000016507.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000016507.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000016507.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000016507.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR AlphaFoldDB; M4APW2; -.
DR STRING; 8083.ENSXMAP00000016507; -.
DR Ensembl; ENSXMAT00000016531.2; ENSXMAP00000016507.2; ENSXMAG00000016443.2.
DR eggNOG; KOG2514; Eukaryota.
DR GeneTree; ENSGT00940000157182; -.
DR HOGENOM; CLU_006685_1_2_1; -.
DR InParanoid; M4APW2; -.
DR OMA; QSEQGAF; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF13; ANOCTAMIN-1; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 314..338
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 391..407
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 472..494
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 514..538
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 558..579
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 683..706
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 740..763
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 82..266
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 303..877
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT REGION 903..934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 934 AA; 108161 MW; 865E584F9862BDAA CRC64;
MDSEPRPQLQ VFSKKYFNVC DWKCDEMQKG SIDVKTLKTH SVIWTDALSW FPSFIACNSL
LRQAPVSHRD AGENINCYHG LFFQDGQRRV DYILTYPVRK SGGGRSSRQS DHSLTENFAS
RTLGQSKQVQ GASTVADVEM GCLGETLNSQ EDHKTFRREE FEKNLKEMGL ELEKDEEAMI
PGLGFVKIHA PWNVLCREAE LMKLKMPTKK VYEVKQSSNF MKKISSLVNK VLEPLHPNVE
DHHSKNIKHL SHSFSREKQH LMRKKPDKNV TITQLIIVIS QQLLYEEWAN YSVFYKYQPI
GLVRKYFGEK IGLYFAWLGL YTQMLIPASL VGVIVFLYGC ATVDDNIPSM EICDPKNNIT
MCPLCDRVCS YWKLSTACGT ARAGHLFDNP ATVFFSIFMA LWAAMFMEHW KRRQMRLNYE
WDLTGFEDEE DHPRAEYEFR VMQKSLKKEK KSPQKVEKLT CRDRLPAYMT NIVMMLLMIG
VTFAIVFGVI LYRISTKAAL YMSSSPTTRS HVQLTVKTTA AIINLVVILI LDEVYGAVAR
WLTVLEAPKT EKNFEERLIF KTFILKFVNA FTPIIYIAFF RGRLVGRPGR YLYVFESYRM
EECSDGSCLM ELCIQLSITM LGKQLIQNNL FEIGIPKLKK LIRYIQSEQG AFQEEERQKK
LRRYETDHFL EPFGGLTPEY MEMIIQFGFV TLFVASFPLA PLFALLNNII EIRLDAKKFV
TELRRPVAAR AKDIGIWYDI LRGVAKVAVV INAFVISFTS DFIPRMVYQY MYSPDGSLHG
FVNHTLSYFN VSHFEHGKET MDPMPYGYPI EVCRYKDYRE PPWSLTPYEI SKEFWAVLAV
RLAFVIVFQN VVMLMNDIVD WLIPDIPKDI SQQIHKEKIL LVELFMRQEQ GMINILERGG
SSSMKETYRR SNNNNNSTTA PLFSKEQPNG TKQF
//
