ID M4AQG7_XIPMA Unreviewed; 1042 AA.
AC M4AQG7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Solute carrier family 12 member 1 {ECO:0000313|Ensembl:ENSXMAP00000016712.1};
GN Name=SLC12A1 {ECO:0000313|Ensembl:ENSXMAP00000016712.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000016712.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000016712.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000016712.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) +
CC K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR RefSeq; XP_005814814.1; XM_005814757.1.
DR AlphaFoldDB; M4AQG7; -.
DR STRING; 8083.ENSXMAP00000016712; -.
DR Ensembl; ENSXMAT00000016736.2; ENSXMAP00000016712.1; ENSXMAG00000016567.2.
DR GeneID; 102220049; -.
DR KEGG; xma:102220049; -.
DR CTD; 6557; -.
DR eggNOG; KOG2083; Eukaryota.
DR GeneTree; ENSGT00940000158030; -.
DR HOGENOM; CLU_001883_0_0_1; -.
DR InParanoid; M4AQG7; -.
DR OMA; FRIKFAE; -.
DR OrthoDB; 5490251at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF93; SOLUTE CARRIER FAMILY 12 MEMBER 1; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 1.
DR PRINTS; PR01207; NAKCLTRNSPRT.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 132..153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 277..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 443..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 496..515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 521..542
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 554..578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..105
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 131..636
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 645..1042
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 91..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1042 AA; 114512 MW; 945C7348AEA02476 CRC64;
MERLKANGGG HVNSAFDSNL GDPPIYEETE FSNNEHRTVR PSVMSAFGHD TLDRVPNIDF
YRNAGSVSGH RAVRPSLQEL HDVFQKNGTI SVPETVTDDG EGSEGTPSDD LESAVPTDVD
KGAVKFGWIR GVLVRCMLNI WGVMLFIRLS WVFGQAGWGL GIVVIALSCV VTTITGLSMS
AICTNGVVRG GGAYYLISRS LGPEFGGSIG LIFAFANAVA VAMYVVGFAE TVVDLLKEYA
DLMVDEMNDI RIIGCITVVL LLGISVAGME WEAKAQIVLL VILLVAIVNM FVGTAIPATE
DKKSKGFFGY NTKLFMENFT PDFRDGETFF SVFAIFFPAA TGILAGANIS GDLRDAQAAI
PKGTLLAIFI TGITYLGVAL CVAGTVVRDA TGNMTDLVTP GVPCNGSSVI ACELGYNFSS
CETEPCKFGL MNNFQVMTMV SGFGPLITAG TFSATLSSAL ASLVSAPKVF QALCKDNIYK
ALHFFAKGHG KNNEPIRGYV LTFVISVAFI LIGDLNTIAP IISNFFLASY ALINFSCFHA
SYAKSPGWRP AYKYYNMWLS LVGALLCCVV MFVINWWAAL LTYGIEILLY IYVTVKKPDV
NWGSSTQAVS FVSAVSNALS LSGVEDHVKN FRPQILVLTG SARARPALLD LAHSFTKNYG
LCLSCDVLVG PRSAIMPEMN NGMEKNQMWL NKNKRKAFFA AVACDNFREG AETLLQASGL
GRMKPNTLMI GFKRNWRTAE TKAVQSYVGI LHDAFDFEYG TVVLRMNQGL DVSHLVEEEE
EMLKAAKEQQ ALDNEMLPNG GKTKGLFRKS RHSSQQVLTT RVSVCGPPPP QIAKMNEKLV
EASGQFKKKQ PKGTIDVWWL FDDGGLTLLL PYILTTRKKW KDCKLRIFIA GQPGRTEIDK
EEMRSLLHKF RIKSSDITVI DDIHIKPRND NIKKLEDMIE PYRLREGSKG RDQAAGIQEY
PWKITDAELS SFEEKTHLQV RLNELLQEHS KSANLIVLSL PIARKGSISD FLYMAWLDIL
TKDLPPTLLI RGNHKSVLTF YS
//
