ID M4AQU5_XIPMA Unreviewed; 1021 AA.
AC M4AQU5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=EPH receptor A10 {ECO:0000313|Ensembl:ENSXMAP00000016840.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000016840.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000016840.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000016840.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; M4AQU5; -.
DR STRING; 8083.ENSXMAP00000016840; -.
DR Ensembl; ENSXMAT00000016864.2; ENSXMAP00000016840.2; ENSXMAG00000016808.2.
DR eggNOG; KOG0196; Eukaryota.
DR GeneTree; ENSGT00940000164552; -.
DR HOGENOM; CLU_000288_7_40_1; -.
DR InParanoid; M4AQU5; -.
DR OMA; FGCLQLP; -.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005003; F:ephrin receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.40.1770; ephrin a2 ectodomain; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR027936; Eph_TM.
DR InterPro; IPR001090; Ephrin_rcpt_lig-bd_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR InterPro; IPR016257; Tyr_kinase_ephrin_rcpt.
DR InterPro; IPR001426; Tyr_kinase_rcpt_V_CS.
DR PANTHER; PTHR46877; EPH RECEPTOR A5; 1.
DR PANTHER; PTHR46877:SF16; EPHRIN TYPE-A RECEPTOR 10; 1.
DR Pfam; PF14575; EphA2_TM; 1.
DR Pfam; PF01404; Ephrin_lbd; 1.
DR Pfam; PF07699; Ephrin_rec_like; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF00536; SAM_1; 1.
DR PIRSF; PIRSF000666; TyrPK_ephrin_receptor; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00615; EPH_lbd; 1.
DR SMART; SM01411; Ephrin_rec_like; 1.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS51550; EPH_LBD; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00791; RECEPTOR_TYR_KIN_V_2; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR000666-3};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1021
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017387908"
FT TRANSMEM 577..601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..205
FT /note="Eph LBD"
FT /evidence="ECO:0000259|PROSITE:PS51550"
FT DOMAIN 326..430
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 435..531
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 655..911
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 946..1010
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 523..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 68..187
FT /evidence="ECO:0000256|PIRSR:PIRSR000666-3"
FT DISULFID 104..114
FT /evidence="ECO:0000256|PIRSR:PIRSR000666-3"
SQ SEQUENCE 1021 AA; 112495 MW; D4C29FD16C08FF03 CRC64;
MDACRTLAAL LWVLLLRRVQ VCQAEEVVLL NSKETQAELG WTSFPPNGWE EISGVDEKYK
PIRTYQVCNV MEPTQQNNWL QTGWVARRGG QRIFVELQFT LRDCNSIPGV AGTCKETFNL
LYVESDRDLG AVTREDRYSK IDTIAADESF TQGDLGERKM KLNTEVREIG HLNRKGFHLA
FQDVGACVAL VAVRVYYKRC LATVQNLAVF PDTVAEAAFA TLVEVRGGCV NNSEVDSDSP
PKMHCSAEGE WLVPIGKCSC SAGYEEGHSS CEACPPGSYK MSSRQQECFP CPANSVAEEE
GSVVCVCEED HFRTPLDSPS TPCTRPPSPP RSLRFSLRQS SLVLDWAPPS DSGGRVDLTY
SVGCRRCGPA RCEPCGPGVG FVPQQVGLTE RTVTVVNLLP NTNYTFSVEA LNGVSDLLPS
KSFYTQVNVS TSLPPPSLIS ELRAEKVEEK SVTLVWREPP NPNSSRTEYE VKYYEKDQKD
QSYSTVKTAA TRIIVNNLKP GTTYVFLIRP FLTPAPSSSL SSSALSSTSS TSASSSSSSS
SSSSSTPPPI DYGAFSAPLE LQTLGELALA SSEQNPVVII VIVSVAALIM LLSMGAGLLL
WRRQCGYSKA SQEGDEELYF QFKIPTRRTY IDPETCEDLL QAVHAFAKEL DNQSIKIERI
VHTGDFGEVC RGCLKLPSKR ELPVAIRTLR AGCSDKQRRS FLSEAGILGQ FDHANIIRLE
GVITTGNTMM IVEESMTNGA MDSFLRKHEG QLSVMQLMDM LTGVASGMKY LTEMGFVHKR
LAAHKVLVNS NLTCKVSGFR PLQEEKIDSI YTTLHGGKSV VLWTAPEAIQ YRRFSSASDV
WSFGIVMWEV MSYGERPYWD MGTQDVIKAI EDGFRLPAPV NCPPHLHQLM LDCWQKERAE
RPGFSQIHSA LSKSVRSPDG IGSSTLARRT LSSSISLAER PLPSFPSFSS VGEWLDAVDM
SRYKDNFTAA GYCYLESVAR MTVQDVLSLG VTSLDHQKLI LAAIQTLRAQ VIQMHGRGVQ
V
//
