ID M4AS82_XIPMA Unreviewed; 1794 AA.
AC M4AS82;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Plexin D1 {ECO:0000313|Ensembl:ENSXMAP00000017327.2};
GN Name=PLXND1 {ECO:0000313|Ensembl:ENSXMAP00000017327.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000017327.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000017327.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000017327.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR Ensembl; ENSXMAT00000017351.2; ENSXMAP00000017327.2; ENSXMAG00000017238.2.
DR eggNOG; KOG3610; Eukaryota.
DR GeneTree; ENSGT01020000230394; -.
DR HOGENOM; CLU_001436_1_1_1; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR CDD; cd12788; RasGAP_plexin_D1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF7; PLEXIN-D1; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 3.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..1794
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017201480"
FT TRANSMEM 1122..1145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1157..1182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..516
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
SQ SEQUENCE 1794 AA; 201095 MW; EDD8E56DE0388D21 CRC64;
LARLRSEGRM PPSMEIAVLL LGVLTLETRR SASALHIQQA FASPNLTNNF VVDPVSRRVY
LATVNTVYQL NGTLTVEVEK RTGPVEDNLL CHAPQLPQAP CEHPKSLTDN YNKLLELDRE
QGVVVMCGSV YQGFCELRRM GNISEIAVEF PPRGEKTVFP SMLNIAANHP NASTVGLIFK
SHGGNTRLLV GATYTGAGTQ FFPKNHSKED LRFENTPEIA IRSLNIKDLS RLFTYDINPS
EDNVFKIKQE VKTKNKLNFV HAFIQKTYSY IAFNNDATMG HKENQPNSIL ARICLDSDIP
RKSTGSESKK LTESYIQMPL QCGANGNIHN RLVSVYSAEV HGGSGGVPEP YLFGAFSKAD
RKSALCAFKF GDIEAEIRQG RWNCSNSPSS DVQVLDSVIQ GSGAVCIQKG NIVLQPEQLD
CGAAHLQHPL ALRRPLRAIP LFEFQDLSSV SVDNVHNHTV VFLGTSNGCL HKVRNFQLST
MKLPAGEAVH HIMTFDPNDG NFLYVMTSHH MLRVKVAECD QWKSCTDCLG ARDAYCGWCT
LENRCTIQNE CARGLLPRSW ITLGEGPKQC PSITLTPPEI SISSEIEAVG ILINGSIPDL
IGSKVECEYK PGVSTAATVY GLAQIQTCPL LSPENYQPIP FGTDHLTVSV AIKVNGTSVV
SGSFIIYDCE RTGQIHPKTA CMSCLSTRWK CYWDQEHHQC LSSKDESKPN LLEVSNSPSN
LSTRQIPGGV HDISILQVYN CGVGSSDCSQ CWGREDQGHL CGWCENSCRP RDDCQPDRDV
CPAPEIHKIS PLRGPVEGGT LLTVQGRNLG RRPAGVNIFI GDVPCDLLPE RYTVSVELVC
HTGRSLHDRT DSVRVDVDQS GTGTSKESFA YLVPNVKSIY PEKGSRVGGT RVTIRGKHLD
IGSQVRVKVN GTQECTITEK TDQTIKCIMP PALEADAELV TVCVEFEDHP CEEANISTMY
TYEQNPTISS IHPTKSFLSG GRTITVKGHG FDLVQSVTMN VLEIGQTNCS VLSSSTITCL
SPESSQSQET SVQFVLNGVP YTGDSPSSSD DRPGEPHKEH FQLGYVEDPQ FFTTNKDKQI
KHHSGEPLTL IINVSNEADT ECASLLCSGV IYLILTRFYH NYISFVFPII CSNSGLIWCI
LMGNFRHMIT KVQLGGSELA IVVSIVVCCV LLLLCTVALV VYCTKSRRAE RYWQKTLLQM
EEMESQIREE IRKGFAELQT DMTDLTKELN RSQGIPFLEY KQFVTRTFFP KMCSDYENSL
VQPTYVNDSL GPRVLPETHP LLQDWQANDT TRPNVEEGIT LFSTLLNNKH FLITFVHALE
QQKDFAVRDR CSLASLLTIA LHGKLEYYTS IMKDLLVDLI DASASKNPKL MLRRTESVVE
KMLTNWMSIC MYSYLKETVG EPFFLLLCAI KQQINKGSID VLTGKARYTL NEEWLLRENI
ETKPQNINVS FQGCGMDSLS VRVMNTDTIC QVKEKIIEAF YKNLPFSQWP RAEDVDLEWF
DSGSNSKLLQ DLDNSSVMED GRKKLNTVFH YQIPEGASLA MSMKDKKENT LERETKKSHR
HSHRKKVLPE IYLTRLLSTK GTLQKFLDDL FRAILSIPPD RPPLAIKYFF DFLEEQADKR
GITDPDTLHI WKTNSLPLRF WVNILKNPQF VFDIDKTDHM DACLSVIAQV FIDACSISDL
QLGKDSPTNK LLYAKEIPEY KKNVQCYYKQ IQEMPPLSEQ EMNAHLAEES RKYRNEFNTN
LALTEIYKYA KRYRNQVVNA LEANPTARRT QLHHKLEQVI ALMEDNIYEC CSEA
//
