ID M4AT93_XIPMA Unreviewed; 1455 AA.
AC M4AT93;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRK {ECO:0000313|Ensembl:ENSXMAP00000017688.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000017688.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000017688.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000017688.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR STRING; 8083.ENSXMAP00000017688; -.
DR Ensembl; ENSXMAT00000017713.2; ENSXMAP00000017688.2; ENSXMAG00000017572.2.
DR eggNOG; KOG4228; Eukaryota.
DR GeneTree; ENSGT00940000156249; -.
DR HOGENOM; CLU_001645_0_0_1; -.
DR InParanoid; M4AT93; -.
DR OMA; RIATKXK; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR CDD; cd06263; MAM; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF11; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00409; IG; 1.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1455
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017223854"
FT TRANSMEM 746..767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..188
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 190..275
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 288..383
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 485..589
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 903..1157
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1077..1148
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1189..1451
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1365..1442
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1455 AA; 163717 MW; A8D9D3FF67B0DE6A CRC64;
MDTLFSVFLG VVILCSRVGS VSAQLPTGSC TFDEGFSQCD YQQDPYDDFD WTHINTQEVP
YVSPDLPQGS YMFVDVSQYD VGEKARFQLP VMKENDTHCI DFNYLLTSPD GSSPGTLNIL
VKVNKGPLAN PIWNVTSYTG KGWLKAELAV STFWPNEYQV IFEAEVSDSK AGYIAIDDIQ
VLSYPCDKSP HFLRLGDVEV NAGQNATFQC IATGRDTSSN KLWLQRRNGE DIPVAQTKNI
NHRRFAASFH LKEVTNQDQD LYRCVTQSER GSGVSNFAGL IVREPPHPIA PPQLLGVGPT
YLLIQLNANS IFGDGPIILK EVEYRMTSGT WTETHAVNSP NYKLWHLDPD TEYEIRVLLT
RPGEGGTGKS GPPLITRTKC AEPMRTPKRL KIAETRARLI AVDWESLGYN ITRCHTFNVT
ICYHYMTADN HSKADCLDMD PKAPRHLVGS LPPYTNVSLK MILTNPEGRK ESDETIIQTD
EDVPGPVPSQ SLRATPSEET IILYWKEPAE PNGVITQYEI NYSGVRSFDP SVPLQRPGLM
VSLPSNATHY TFAQLHPGVT YQLSIRASTS KGFGPASTLN VTTNISAPTI DEYDVSEAFL
NETATTITVL LKPAQAKGAP ISAYQIVVEE VNPQRSRRQA SSDCYEVPVS YHSASSGGSP
YYYAAQLSPS NLPEPLPFTV GDNKTYQGFW NPPLAPRKNY NIYLQAVSST ERETKTQCLR
LAAKRATEEP EVIPDPAKQT DRVVKIAGIS AGVLVLILLV LVAILLLKKR RTYYSYSYYL
KLAKKRKDAI GTTRQEMTHM VNAMDRSYAD QSTLHGEDPM AVTFMDSHNY NNRLPNDPLV
PTAVLDENHS ASAAENSRLL DVPRYHCEGT ESPYQTGQLH PAIRVADLLQ HINLMKTSDS
YGFKEEYESF FEGQSATWDV AKKEQNRTKN RYGNIIAYDH SRVILQPIED DPSSDYINAN
YIDGYQRPSH YIATQGPVHE TVYDFWRMVW QEQSACIVMV TNLVEVGRVK CYKYWPDDAE
VYGDFKVTFV EVEPLAEYVV RTFTLERRGF NEVREVKQFH FTGWPDHGVP YHATGLLSFI
RRVKMSNPPS AGPIVVHCSA GAGRTGCFIV IDIMLDMAER EGVVDIYNCV KALRSRRINM
VQTEEQYIFI HDAILEACLC GETAIPVCEF KAAYYELIRI DSQTNSSHLK DEFQTLNSVT
PQPQPEDCSI ALLPRNQDKN RFMDGLPPDR CLPFLITIDG ESSNYINAAL MDSYRQPAAF
IVTQHPLPST VKDFWRLVYD YGCTSLVMLN EIDLAQGCPQ YWPEEGMLRY GPVQVECMSC
SMDCDIISRL FRVCNLTRPQ EGYLMVRQFQ YLGWAGHRDV PASKRSFLKL ILQVDQWQRE
GEEGEGRTIV HCLNGGGRSG VFCASSIVCE MAKRQNVVDV FHAVKTLRNS KPNMVDTPEQ
YRFCYDLALE FIESS
//
