ID M4ATU6_XIPMA Unreviewed; 833 AA.
AC M4ATU6;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Eosinophil peroxidase-like {ECO:0000313|Ensembl:ENSXMAP00000017891.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000017891.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000017891.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000017891.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; M4ATU6; -.
DR STRING; 8083.ENSXMAP00000017891; -.
DR Ensembl; ENSXMAT00000017917.2; ENSXMAP00000017891.2; ENSXMAG00000017815.2.
DR eggNOG; KOG2408; Eukaryota.
DR GeneTree; ENSGT00940000156009; -.
DR HOGENOM; CLU_006087_1_1_1; -.
DR InParanoid; M4ATU6; -.
DR OMA; NSCMPFI; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR Gene3D; 1.20.5.320; 6-Phosphogluconate Dehydrogenase, domain 3; 1.
DR Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR InterPro; IPR019791; Haem_peroxidase_animal.
DR InterPro; IPR010255; Haem_peroxidase_sf.
DR InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR PANTHER; PTHR11475:SF63; EOSINOPHIL PEROXIDASE; 1.
DR PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR Pfam; PF03098; An_peroxidase; 1.
DR PRINTS; PR00457; ANPEROXIDASE.
DR SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR PROSITE; PS50292; PEROXIDASE_3; 1.
PE 4: Predicted;
KW Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..833
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017282598"
FT REGION 724..771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 811..833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..768
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 489
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ SEQUENCE 833 AA; 92406 MW; 4178C943D4464AF3 CRC64;
MNKFLCLLAV GLTLALQCQV DAKRHLSQSF IEKCVNKAKT SVDEAYTYSR QVSLDRVKRN
AASPADILRI LKQPNGPSRE AVRAADYMAN TLHVINHYLS KRHKRSINAT DLISKDDLGV
IARLTGCAAQ VRNIHCQDLP NLNTYRTASS ICNNLKNPRW GASNIPFLRW LPSEYEDGIN
SPKGWTHDLR VNNQLLPFVR EVSNRILAIN SSEVNSDPLY THLVTIFGQW TDHDITFTPQ
SPSIRSFNDG IDCEKTCGNT EPCFPIEFPS NEPRIRDHSE KCMPFSRSAP ACGSGNTGYI
FGSSTVRQQI NTLTAFIDVG QVYGSDDSKA RNLRNLTTDR GLLRVNNNYT DNGRDLLPFT
TMGANMCATR RRMTNDNSAE EVLCFFAGDD RSNENIGLAS LHTLMMREHN RLVRALAQLN
PKWDGERLYQ EARKIMGGYM QVITYRDYLL HIVGPEAVSK KLSTYPGYNE TIDPSIANVF
ATAAYRFAHL MVQPFIFRLD ENYQDHPNYP TNLLHRTMFA PWRIVFEGGL DPILRGLIGR
PAKLNTQDRM LTEELRDKLF KFSVNLALDL GSLNMQRGRD HGLPGYNKWR KFCGLSQPTT
LSELAEVLNN TVLAQKLLDL YGTPDNIDPW LGGVAEPFVR GGRVGPLFAC LISTQFQNIR
EGDRFWWENK GVFTDAQKLA IRDTSLARII CDNTGITEVP EKPFQYRPRG SGYTQCDAIP
AFDLSPWKDG AEGPEKPQPP TGQPGPPGPP GPPGPIGLPG PPGPPGPSGA AAHVAFSVRL
GSNVPKAGTP LPSMMSSTMD RTAMTPRLAF SPVSTQASMS LSSTAPSMTV QAA
//
