ID M4ATX9_XIPMA Unreviewed; 1069 AA.
AC M4ATX9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=NBR1 autophagy cargo receptor {ECO:0000313|Ensembl:ENSXMAP00000017924.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000017924.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000017924.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000017924.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005794782.1; XM_005794725.2.
DR AlphaFoldDB; M4ATX9; -.
DR STRING; 8083.ENSXMAP00000017924; -.
DR Ensembl; ENSXMAT00000017950.2; ENSXMAP00000017924.2; ENSXMAG00000017876.2.
DR GeneID; 102236463; -.
DR KEGG; xma:102236463; -.
DR CTD; 337168; -.
DR eggNOG; KOG4351; Eukaryota.
DR eggNOG; KOG4582; Eukaryota.
DR GeneTree; ENSGT00390000016335; -.
DR HOGENOM; CLU_014175_0_0_1; -.
DR InParanoid; M4ATX9; -.
DR OMA; WETVEAW; -.
DR OrthoDB; 5399396at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR CDD; cd14947; NBR1_like; 1.
DR CDD; cd14319; UBA_NBR1; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR032350; N_BRCA1_central.
DR InterPro; IPR000270; PB1_dom.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR20930:SF4; NEXT TO BRCA1 GENE 1 PROTEIN ISOFORM X1; 1.
DR PANTHER; PTHR20930; OVARIAN CARCINOMA ANTIGEN CA125-RELATED; 1.
DR Pfam; PF16158; N_BRCA1_IG; 1.
DR Pfam; PF00564; PB1; 1.
DR SMART; SM00666; PB1; 1.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS51745; PB1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 4..85
FT /note="PB1"
FT /evidence="ECO:0000259|PROSITE:PS51745"
FT REGION 105..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 654..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 758..783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 805..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 278..312
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 130..144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..519
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 758..774
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 805..827
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1069 AA; 117739 MW; 2DA8496DC18B59C7 CRC64;
MGLPVTIKVN FRGNVKRFLA QDVDKLEWES VEAWIKASFG INHFQVKYFD EDNEEICINS
QDEYEEAIKS AEKQGNQLHM NVYKMKGQAC GGPLKAEVKE LKGDLRPAPP YPSRVKAVDK
GTQITPERES GAVKENKGNK PDDDPPPMWF RSYMEKFKDE VVKEVVERMC NDFSGQCCTH
KSSDGLQEDI GVIEGPIGPR PGPSTSNGSL GYTPNCSTCN KLTSEGAYKC SVCPSCILCE
MCRHSHDPSH SLVRTKTPLS IPEHGMSGEF RFPRRGDRTV RKAERQRLKA ERRQLKAEVK
EIKKKLRLEK RGMQWSGPCT SDRASLANMA STSTQFPALP PPAASESASG PATDPGHIPA
PVPDPQASSP EGPGVSHTSL VPTMAALFLD ENLPDNTRLE PGTKFIKYWK MKNSGTISWT
SETKLVFMWG NLGLASEERR EVPVPLLLPG QVGVVSVAFV APVMEGMYTS HWRLAHCGCQ
FGPRVWCSIV VDSGSSRNGL GHQSKRLKEE VKPAEKEVTP KESGSAFTAD LPQEDFYFPS
VDLLTAQDLL SFELLDINIV QELEKVPNNT PVALTPCISP LPNDSSLLER TMTSQTKDES
EITGVRKLFG VKLRPKDVSE PVAQDEEKEE EISGAQFLCE TVIRSLTLEE APDHRPLRRP
KHSSLKPQVV TRGPGFGFER GVGVEEKQKV KVKQEEINAD RIQSLAPPVN TVFNQLTQGE
DDSRPDPELG GENVNLNISS HQDNEDKEVL HAMQNMKEKN CEKEEGRTRE DWDEVSSQTS
SVSSNDDYII VLPDCFDTSR PLGESMYSSA MSQPDTAAAA TAASSTDPDQ EQEKDEPCNF
EPCREAPLME RKEEETIAVE ESLGNTWPLH VSPIHSSVNQ MLCASQTLDA VTLTPEVVPP
PVVPQPLHPT PVIYSPRSEA LYLAGDPSPP ACEPYEPQQP RVHLNVSSGL SRSAGSACSA
FEAYNPRAGK ALQPRGQGGI TEGLVKGALS VAASAYKALF TGPNCSIQRG IDPVRQDPSM
MAVLLEMGFK DQRLNQQLLR KHGYNLLHTV NELVQMAEES QNEAADPPQ
//
