ID M4AUX1_XIPMA Unreviewed; 1653 AA.
AC M4AUX1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=IQ motif containing GTPase activating protein 1 {ECO:0000313|Ensembl:ENSXMAP00000018266.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000018266.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000018266.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000018266.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005808152.1; XM_005808095.2.
DR STRING; 8083.ENSXMAP00000018266; -.
DR Ensembl; ENSXMAT00000018293.2; ENSXMAP00000018266.1; ENSXMAG00000018181.2.
DR GeneID; 102219414; -.
DR KEGG; xma:102219414; -.
DR CTD; 8826; -.
DR eggNOG; KOG2128; Eukaryota.
DR GeneTree; ENSGT00950000183076; -.
DR HOGENOM; CLU_000972_2_1_1; -.
DR InParanoid; M4AUX1; -.
DR OMA; KGVLVHW; -.
DR OrthoDB; 12619at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR CDD; cd21274; CH_IQGAP1; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000593; RasGAP_C.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001202; WW_dom.
DR PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR PANTHER; PTHR14149:SF15; RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP1; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF03836; RasGAP_C; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF143885; RGC domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 42..157
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 676..709
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 1001..1234
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT COILED 166..193
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1653 AA; 187657 MW; C44C3DA540CEDF07 CRC64;
MSTSDDVDGQ RPRYGSVLDG VERLTAEEMD EQRQQNMAYE YLCHLEEAKR WMEACLDEEL
PPTTELEEGL RNGVYLAKLG NFFAPQTVSL KKIYDREQTR YKATGLHFRH TDNVIQWLNA
MAEKGLPKIF YPETTDIYDR KNMPRCVYCI HALSLYLFKL GLAPQIQDLY GKVAFTEEEI
NNMKNELAKY GIQMPAFSKI GGILASELSV DEAALHAAVI AINEAIDQGV PEGTLAAMQN
PNAVLLNLDP DSAQKYHDTL YQAKGEKVAS SRKRQLENTE AERDIYDELL TQAEIQGNIN
MVNVSNALSA AEQALVGGDE DKLYEALKAV GVQNLQPENK GWYLKQLQGE RENKEQVSPG
QPLTKDELQS GVDVANEVAA GYLKMLKAVE RINGAIRAGV PEKTVEELMN PDAQLPEVHP
GAADLYQKEL ACLQQQSAEG CLAHPELLVA VEMLSAVVLM NEALEVGDRA ALWRQLASSV
TGLSNVEDEY AQRYMDELMR LKAAAKEEGS KYLTWNDIQA CIDQVNLAVQ EEHERIAAIG
QINEALDEGD PMKTLDMLQN PSAKLTDVDP SIAQHYHDKL LEARREKAHE TQDPSAVLWL
DEIQDAILKA NQDTKEALLF SQSIQAINEA VDTGDSARTL AALRSPGAGL YGVTAECAPT
YQDDLAKIKE EKKNEGDNGS EWVKHWVKGG HNYYYNLQTK EGTWVEPEAF EPNNMQINKE
EIQGVVSGVT TAYNREQLWL ANETLIAKLQ ARCRGYLVRN GLKERMNFLK SQDPAVMCIQ
AHWKGYKQRK AFQERKQHLK DHTNEAIKIQ SMVRMHQARK KYKDRLKYFE DHIDDVVKIQ
AFIRANKARD DYKTLINAEN PPMAVVRKFV HLLDHSDQDF QEELELMRLR EEVVTNIRSN
QQLENDLNLM DIKIGLLVKN KITLQEVVSH SKKLTKKNKG QLSDMMMMNK QRGGLKALSK
EKRVKLEAYQ HLFYLLQTNP TYLAKLIFQM PQNKSTKFMD SVIFTLYNYA SNQREEYLLL
KLFKTALQEE IKSKVDQMKE IVTGNPTVIK MVVSFHRGAR GQNALRQILA PVVKEIMDDK
TLNIKTDPVD IYKGWVNQME SQTGEASKLP YDVTPEQAMS HEEVRTRLEA SIKHMKSITD
KFLSAITVSV DKIPYGMRFI SKELKDTLQE KFPDSTEDEL LKIVGNLLYY RYMNPAIVAP
DAFDIIEVSA GGQLTTEQRR NLGSVAKMLQ HAASNKMFLG DNAHLNPINE YLSSSHQKFR
RFFLSACDVP SLEDKFNVDQ YSDLVTVTKP VIYISIGEII NTHTLLLDHQ DAIAPEHNDP
IHELLTDLED VPTVESLIGE NPLPPDDPNK ELMGKTEVSL TLTNKFDVPD EANTEMDAKT
LLLNTKRLIV DVIRFQPGET LTEILDSTAS PEQEAEYQRA MQRRAIRDAK TPEKMKQVKP
VVDDSLTLQG KKDKIKSNLQ RLAELGKVHP ENRYQDLIND IAKDIRNQRR YRQRRKAELV
KLQQTNSGLN SKTTFYNMQI DSYNQYIKTC MDNLASKGKL SRKPGDNKAK KSKQVAQKYT
AARLKEKGVL ISIDDLQPNQ YKNAIFEISP SETVGVFDVK AKFMGVHLET LPLEYQDLLQ
LQYEGVAVMK LFDKATVNVN LLIFLLNKKF YGK
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