ID M4AVJ8_XIPMA Unreviewed; 1327 AA.
AC M4AVJ8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 24-JAN-2024, entry version 49.
DE SubName: Full=EvC ciliary complex subunit 2 {ECO:0000313|Ensembl:ENSXMAP00000018493.2};
GN Name=EVC2 {ECO:0000313|Ensembl:ENSXMAP00000018493.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000018493.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000018493.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000018493.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR Ensembl; ENSXMAT00000018521.2; ENSXMAP00000018493.2; ENSXMAG00000018445.2.
DR eggNOG; ENOG502QQ5U; Eukaryota.
DR GeneTree; ENSGT00940000154127; -.
DR HOGENOM; CLU_007621_0_0_1; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:InterPro.
DR InterPro; IPR022076; Limbin.
DR InterPro; IPR026501; Limbin/EVC.
DR PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR Pfam; PF12297; EVC2_like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 70..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 766..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1247..1277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 453..483
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1327 AA; 150274 MW; C1D7876A465661A4 CRC64;
MFRAHLIAQR RTLCSFFLHI KVLCLFSLSL NVACGHNVKL RAGVTEDNGE HYCCNGTKWD
TTPFTSGKCG VSNLACCCHL FVFTYLFSPC RKMDNGLLSV YGWDPSLSSA SVGPWEHSIY
SPFSYISNMV HLRKSRSTLI RHTPHQPPPQ VQNVVPPSFF EVRFYKCAQV KLDTDPPQLT
FFLLIHNLSP LGGTNLSQVA IRDSISGIKP IKTEGRVVER GYQTFAIDSL LAGSHVVVNY
TAHVRSHNNE LLDLPAFLTF SNASQNDVSM FGPLRANLTL RVNSTDRIYP NHGVHFAGFV
AGFFITLVLL LLGVLAIKFT SSRERFCLFQ RKVSKFIYAD SSMSETIKDE AAFEDKMVDV
MVLEDPQNMY QALDNLETSS LLQASSNLEA TRIQIYKDLM SCLLGGLLSR GQISAQAQQR
LLSVVHGQLL GMEGRLKEER GARMAALAGQ CNLETHEEME AEHQEQAAEK AEAERLRQHA
DQQEFLQCSR LLEKLHKQRQ SHLRRVLLVQ REDASAKVQR EIIEWRRVEL HKIFSEELEE
ATRMGELEKS TAKRLQHEYF TCQDQLEEVL DVVVANQRYV LTERSAQRKF LVHSLHSLED
LISETFSSAS SNLDSWFSHI KSGSAVPSEQ LDQLQEKAQK DLVMVRQRLD ETLNQEKRAM
RCGLINKRRE LISNMLRVHK QRQRDLSSIT KSLEEKMDEA HHLQCWQNLL TARSLELAEL
INSLDEEAAA DIRKVTMRGI QGVMADVKAI QPSAAQAVLT LLPPGAKHPM LQEEPEAGSG
KSAGQGAGAL LQGQERLHRE GKAALRTLSC TRESLQEGME QELREQKELR AHWRDFFRCL
CSSQLTLSED DRLRMKLEFQ KSLSVIDRCL VLPHAVSRSK LHAALAEWRA KSEEEMEHMQ
SKGRSTEARK KADTSEVVRF QKRLQDRIDL FEKEREMENS VMNKVMEEMQ RERDDYLLCQ
ADNLAMQMAT VVLQKAERWA KVLETSKAMV TLQSQLIQQL RERNVSELQD MAQSIHSHCL
SLEEAEQQLQ SERTELDRLG VLSHKIQTVF EGEEAREEDD VFELQPDCSM TSILQDALHK
CEQVIALTFE RFQEISTSNQ VKEELKEQIE LKRLYSNCDQ DLEFTSQLVK QSRVSDGVLL
EVLRLLLPSL PESELLSLSD ALCRKQHPVS AFTEQEHSGC AGEQNRAVPV RLREIAVRKI
IINTPNGAEK RLSAVEKLLP RSRLLRPRDA GPLLADDRGA RDVLTPAALV PQLRSDTAEE
TAHGPAGESV TSDSACGAVG SLSTGERLFV FRDPPESNNS VVVPERKKKR NFLNFKKGSV
APFTNIP
//