ID M4AW50_XIPMA Unreviewed; 813 AA.
AC M4AW50;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Espin {ECO:0000313|Ensembl:ENSXMAP00000018695.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000018695.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000018695.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000018695.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, stereocilium
CC {ECO:0000256|ARBA:ARBA00004645}.
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DR AlphaFoldDB; M4AW50; -.
DR STRING; 8083.ENSXMAP00000018695; -.
DR Ensembl; ENSXMAT00000018723.2; ENSXMAP00000018695.2; ENSXMAG00000018650.2.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000160408; -.
DR HOGENOM; CLU_017441_0_0_1; -.
DR InParanoid; M4AW50; -.
DR OMA; TAHFDIG; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0032420; C:stereocilium; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0048858; P:cell projection morphogenesis; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR24153; ESPIN; 1.
DR PANTHER; PTHR24153:SF14; ESPIN ISOFORM X1; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 3.
DR SMART; SM00248; ANK; 9.
DR SMART; SM00246; WH2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 6.
DR PROSITE; PS51082; WH2; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Hearing {ECO:0000256|ARBA:ARBA00022740};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 105..129
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 139..171
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 173..195
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 207..229
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 241..273
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 273..305
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 621..638
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 339..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 733..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..469
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..516
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..531
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..597
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..621
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..680
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 813 AA; 87207 MW; 0AB5E802CA88DCD5 CRC64;
MVVEGDRTLA AARQGDVQTL KTLLAAKVLS SDVKDVLGAS PVHHAARAGK LTCLRFLVEE
AGLQGNCLAN NGASPAHDAA ATGNLACLQW LLTQGGCRPE DKDSSGATVL HLACRFSHHE
LTEWLLKSGE VDPGASTDTG ALPVHYAAAK GDLASLRLLL GHSPNVVNSQ TKNGATPLYL
ACQEGHLEVV QYLVKDCGAD PSIRANDGMT PLHAAAQMGH STVIVWLMSF TDISLADRDG
DGATAMHFAG SRGHAKVLSW LLLHGGEIVT DNWGGTPLHD AAENGELECC QILVVNGVDL
GIRDQDGFTA ADLAEYNGHS QCAKYLRTVE NMSVEHRVLS RDPSMELESK QLDSGLSSPN
TTMPPASQAA PFDIGSPSSS LSNYDSANSS QSSTGEKRSK SAISDMQAYM DMLNPDIGAD
TANRNEIRAD GVPNPPPPPT YPPPPPPQAP PDLPPAPSYP APPPPQEPQS AEFLKVKSNL
RHVDSKSSKK EVRTVLHLTP GESHEKLRRV DSNRKSRSFN KQPSTGDYYK SLGNDTAEPR
GSKGMAPNEE AKGPAPTSEN GTTEESVSPP QPPPPPPLPP SNPMPTPPPP PPSAPTSTDN
RRPSSSSGST KSFNMMSPTG DNSELLAEIK AGKSLKPTPH SKGYTTVPSP SPSPSPTGSR
NMSGSASYEQ LSSNSVVNGD GGAGAAQPES ERKTSLADIE ALVPIHDEQG KPIPEWKRQV
MVRKLQAKMQ EEEEYKRKAE EEAQRLASMP AWRRDMMKKK MDEERKAEQQ AKQAKECEEK
QELERLRTMG YDETKLAPWQ RQIILKKGDI AKK
//
