ID   M4AX09_XIPMA            Unreviewed;      1270 AA.
AC   M4AX09;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   27-MAR-2024, entry version 52.
DE   SubName: Full=5-oxoprolinase, ATP-hydrolysing {ECO:0000313|Ensembl:ENSXMAP00000019004.2};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000019004.2, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX   PubMed=23542700; DOI=10.1038/ng.2604;
RA   Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA   Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA   Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA   Postlethwait J.H., Warren W.C.;
RT   "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT   evolutionary adaptation and several complex traits.";
RL   Nat. Genet. 45:567-572(2013).
RN   [3] {ECO:0000313|Ensembl:ENSXMAP00000019004.2}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000019004.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the oxoprolinase family.
CC       {ECO:0000256|ARBA:ARBA00010403}.
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DR   AlphaFoldDB; M4AX09; -.
DR   Ensembl; ENSXMAT00000019032.2; ENSXMAP00000019004.2; ENSXMAG00000018915.2.
DR   eggNOG; KOG1939; Eukaryota.
DR   GeneTree; ENSGT00390000013463; -.
DR   HOGENOM; CLU_002157_0_0_1; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   InterPro; IPR008040; Hydant_A_N.
DR   InterPro; IPR002821; Hydantoinase_A.
DR   InterPro; IPR003692; Hydantoinase_B.
DR   InterPro; IPR045079; Oxoprolinase_fam.
DR   PANTHER; PTHR11365:SF2; 5-OXOPROLINASE; 1.
DR   PANTHER; PTHR11365; 5-OXOPROLINASE RELATED; 1.
DR   Pfam; PF05378; Hydant_A_N; 1.
DR   Pfam; PF01968; Hydantoinase_A; 1.
DR   Pfam; PF02538; Hydantoinase_B; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT   DOMAIN          10..212
FT                   /note="Hydantoinase/oxoprolinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05378"
FT   DOMAIN          232..525
FT                   /note="Hydantoinase A/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF01968"
FT   DOMAIN          713..1234
FT                   /note="Hydantoinase B/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF02538"
SQ   SEQUENCE   1270 AA;  137923 MW;  A4C7FFE8BEC688CC CRC64;
     MAETKGKFDF AIDRGGTFTD VFARLPDGRE RVLKLLSRDP QNYKDAPTEG IRRVLEEESG
     QLFPRDQPVD TALIGWIRMG TTVATNALLE REGERTALLV TKGFKDLLHI GTQARPKLFD
     LEVAVPDVLY EEVIEVDERV VLCRDDCQLP RKDPKRSTGD SLEVWQELDL EKVEKDLRGV
     LSRGISSVAV LLLHSYTWSD HEKAVGSLAR RLGFTQVSLS SEVMPMVRAV PRGYTVCADT
     YLTPKIHQYL KGFTAGFKGG LKDVDVLFMQ SDGGLTPMEQ FCGSRAILSG PAGGVVGYAV
     TSYSQMEKKP VIGFDMGGTS TDVSRYAGQY EHVFEATTAG VTLQAPQLDI NTVAAGGGSR
     LFFRSGMFVV GPESAGAHPG PACYRKGGPL TVTDANLALG RILPPFFPKI FGPAENEPLS
     LEDTMTHFRH LTEEINSFLQ STMSVEDVAM GFIRVANEAM CRPIRALTQA KGHDTSQHVL
     ACFGGAGGQH ACSIARALGM KTVFIHKYSG VLSAYGLALA DVVEEVQEPC SLKYEQRCFS
     ELDRRMEQLC RRCRDTLSAR GFSRSDGQIS TEVFLHLRYE GTDCALMVTA DGYPGNAHSC
     RAGDFGSAFA KRYLKEFGFT IPDRAIMVDD IRVRGCGKSG INSMHKSKKG HKQAKPVMVV
     KNIHTHNSSH PCISHQSTIL VEPSCEACLT EDGDVCLAVG SDSQCAIGTE LNTVQLSIFS
     HRFMSIAEQM GRVLQRTSIS TNIKERLDFS CAVFGPDGGL VSNAPHIPVH LGAMQETVQY
     QIRSLGNELR EGDVILSNHP CAGGSHLPDL TVITPVFRKG VNRPVFFVAS RGHHADIGGV
     TPGSMPPHST SLQQEGAVFV SFKLVNGGVF QEEAVTEALM APAQHPGCSG TRNLHDNLSD
     LRAQVAANQR GSQLVGELID CYGLDVVQAY MGYIQSNAEL AVRDMLREFA QRRRRQTSGS
     LDVESEDFMD DGTPIRLRVQ INEEEGSAVF DFTGTGTEVW GNCNAPRAIT LSALIYCLRC
     MVGQDIPLNQ GCLKPIKVIV PPGSILQPSQ NAAVVGGNVL TSQRVVDVIF KAFEVCAASQ
     GCMNNISFGS ERVGYYETVA GGAGAGPGWH GRSGVHSHMT NTRITDPEIL EKRYPVILEH
     FSLRPGSGGA GKCRGGDGVV RKLLFRNKVV LSVLTERRAI RPYGLEGGED GAAGLNLLHR
     ADGRILNLGA KTSVSLEPGD MFCLYTPGGG GFGSEGDLKS GGPQRKRRRL NEVFTERGSV
     FEYRMAQEGV
//