ID M4AYQ2_XIPMA Unreviewed; 666 AA.
AC M4AYQ2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Leucine-rich repeat-containing protein 4-like {ECO:0000313|Ensembl:ENSXMAP00000019597.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000019597.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000019597.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000019597.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Synaptic cell membrane {ECO:0000256|ARBA:ARBA00034109}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_005802072.1; XM_005802015.1.
DR AlphaFoldDB; M4AYQ2; -.
DR STRING; 8083.ENSXMAP00000019597; -.
DR Ensembl; ENSXMAT00000019625.2; ENSXMAP00000019597.1; ENSXMAG00000019550.2.
DR GeneID; 102238301; -.
DR KEGG; xma:102238301; -.
DR CTD; 566572; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000159260; -.
DR HOGENOM; CLU_000288_18_24_1; -.
DR InParanoid; M4AYQ2; -.
DR OMA; SANPQNC; -.
DR OrthoDB; 4239630at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0097060; C:synaptic membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR24369; ANTIGEN BSP, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR24369:SF9; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 4; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..666
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004048326"
FT TRANSMEM 528..548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 353..442
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 606..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 666 AA; 73805 MW; 5582CBA58927156E CRC64;
MSPLAQVNVQ STWNTALLAV VSLMVPALSM CQSTGPELGS TIPQNCPGVC SCTNQLSKVV
CTRRGLIRVP PNIPANTRYL NLMENSIETI QADTFRHLHH LEVLQLGRNA IRQIEVGAFN
GLTSLNTLEL FDNRLTVIPS GAFEYLSKLR ELWLRNNPIE SIPSYAFNRV PSLMRLDLGE
LRKLEYISEG AFEGLHNLKY LNLGMCSLRE FPNLSPLLGL EELEISENVF PELKPGAFRG
LKNLRKLWIM NSAITIIERN AFDDITALVE LNLAHNNLSS LPHNLFTPLQ YLVELHLHHN
PWRCDCDVVW LSWWLRENIP TNSTCCGRCH TPVQMRGRYL VEVDQTTFQC SAPVILDAPR
DLNISAARVA EMKCRTAAMS SVRWLLPNGT VLTHSSAHPR ISVLNDGTLN FSNVLPSDTG
VYTCMVSNMA GNSNASAYLN VSNAELNTSN LSYFTTVTVE VLEPTVEETP KPKPTLPASP
SVFQPVFIST PTVLFQNTQT PRQVSIPTAR VPSGPPASLD EMMKTTKIII GCFVAVTLLA
AAMLIAFYKL RKRHQQRSTV AAARTIEIIQ MEEEVPPVPP PTSGSSGSDE TGLVLPTLVE
HNSNTFKPGY VSSSSSSRQG SYGAHWTQNN SLHRSVRQHH SHISIIADPY VIMTSHGKEK
VQETQI
//
