ID M4B262_HYAAE Unreviewed; 959 AA.
AC M4B262;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
OS Hyaloperonospora arabidopsidis (strain Emoy2) (Downy mildew agent)
OS (Peronospora arabidopsidis).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Hyaloperonospora.
OX NCBI_TaxID=559515 {ECO:0000313|EnsemblProtists:HpaP800359, ECO:0000313|Proteomes:UP000011713};
RN [1] {ECO:0000313|Proteomes:UP000011713}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Emoy2 {ECO:0000313|Proteomes:UP000011713};
RX PubMed=21148394; DOI=10.1126/science.1195203;
RA Baxter L., Tripathy S., Ishaque N., Boot N., Cabral A., Kemen E.,
RA Thines M., Ah-Fong A., Anderson R., Badejoko W., Bittner-Eddy P.,
RA Boore J.L., Chibucos M.C., Coates M., Dehal P., Delehaunty K., Dong S.,
RA Downton P., Dumas B., Fabro G., Fronick C., Fuerstenberg S.I., Fulton L.,
RA Gaulin E., Govers F., Hughes L., Humphray S., Jiang R.H., Judelson H.,
RA Kamoun S., Kyung K., Meijer H., Minx P., Morris P., Nelson J.,
RA Phuntumart V., Qutob D., Rehmany A., Rougon-Cardoso A., Ryden P.,
RA Torto-Alalibo T., Studholme D., Wang Y., Win J., Wood J., Clifton S.W.,
RA Rogers J., Van den Ackerveken G., Jones J.D., McDowell J.M., Beynon J.,
RA Tyler B.M.;
RT "Signatures of adaptation to obligate biotrophy in the Hyaloperonospora
RT arabidopsidis genome.";
RL Science 330:1549-1551(2010).
RN [2] {ECO:0000313|EnsemblProtists:HpaP800359}
RP IDENTIFICATION.
RC STRAIN=Emoy2 {ECO:0000313|EnsemblProtists:HpaP800359};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; JH597777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M4B262; -.
DR STRING; 559515.M4B262; -.
DR EnsemblProtists; HpaT800359; HpaP800359; HpaG800359.
DR VEuPathDB; FungiDB:HpaG800359; -.
DR eggNOG; KOG0923; Eukaryota.
DR HOGENOM; CLU_001832_7_1_1; -.
DR InParanoid; M4B262; -.
DR OMA; HITLMNV; -.
DR Proteomes; UP000011713; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000011713}.
FT DOMAIN 328..491
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 516..689
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 959 AA; 109758 MW; 7E3D3C6899902FFC CRC64;
MAGGSTPSKS RRADGFSRRR RRSTSNESMR DGAQDADHHP DVEVIRDFRS KRASEAEQDD
SNLTQEERDR LRDREERDAF AERLRKRDDD HTKRKRKAEE VDVSEATGGL TSDEIKQLAK
RGAVKDGQSA LSEKLRRLRE LSRQEYLKKR EEKELELLEF QLKDEAVLFE ETDKSRKEQQ
QLELSRRIFD TAKARSKKEE VEGYQIPDSY EEVDNEGNRV RKKEDLLTDR YEEEEVFHTE
QEVWEETQVK MARNKFGARE KREKQIGKDD ELVFDDQIQF ISQQMLLGHH ASEQDVQDAR
KKMEQAKHLS MQEGRKQLPV YPYRESLLEA IRNYPVIIIE GETGSGKTTQ IPQYLHEVGY
SELGAIGCTQ PRRVAAMSVA ARVAQEMNVK LGNEVGYSIR FEDCTSDKTV IKYMTDGMLL
REFLTEPDLK SYSVMIIDEA HERTLSTDIL FGLIKDIARF RDDIKIIVAS ATLDATKFSA
YFDDAPIFKI PGRMYPVDIL YTKAPEADYL DAAIVTVLQI HITQPLGDIL VFFTGQEEIE
SAEEILLQRT RGLGSRIREL LIRPIYATLP SERQAQVFEP TPEGARKVVL STNIAETSLT
IAGICYVIDT GFCKQTNYNA QTGMESLLVA PVSQAMANQR AGRAGRTAPG KCFRLYTAWS
YKNELDENSV PEIQRTNLAS VVLLMKSLGI NDLLHFDFMD PPPEKALIRS LEQLYALGAL
NGLGELTKLG RRMAEFPLDP MMSKALLASE KFGCVEEVMT VCAMLSVNNS IFYRPKDKAV
HADNARLNFA RGGGGDHITL MNVYNQWVET NYSTQWTYEN FVIMRSLKTA RDVREQLEGL
CDRVELERTS NRSDHEPIRK AICAGYFYNT AKLDNSGQYK TVKKAQLVYI HPSSCLIKLE
EVPRWVVYHE LAFTTKEYMR NVVPIKSEWL MELAPHYYKV KEVEDARSKK MPKAVGRAA
//
