ID M4B6S4_HYAAE Unreviewed; 1080 AA.
AC M4B6S4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|PROSITE:PS50166};
OS Hyaloperonospora arabidopsidis (strain Emoy2) (Downy mildew agent)
OS (Peronospora arabidopsidis).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Hyaloperonospora.
OX NCBI_TaxID=559515 {ECO:0000313|EnsemblProtists:HpaP801975, ECO:0000313|Proteomes:UP000011713};
RN [1] {ECO:0000313|Proteomes:UP000011713}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Emoy2 {ECO:0000313|Proteomes:UP000011713};
RX PubMed=21148394; DOI=10.1126/science.1195203;
RA Baxter L., Tripathy S., Ishaque N., Boot N., Cabral A., Kemen E.,
RA Thines M., Ah-Fong A., Anderson R., Badejoko W., Bittner-Eddy P.,
RA Boore J.L., Chibucos M.C., Coates M., Dehal P., Delehaunty K., Dong S.,
RA Downton P., Dumas B., Fabro G., Fronick C., Fuerstenberg S.I., Fulton L.,
RA Gaulin E., Govers F., Hughes L., Humphray S., Jiang R.H., Judelson H.,
RA Kamoun S., Kyung K., Meijer H., Minx P., Morris P., Nelson J.,
RA Phuntumart V., Qutob D., Rehmany A., Rougon-Cardoso A., Ryden P.,
RA Torto-Alalibo T., Studholme D., Wang Y., Win J., Wood J., Clifton S.W.,
RA Rogers J., Van den Ackerveken G., Jones J.D., McDowell J.M., Beynon J.,
RA Tyler B.M.;
RT "Signatures of adaptation to obligate biotrophy in the Hyaloperonospora
RT arabidopsidis genome.";
RL Science 330:1549-1551(2010).
RN [2] {ECO:0000313|EnsemblProtists:HpaP801975}
RP IDENTIFICATION.
RC STRAIN=Emoy2 {ECO:0000313|EnsemblProtists:HpaP801975};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; JH598637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M4B6S4; -.
DR STRING; 559515.M4B6S4; -.
DR EnsemblProtists; HpaT801975; HpaP801975; HpaG801975.
DR VEuPathDB; FungiDB:HpaG801975; -.
DR eggNOG; KOG2171; Eukaryota.
DR HOGENOM; CLU_003794_1_0_1; -.
DR InParanoid; M4B6S4; -.
DR OMA; ANACGCV; -.
DR Proteomes; UP000011713; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR InterPro; IPR041389; Importin_rep_6.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR PANTHER; PTHR10527:SF6; IMPORTIN-4; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR Pfam; PF03810; IBN_N; 1.
DR Pfam; PF18829; Importin_rep_6; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000011713};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 27..93
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
FT REPEAT 402..440
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ SEQUENCE 1080 AA; 117485 MW; 62884A19373D470E CRC64;
MVDFTPEQLE ACLLQLTHPD TEQIKQAEAV LKTYTKQIAS VGGLLTQLQL STKPEVRQLA
ALMLRKKIFK HWPKLDAAAQ AQAKQVLLSR AAEDPVHVVR STVANLIAAL ALHEVPAGNW
PELMVFINTC ANSTSVDQRE MSMKLLQLLG EGMGTSLQPH FHDLKQLYAK ALQDPENLQV
RVGAMRAACS LVDFLEEADL RGFRDLVPLM ITVLQQCVSS GAEAEAVEFM DVFSEIASHP
FPILDQAFPQ FIELLLQIIL AEQLEVSTRA SASYAIGEFI KKKPKTIGKK NLVSKIFTTM
LDIVAADEAV SCGLISNLLA RENKVDGEDD DEDDESPGHL AQQTLDSLAL SVPAKYLNPV
VFGICNECIT SQDARKRKAG VLALGIMSEG CCEFMCQNLN ELLPAVYRVA QDADQHVREA
SCFALGQFAE FLQPTITDHF ADILPIGLTL LDNASKVIKA TALYVLDEIT QSMESDQVLP
YLEILMTKLV DVLRTGSPQL QKMALDAVGS IAIGAKDAFL PYFASVAELI QPFSAITDPK
FFFLRGAAIE CLGYLATALG KEPFRPYFAP SMPFVFASIE LDDSELKEQA FVYFINVSSI
FKEEFAPFLD QAATHVLQAI VSDEGLRVMD DDDDVLEGLN SDDEADTDDN VLRHISIRTD
ALNSKVRAVA AVEELALNCG GPVFEPYIPK FLEALAPLTE YIHEDVRGAV AEALAALVIC
SFEASHVSSG DVQVWTKGDF NKNILTPNNA VIASAVMKSL VEELLEDPEE VVVVKAFNAV
KAMSARVGPV VTMNHMSELM RITKTVLSHE HVCQTSHEED EDDEEEEGGS VLESASELIG
VLAKCYGEHF LATFQELFPA LMSFATGLRA ARDRAAAVGC FAEVLRELGP AGLGFVESVF
PVVLQGLASD NYVLKANSAF CVGILAEISG DKLASAYEQM LQALRPLFET SDNDEVVIDN
ACAAVARMII AGGVNMPLEV VLPVFLGALP LKADMDESAV CFQCLNGLVS SQNPVVLNLM
PQVLDVYSKA LAPTSIVEEE TQTEVKVCVR GLLQTYEAQM KEIVTQMSPG AQTALSSALN
//
