ID   M4B7Q8_HYAAE            Unreviewed;       617 AA.
AC   M4B7Q8;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=Translation initiation factor eIF2B subunit delta {ECO:0000256|ARBA:ARBA00044147};
DE   AltName: Full=eIF2B GDP-GTP exchange factor subunit delta {ECO:0000256|ARBA:ARBA00044356};
OS   Hyaloperonospora arabidopsidis (strain Emoy2) (Downy mildew agent)
OS   (Peronospora arabidopsidis).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Hyaloperonospora.
OX   NCBI_TaxID=559515 {ECO:0000313|EnsemblProtists:HpaP802310, ECO:0000313|Proteomes:UP000011713};
RN   [1] {ECO:0000313|Proteomes:UP000011713}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Emoy2 {ECO:0000313|Proteomes:UP000011713};
RX   PubMed=21148394; DOI=10.1126/science.1195203;
RA   Baxter L., Tripathy S., Ishaque N., Boot N., Cabral A., Kemen E.,
RA   Thines M., Ah-Fong A., Anderson R., Badejoko W., Bittner-Eddy P.,
RA   Boore J.L., Chibucos M.C., Coates M., Dehal P., Delehaunty K., Dong S.,
RA   Downton P., Dumas B., Fabro G., Fronick C., Fuerstenberg S.I., Fulton L.,
RA   Gaulin E., Govers F., Hughes L., Humphray S., Jiang R.H., Judelson H.,
RA   Kamoun S., Kyung K., Meijer H., Minx P., Morris P., Nelson J.,
RA   Phuntumart V., Qutob D., Rehmany A., Rougon-Cardoso A., Ryden P.,
RA   Torto-Alalibo T., Studholme D., Wang Y., Win J., Wood J., Clifton S.W.,
RA   Rogers J., Van den Ackerveken G., Jones J.D., McDowell J.M., Beynon J.,
RA   Tyler B.M.;
RT   "Signatures of adaptation to obligate biotrophy in the Hyaloperonospora
RT   arabidopsidis genome.";
RL   Science 330:1549-1551(2010).
RN   [2] {ECO:0000313|EnsemblProtists:HpaP802310}
RP   IDENTIFICATION.
RC   STRAIN=Emoy2 {ECO:0000313|EnsemblProtists:HpaP802310};
RG   EnsemblProtists;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}.
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC       {ECO:0000256|ARBA:ARBA00007251, ECO:0000256|RuleBase:RU003814}.
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DR   EMBL; JH597876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; M4B7Q8; -.
DR   STRING; 559515.M4B7Q8; -.
DR   EnsemblProtists; HpaT802310; HpaP802310; HpaG802310.
DR   VEuPathDB; FungiDB:HpaG802310; -.
DR   eggNOG; KOG1467; Eukaryota.
DR   HOGENOM; CLU_016218_3_3_1; -.
DR   InParanoid; M4B7Q8; -.
DR   Proteomes; UP000011713; Unassembled WGS sequence.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR042529; IF_2B-like_C.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   PANTHER; PTHR10233; TRANSLATION INITIATION FACTOR EIF-2B; 1.
DR   PANTHER; PTHR10233:SF14; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA; 1.
DR   Pfam; PF01008; IF-2B; 1.
DR   SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011713}.
FT   REGION          95..201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          537..559
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        96..174
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        177..198
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   617 AA;  67679 MW;  506B52B908128B1C CRC64;
     MTDKSMIDDD KNRTTKRPKS KTTYECAILF VQFCTKNSLL TLYLTGALEG WSPAAKPETT
     ETVSSMERLS LEGPAVNSSD QTGMMTSLRN VPIIVNETED RAKNEDPTLK KLEKETDGEV
     PDTKKLSKAE RKKLAAEAFA KTGGVSKREK RTKAERRAQQ EASRSQHEGL PKPSKKSSDT
     VAASPIAGGT SATNAAAGSL VPPSPVVHVR LQYDDAKKIA RRSKAALVVR TQAQKQVEMF
     SHLPQYERES SLSLNVGFSN KEEVHPAVLA LGLKYAEKKI SGSNARCIAM ITAFQQVIQD
     YVTPPDKQLG RDLDKRLRPL IQYLIDCRPH GIGMGNAIRR LRRVIGSSLP EWSEEEAKRR
     ICDEMDDYVQ TRILLASRAV SKNAQSKISA GDVILTYARA NVVENLLLNT AKSSPELAAT
     LRVIVVDSRP HYEGRKLVSV LANAGLQCSY LQINALSYIM REVTKVFLGA AAFMSNGVAV
     ARVGTALVAM SAHEANVPVL FCCETYKFSE RVQLDAITHN ELGDPDELVS SYCIDKPRSR
     RRMGGGDTDD ASSSSSSGHI LSDWRDLADL KLLNLVYDVT PIDYVSMVVT ELGMVPPTSI
     PAVLREYSRD GLVDGSL
//