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Database: UniProt
Entry: M4BEF3_HYAAE
LinkDB: M4BEF3_HYAAE
Original site: M4BEF3_HYAAE 
ID   M4BEF3_HYAAE            Unreviewed;       952 AA.
AC   M4BEF3;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   31-JUL-2019, entry version 27.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblProtists:HpaP804671};
OS   Hyaloperonospora arabidopsidis (strain Emoy2) (Downy mildew agent)
OS   (Peronospora arabidopsidis).
OC   Eukaryota; Stramenopiles; Oomycetes; Peronosporales; Peronosporaceae;
OC   Hyaloperonospora.
OX   NCBI_TaxID=559515 {ECO:0000313|EnsemblProtists:HpaP804671, ECO:0000313|Proteomes:UP000011713};
RN   [1] {ECO:0000313|EnsemblProtists:HpaP804671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Emoy2 {ECO:0000313|EnsemblProtists:HpaP804671};
RX   PubMed=21148394; DOI=10.1126/science.1195203;
RA   Baxter L., Tripathy S., Ishaque N., Boot N., Cabral A., Kemen E.,
RA   Thines M., Ah-Fong A., Anderson R., Badejoko W., Bittner-Eddy P.,
RA   Boore J.L., Chibucos M.C., Coates M., Dehal P., Delehaunty K.,
RA   Dong S., Downton P., Dumas B., Fabro G., Fronick C.,
RA   Fuerstenberg S.I., Fulton L., Gaulin E., Govers F., Hughes L.,
RA   Humphray S., Jiang R.H., Judelson H., Kamoun S., Kyung K., Meijer H.,
RA   Minx P., Morris P., Nelson J., Phuntumart V., Qutob D., Rehmany A.,
RA   Rougon-Cardoso A., Ryden P., Torto-Alalibo T., Studholme D., Wang Y.,
RA   Win J., Wood J., Clifton S.W., Rogers J., Van den Ackerveken G.,
RA   Jones J.D., McDowell J.M., Beynon J., Tyler B.M.;
RT   "Signatures of adaptation to obligate biotrophy in the
RT   Hyaloperonospora arabidopsidis genome.";
RL   Science 330:1549-1551(2010).
RN   [2] {ECO:0000313|EnsemblProtists:HpaP804671}
RP   IDENTIFICATION.
RC   STRAIN=Emoy2 {ECO:0000313|EnsemblProtists:HpaP804671};
RG   EnsemblProtists;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822}.
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DR   EMBL; JH598174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 272952.HpaP804671; -.
DR   EnsemblProtists; HpaT804671; HpaP804671; HpaG804671.
DR   InParanoid; M4BEF3; -.
DR   OMA; FIESMVG; -.
DR   Proteomes; UP000011713; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 2.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 2.
DR   Pfam; PF01007; IRK; 2.
DR   Pfam; PF17655; IRK_C; 2.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011713};
KW   Ion channel {ECO:0000256|RuleBase:RU003822};
KW   Ion transport {ECO:0000256|RuleBase:RU003822};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011713};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822}.
FT   TRANSMEM     99    118       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    681    703       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    723    741       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    747    772       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      127    184       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      282    382       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   DOMAIN      666    778       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      782    932       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION      427    467       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      590    642       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    439    466       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    610    633       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   952 AA;  106970 MW;  2CE4E8569D4E17FE CRC64;
     MPASKKRIQN RGTLDVGTQR VPAALKDWVH IWHGVKVKNG VQGNTSIFHA GSRVEDMPFW
     KQFIRLPSNS LFPSVSTNAN PRTPYKDFLY VLLNMRWPML LMVLLAVFMV NLFFFAAVTC
     CICGDPTGFL EAFNLSYQTF TTIGFGVVYP THTCGNVIMS VESFASMMVV SAGTGLVFAK
     FAKPQAKVAF SKVCVVQPYG EKHLALVVRV ANATQSRDVT HDVIMEAAFK VNLLRVEHKT
     RHVRAHDNEV TLKRRLSQPP SAQSVENAAD DPACSTKVLT SYNLKLQQNN FITFRMGVAV
     VHLIDESSPL YQMSKNDIAQ SDMLVEVAMS GVDSTLQDTV SERYIYTAAN LVWGYRFAEM
     LEFNEQNAEV IMDFARLSTV ESAPIDDAQY LQLVGSNERM CPPNSHESEG KDVACQCSQQ
     KVRASYYHKD RPPPHDQDLF SESSANDVSS SSSASGDSQS TVTDNEVPVL PHPFVSLSQK
     PGPKKSAMGL EPLFEPLLQQ PFGTQRIPKA PSAETRAARR GGLQIWRDID RYHPEIERAT
     LSEGRLATVD GVDVNVRHRS WDAHHDEVGC RSFESPDVLR PRHLLQREVA GPASMGGNAC
     SSSQEKEQKN DLTAINDPDG RDGRGEVDEG VSQRRQRPQT TMSVVSMEVE DTPRFLRISP
     VHIPKSFSFM RIYQSALHVR WPRIIVVFVL SFLVINFTFG LLYWFDMDHI AVYSDMVVSN
     YELAFYMSVH TLATIGYGSI APKPDAVYMN VVVFIESMVG IITVTIITGI AWSKFARPRA
     HIHFSSHMTI TTIYGHRCLV FRAANTRHSG EVHDNFFRIG VILTNRRTGL RQMYDVPLVT
     AEWPSIKLPA TLIHVIDENS PFDKFYSMED LSKSRVAVIA LLTGLDTTFS ENVYARKMYF
     WDDFAYDMRF DDFAVIERDR VTVDYECFDR LIPNDQDEAV GTTPVRSADA VV
//
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