ID M4BG86_HYAAE Unreviewed; 473 AA.
AC M4BG86;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Guanylate cyclase domain-containing protein {ECO:0000259|PROSITE:PS50125};
OS Hyaloperonospora arabidopsidis (strain Emoy2) (Downy mildew agent)
OS (Peronospora arabidopsidis).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Hyaloperonospora.
OX NCBI_TaxID=559515 {ECO:0000313|EnsemblProtists:HpaP805307, ECO:0000313|Proteomes:UP000011713};
RN [1] {ECO:0000313|Proteomes:UP000011713}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Emoy2 {ECO:0000313|Proteomes:UP000011713};
RX PubMed=21148394; DOI=10.1126/science.1195203;
RA Baxter L., Tripathy S., Ishaque N., Boot N., Cabral A., Kemen E.,
RA Thines M., Ah-Fong A., Anderson R., Badejoko W., Bittner-Eddy P.,
RA Boore J.L., Chibucos M.C., Coates M., Dehal P., Delehaunty K., Dong S.,
RA Downton P., Dumas B., Fabro G., Fronick C., Fuerstenberg S.I., Fulton L.,
RA Gaulin E., Govers F., Hughes L., Humphray S., Jiang R.H., Judelson H.,
RA Kamoun S., Kyung K., Meijer H., Minx P., Morris P., Nelson J.,
RA Phuntumart V., Qutob D., Rehmany A., Rougon-Cardoso A., Ryden P.,
RA Torto-Alalibo T., Studholme D., Wang Y., Win J., Wood J., Clifton S.W.,
RA Rogers J., Van den Ackerveken G., Jones J.D., McDowell J.M., Beynon J.,
RA Tyler B.M.;
RT "Signatures of adaptation to obligate biotrophy in the Hyaloperonospora
RT arabidopsidis genome.";
RL Science 330:1549-1551(2010).
RN [2] {ECO:0000313|EnsemblProtists:HpaP805307}
RP IDENTIFICATION.
RC STRAIN=Emoy2 {ECO:0000313|EnsemblProtists:HpaP805307};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; JH598226; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M4BG86; -.
DR STRING; 559515.M4BG86; -.
DR EnsemblProtists; HpaT805307; HpaP805307; HpaG805307.
DR VEuPathDB; FungiDB:HpaG805307; -.
DR eggNOG; KOG0618; Eukaryota.
DR HOGENOM; CLU_018845_0_0_1; -.
DR InParanoid; M4BG86; -.
DR OMA; KEASKGW; -.
DR Proteomes; UP000011713; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR PANTHER; PTHR43081:SF1; PH-SENSITIVE ADENYLATE CYCLASE RV1264; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011713};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 68..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 218..348
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 473 AA; 52503 MW; AD0BC7B73D495331 CRC64;
MHFAAALWAL PLTYELSKIA TKSMDRGMTK EQAKIRLYLV LGHAFIASFS IAEAVLSLVK
GGYSSYTYRL ALCIYVMQVT TLVYMGVVLF LLKRNGRDVE SINGRFQASP VYHRLKRILF
AYALSALQYE CTSLFLYVRT PRNEMTFNYI GLSQVLYNAT GLALALSTGC SLPCTLRFCG
CCFPDEMLVQ LVVEANRPQV TGVHKRSKFV APPVANPVFV VTDIESSSAL WASGDSKVMQ
RAIQVHDDTL RSLLTLYRGY EITTAGDSFQ LAFHTIREAV AYCLDVQLQL LAADWPKDLH
GLVAATKKHR VGHRVIFRGL RVRMGIHDAT GSDGHLHHSP HAVTGKTVYT GAAEVIAGEV
SDVGAGGQIL ITRRIADWLM ANRDALPRDF SVTYLCDYLV PQVNMHVAVY EVLPEVLSRR
KRIFAKDQHK RIPQVVIDRS TSGSSSLGTP MNSPASWFFI PCTPERGSLV CSR
//
