ID M4BPF0_HYAAE Unreviewed; 866 AA.
AC M4BPF0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=DNA mismatch repair proteins mutS family domain-containing protein {ECO:0000259|PROSITE:PS00486};
OS Hyaloperonospora arabidopsidis (strain Emoy2) (Downy mildew agent)
OS (Peronospora arabidopsidis).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Hyaloperonospora.
OX NCBI_TaxID=559515 {ECO:0000313|EnsemblProtists:HpaP808289, ECO:0000313|Proteomes:UP000011713};
RN [1] {ECO:0000313|Proteomes:UP000011713}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Emoy2 {ECO:0000313|Proteomes:UP000011713};
RX PubMed=21148394; DOI=10.1126/science.1195203;
RA Baxter L., Tripathy S., Ishaque N., Boot N., Cabral A., Kemen E.,
RA Thines M., Ah-Fong A., Anderson R., Badejoko W., Bittner-Eddy P.,
RA Boore J.L., Chibucos M.C., Coates M., Dehal P., Delehaunty K., Dong S.,
RA Downton P., Dumas B., Fabro G., Fronick C., Fuerstenberg S.I., Fulton L.,
RA Gaulin E., Govers F., Hughes L., Humphray S., Jiang R.H., Judelson H.,
RA Kamoun S., Kyung K., Meijer H., Minx P., Morris P., Nelson J.,
RA Phuntumart V., Qutob D., Rehmany A., Rougon-Cardoso A., Ryden P.,
RA Torto-Alalibo T., Studholme D., Wang Y., Win J., Wood J., Clifton S.W.,
RA Rogers J., Van den Ackerveken G., Jones J.D., McDowell J.M., Beynon J.,
RA Tyler B.M.;
RT "Signatures of adaptation to obligate biotrophy in the Hyaloperonospora
RT arabidopsidis genome.";
RL Science 330:1549-1551(2010).
RN [2] {ECO:0000313|EnsemblProtists:HpaP808289}
RP IDENTIFICATION.
RC STRAIN=Emoy2 {ECO:0000313|EnsemblProtists:HpaP808289};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271}.
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DR EMBL; JH598500; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M4BPF0; -.
DR STRING; 559515.M4BPF0; -.
DR EnsemblProtists; HpaT808289; HpaP808289; HpaG808289.
DR VEuPathDB; FungiDB:HpaG808289; -.
DR eggNOG; ENOG502QUUG; Eukaryota.
DR HOGENOM; CLU_002472_4_0_1; -.
DR InParanoid; M4BPF0; -.
DR OMA; DTWIMRR; -.
DR Proteomes; UP000011713; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000011713}.
FT DOMAIN 741..757
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 215..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 866 AA; 95910 MW; F6DEC1F54851A677 CRC64;
MLLRRLCRGR RRHPRASISV ETDKFLYCHW QYRSSIQWLS SAAGSRVDSE NSTDNEATKT
TPMVAQYLAR KKEYPDSFVE KLPASSAKQR GLNSLVDRQV VRIVTPGSLV EDTILTPKEN
NYLASLYYKE GTWGLAWADL STGEFVSTTS TGDKLSSAIL RCSPKEILLP SLTDETEIET
MGLQAIDMPP NAVALLEAVL PDTCMKTFRP AASFIPQTPG SRRQGRASTI NAPDSPEKAA
VSAILDYVRF TYRGSSALVR EPLHVESSDH MIIDSSAWRG LELTKSLSGS KASSLLQTID
QTTTPGGSRL LAAQLSSPLM NLTLLDRRLN AVSYFYDQEH LLQCTRKQLA EVFDMERNLQ
RLSIGIGTPK DLKNVASTIV EAENLVDLVR TNELHRRSRL PDLPGKSTLS FPTLLDDCCH
GLVANEQQRE RIRKAADEIH AALKDDYASL NSKSGFVRAG YSPELDKWRT ILRHDPKSPE
KQELQAKYRE LVGSTRLRVV FQVEKGYFLD VPHDENTKLL KTNRGRRELE KLTLFQSLKN
SVRYRSEELR QLNRELTEAA VEVERVENGI FTALCDQVLA VRIELQTMAH AISQIDVVCS
HAQMALDRNF TRPVLDGSCE LHVEDGRHAV VEAAHLRGKN ARSMRTFVPN SLHLAAAPVG
SCWLLTGPNM GGKSTFLRQS AHLVILAQMG SFVPAKFARV GLVDKLFCRV GSADDLAADK
STFMVEMQET STILTQATSR SLVLMDEVGR GTAVNDGIAI AGAVLETLCA RQTRTLFATH
FTALSNLVGG TCSGNLRPYR MEVIEHQVEG QMTQLVFSHR VVEGLASQSY GINTAALAGC
PPNVVARATE LLSELTQDQD KSARHD
//
