ID M4BQ28_HYAAE Unreviewed; 439 AA.
AC M4BQ28;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Copper transport protein {ECO:0000256|RuleBase:RU367022};
OS Hyaloperonospora arabidopsidis (strain Emoy2) (Downy mildew agent)
OS (Peronospora arabidopsidis).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Hyaloperonospora.
OX NCBI_TaxID=559515 {ECO:0000313|EnsemblProtists:HpaP808517, ECO:0000313|Proteomes:UP000011713};
RN [1] {ECO:0000313|Proteomes:UP000011713}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Emoy2 {ECO:0000313|Proteomes:UP000011713};
RX PubMed=21148394; DOI=10.1126/science.1195203;
RA Baxter L., Tripathy S., Ishaque N., Boot N., Cabral A., Kemen E.,
RA Thines M., Ah-Fong A., Anderson R., Badejoko W., Bittner-Eddy P.,
RA Boore J.L., Chibucos M.C., Coates M., Dehal P., Delehaunty K., Dong S.,
RA Downton P., Dumas B., Fabro G., Fronick C., Fuerstenberg S.I., Fulton L.,
RA Gaulin E., Govers F., Hughes L., Humphray S., Jiang R.H., Judelson H.,
RA Kamoun S., Kyung K., Meijer H., Minx P., Morris P., Nelson J.,
RA Phuntumart V., Qutob D., Rehmany A., Rougon-Cardoso A., Ryden P.,
RA Torto-Alalibo T., Studholme D., Wang Y., Win J., Wood J., Clifton S.W.,
RA Rogers J., Van den Ackerveken G., Jones J.D., McDowell J.M., Beynon J.,
RA Tyler B.M.;
RT "Signatures of adaptation to obligate biotrophy in the Hyaloperonospora
RT arabidopsidis genome.";
RL Science 330:1549-1551(2010).
RN [2] {ECO:0000313|EnsemblProtists:HpaP808517}
RP IDENTIFICATION.
RC STRAIN=Emoy2 {ECO:0000313|EnsemblProtists:HpaP808517};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU367022}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU367022}.
CC -!- SIMILARITY: Belongs to the copper transporter (Ctr) (TC 1.A.56) family.
CC SLC31A subfamily. {ECO:0000256|ARBA:ARBA00006921,
CC ECO:0000256|RuleBase:RU367022}.
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DR EMBL; JH598544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M4BQ28; -.
DR EnsemblProtists; HpaT808517; HpaP808517; HpaG808517.
DR VEuPathDB; FungiDB:HpaG808517; -.
DR eggNOG; KOG3386; Eukaryota.
DR HOGENOM; CLU_030472_0_0_1; -.
DR InParanoid; M4BQ28; -.
DR OMA; IQMTIAY; -.
DR Proteomes; UP000011713; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005375; F:copper ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR007274; Cop_transporter.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR PANTHER; PTHR12483:SF27; COPPER TRANSPORT PROTEIN; 1.
DR PANTHER; PTHR12483; SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS; 1.
DR Pfam; PF04145; Ctr; 1.
DR Pfam; PF00403; HMA; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 3: Inferred from homology;
KW Copper {ECO:0000256|RuleBase:RU367022};
KW Copper transport {ECO:0000256|RuleBase:RU367022};
KW Ion transport {ECO:0000256|RuleBase:RU367022};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367022};
KW Reference proteome {ECO:0000313|Proteomes:UP000011713};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367022};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367022}; Transport {ECO:0000256|RuleBase:RU367022}.
FT TRANSMEM 248..266
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367022"
FT TRANSMEM 295..316
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367022"
FT TRANSMEM 322..340
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367022"
FT DOMAIN 357..421
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT REGION 186..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 439 AA; 47168 MW; 132AED10BFDB157B CRC64;
MPAMQLHRGL ASLAMSSTDY TCPVCGMSTL DSGYDNENYV TMMHGQKVYS CGMAARPFPA
YSSDLTDTAY LAANMAEFII NQTDVDAYAK CTSACNECVD GILDPVSGAT VKTDNYVYVC
LKNGQKIYFS SQVNKNSYLT SVNKEPRYLV DSIICAGSTC SDATTITTLS PAAQSFVADL
SASTAQGTTS APSTSSRSTA TESDEPSTGA DFCSGQGSVM FNGFQLSRHG SCVMLLFQPW
VLNSGGKYAI GFVACFLIAL LNETLVKGRE VVRQRLLAAR KLRPSDKLHK MQCKLILAVL
YMTQMTIAYF AMLVVMTYET GLFLALIAGF GTGFLLYKNL DQDVTDERGS WRFTDPSTVR
IQVSGMSCMK NCGTTVENAL KETPGVTKAV VVFDERAAYV AGSAHSGDLV EAVAAVGFSA
EMSNNQSVRS PLASKSLEH
//
