ID M4BWU0_HYAAE Unreviewed; 1192 AA.
AC M4BWU0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=FYVE-type domain-containing protein {ECO:0000259|PROSITE:PS50178};
OS Hyaloperonospora arabidopsidis (strain Emoy2) (Downy mildew agent)
OS (Peronospora arabidopsidis).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Hyaloperonospora.
OX NCBI_TaxID=559515 {ECO:0000313|EnsemblProtists:HpaP810991, ECO:0000313|Proteomes:UP000011713};
RN [1] {ECO:0000313|Proteomes:UP000011713}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Emoy2 {ECO:0000313|Proteomes:UP000011713};
RX PubMed=21148394; DOI=10.1126/science.1195203;
RA Baxter L., Tripathy S., Ishaque N., Boot N., Cabral A., Kemen E.,
RA Thines M., Ah-Fong A., Anderson R., Badejoko W., Bittner-Eddy P.,
RA Boore J.L., Chibucos M.C., Coates M., Dehal P., Delehaunty K., Dong S.,
RA Downton P., Dumas B., Fabro G., Fronick C., Fuerstenberg S.I., Fulton L.,
RA Gaulin E., Govers F., Hughes L., Humphray S., Jiang R.H., Judelson H.,
RA Kamoun S., Kyung K., Meijer H., Minx P., Morris P., Nelson J.,
RA Phuntumart V., Qutob D., Rehmany A., Rougon-Cardoso A., Ryden P.,
RA Torto-Alalibo T., Studholme D., Wang Y., Win J., Wood J., Clifton S.W.,
RA Rogers J., Van den Ackerveken G., Jones J.D., McDowell J.M., Beynon J.,
RA Tyler B.M.;
RT "Signatures of adaptation to obligate biotrophy in the Hyaloperonospora
RT arabidopsidis genome.";
RL Science 330:1549-1551(2010).
RN [2] {ECO:0000313|EnsemblProtists:HpaP810991}
RP IDENTIFICATION.
RC STRAIN=Emoy2 {ECO:0000313|EnsemblProtists:HpaP810991};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; JH598007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M4BWU0; -.
DR STRING; 559515.M4BWU0; -.
DR EnsemblProtists; HpaT810991; HpaP810991; HpaG810991.
DR VEuPathDB; FungiDB:HpaG810991; -.
DR eggNOG; ENOG502RWHM; Eukaryota.
DR HOGENOM; CLU_271745_0_0_1; -.
DR InParanoid; M4BWU0; -.
DR OMA; YRAIKWH; -.
DR Proteomes; UP000011713; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13510; FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED; 1.
DR PANTHER; PTHR13510:SF44; RABENOSYN-5; 1.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000011713};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 316..375
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 381..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 769..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 927..956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1000..1021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 695..747
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 427..445
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..955
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1192 AA; 133445 MW; A9923B5EB8C15A1A CRC64;
MLEFPLHDGF FPQIALSREE VKYYKRLGKE RVTQLIRIIE DADCAYKWTS ATRDRRSHRS
RLPGRSRLSF ESKDDVAIVC ERANFLDFQP TNKSAQASTL LKASVQVSDI QVDEILRAVA
KVKTKEFRKT MRYMHDDGFV DGRTLFTFPR ESVRPAKNSA GRAVSSSSSS CFSYRAIKWH
ALKTQRRRHG EEEKKVDFCF LEYAGKKKPH PGSNVVGFCI QESISRDREV PTLENFGIAR
GYLSRMGIII SKTHQANTFK VTAICQIDGD LNPIVRSVLE ELMEKTVGAV ARIPGLVARQ
RVSSLRFVEQ WQWVPNSDRK ACAVCLRGFY FRRKHHCRTC GEVVCSSCAL LRELEEPIFD
ITHLRVCSAC MTSAGARQQE QQCSAQSNTG TGDEPPVSGT SNDTESYIRG LRSPQHNSYE
DMVFHMRESR DRDRRQSDLA GDVLETDTEL KPASPLRNLT VSPEKLRAQD KIQALTEVVT
RIREVRDTIN LSMSEAAYGQ HQDEENSEEI EEFNDMYSEI TYIQEALESS VLNYDAALAN
ATNAAPAMYY SGPSTRSQED GGISEPDEDD GMTANQFESV ARITFAAARA TKEAGQAFLS
VGERQHVQHD YRYGKTTHLE LDDDVSASSA SVASYPTLTG SYNSSGQSID PYSASNYEKI
MANYQPEQDG SEHDYEDDRH SSYNFADSVR RVTEIHELEK KILDLQRSLE EAQHKLSVID
SDEPEPEVRL RQRLDAARDR SAQLELDSVF EIFGEQGDGK GATILGETAS SESLSDTGMS
SPTKTIRSRG LTTQDLVSEL RGVMASIDTP VRDSSEPRKS VLRPSIHQMP SSVDKSSMSS
RMLPPVMASP LAISMNPSSQ PASIYYSAHP MPSKPKGGRP VNSDLNISRG SIKKHHYGHL
SGSNRPSAAP TEGSYLQALG TTCGTRCGGD NDDDNDHDDD EFASLSSDEE SYNDSYDEMS
MFGSDDFREA QLRKYHNGSD PFFIEEDLGA LLKLRKAAEA EASPPNDLAT SPYSPSSLDP
AMEMDERNDL RHLMAGLVRR RSCSLPFPSG QMGGASSGEF LHDKPSWSDD APDRVPTVHQ
VKEALHEVRA CLASCRCECP SDTDRTRKLT SIFKVLGSLH REGVRSKFRT LQHDDIRYSK
MMQTTPSIIK LLKLAGYVSL QQKLTMRRVD QDYLSLFLHE LERELYSSSI ET
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