ID M4BYZ1_HYAAE Unreviewed; 1722 AA.
AC M4BYZ1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
OS Hyaloperonospora arabidopsidis (strain Emoy2) (Downy mildew agent)
OS (Peronospora arabidopsidis).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Hyaloperonospora.
OX NCBI_TaxID=559515 {ECO:0000313|EnsemblProtists:HpaP811789, ECO:0000313|Proteomes:UP000011713};
RN [1] {ECO:0000313|Proteomes:UP000011713}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Emoy2 {ECO:0000313|Proteomes:UP000011713};
RX PubMed=21148394; DOI=10.1126/science.1195203;
RA Baxter L., Tripathy S., Ishaque N., Boot N., Cabral A., Kemen E.,
RA Thines M., Ah-Fong A., Anderson R., Badejoko W., Bittner-Eddy P.,
RA Boore J.L., Chibucos M.C., Coates M., Dehal P., Delehaunty K., Dong S.,
RA Downton P., Dumas B., Fabro G., Fronick C., Fuerstenberg S.I., Fulton L.,
RA Gaulin E., Govers F., Hughes L., Humphray S., Jiang R.H., Judelson H.,
RA Kamoun S., Kyung K., Meijer H., Minx P., Morris P., Nelson J.,
RA Phuntumart V., Qutob D., Rehmany A., Rougon-Cardoso A., Ryden P.,
RA Torto-Alalibo T., Studholme D., Wang Y., Win J., Wood J., Clifton S.W.,
RA Rogers J., Van den Ackerveken G., Jones J.D., McDowell J.M., Beynon J.,
RA Tyler B.M.;
RT "Signatures of adaptation to obligate biotrophy in the Hyaloperonospora
RT arabidopsidis genome.";
RL Science 330:1549-1551(2010).
RN [2] {ECO:0000313|EnsemblProtists:HpaP811789}
RP IDENTIFICATION.
RC STRAIN=Emoy2 {ECO:0000313|EnsemblProtists:HpaP811789};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
CC coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|ARBA:ARBA00009535, ECO:0000256|PIRNR:PIRNR002290}.
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DR EMBL; JH598052; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 559515.M4BYZ1; -.
DR EnsemblProtists; HpaT811789; HpaP811789; HpaG811789.
DR VEuPathDB; FungiDB:HpaG811789; -.
DR eggNOG; KOG0985; Eukaryota.
DR HOGENOM; CLU_002136_0_0_1; -.
DR InParanoid; M4BYZ1; -.
DR OMA; HCYDLLH; -.
DR Proteomes; UP000011713; Unassembled WGS sequence.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IEA:InterPro.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.730; -; 1.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR015348; Clathrin_H-chain_linker_core.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF1; CLATHRIN HEAVY CHAIN; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 7.
DR Pfam; PF09268; Clathrin-link; 1.
DR Pfam; PF13838; Clathrin_H_link; 1.
DR Pfam; PF01394; Clathrin_propel; 1.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 1.
DR SMART; SM00299; CLH; 7.
DR SUPFAM; SSF48371; ARM repeat; 6.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 7.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176, ECO:0000256|PIRNR:PIRNR002290};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|PIRNR:PIRNR002290};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002290};
KW Reference proteome {ECO:0000313|Proteomes:UP000011713};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 339..359
FT /note="Clathrin heavy chain linker core motif"
FT /evidence="ECO:0000259|Pfam:PF09268"
SQ SEQUENCE 1722 AA; 194531 MW; 0B4DCF85EDDE608B CRC64;
MAQDLPITFG EVLHLSSLGV NLDYVKFGTT TMESDKFVCV CEQVNGQASV VIVDMAAGNT
VQRRPINAEA AIMNPVSKVI ALRAENQLQI FNMELRAKMK SHLMNEAVVF WRWISVNTIA
IVTASAVFHW SIEGDSSPVK IFDRHANLGA GTQIISYEAS ADNQWMLLVG ISQGDGGRIV
GNMQLYSMEK KVSQVLLGHA GAFAQMKPPS RTDDAQVLIF AGTKGDGQPT QLFIMEVGRD
RDAPGGVFRL PPQPIPFAAD AQADFPVSML VTPGDDVVYM ITKMGYLFLF DTHSGKPVYR
ARVSQDTTFV TCLESKSKGM LGITRRGQLL HFAINKTKLV PYVVNTLRDS QLALSLATRL
DLPGAEELYF TEFNRLVSVN DIQGAARLAA ASPQGALRTP QTIQRFQQMP AQPGQPQPIL
QYFSVLLEKG TLNKMESIEL ARPVLMQGRG QLLQKWLSED KLECSEELGD LVAQSDTTMA
LSVYLRAEVP EKVINCFVQR GDFDKIVAYA VQTNYRCDYT FMLQNLVRAN PQGALDFAQK
LAVAENGPLV DVNAVVDIFM QVNRIQETTA FLLEALKNNR PEEGYLQTRL LEINLLGGSP
QVADAILSNN MFTHYDRPRI AALCEKAGLF QRALEHYTEL ADLKRVIVNT QAINHEFIVT
FFGTLTSEIS MELINALMAH NMRQNLQIVV QVATKYAEQL GGKELVEVFE KFKSFDGLYF
FLGSIVNFSQ DPDLHFKYIE AATKMGQFKE VERVCRDSSV YDPVKVKEFL KESKLQDPRP
LIHVCDRYDF VEELTQYLYS NNLMKYIDVY VTKVSPQKAP IVIGKLLDLD CNEDYIKNLL
NQIAQCPVDD LCEQVEKRNR LRLLQPWLET RVAQGNTETA THNAIGKIYI TLNKDPQQFL
INNQFYDSDV VGKFCEKLDP ALAYLAYRRA GGTCDDDLVR VTTENGLFKD LARYLVERQD
LDLWGKVLVK QEEGEPESPS CRALIDQVVQ TALPETTNPD EVSTTVRAFM NAELPNELIE
LLERIVLQGT DFSTNKNLQN LLILTAIKAG KEKVMDYVNR LDNFDGPEIA RIAVGEQYQL
YEEGFVIYKK TNHNVEAIGV LLDFIKDNER AYEFADRCNE SEVWSRLAKA QLDQGEVHDS
LSAFIKANDA SSYVDVIAAA ERIDNYNELI PYLKMARNTV KEQYLDTSLI YAYAKTEKYS
DLEEFISSPN VAQIQNIGER CYDEGMYTAA KLLFQNINNN AKLAICYVRL GKFREAVDAA
TKANSVGTWK EVNYACVDVN EFRLAALCGL HIVVHPDHLE ELILHYEKRG HSTELLKLME
QGLGLEGAHA GIFTELAILY SKYMPSKLME HIKIFHSRMN VSKILRACEK GLHWDHAVYL
YKEDGQFDNA VRTMVDHPVA FSHDLFLDCI QKVRNQEIHY KAINFYLEQH PLELTRLLQV
LTPNLDHARV VHQLRKSNNL LLVVEYLKDV QKENLSAVNE ALNEILLEDE DYQALRESVD
SYENFDQISL AQKLEKHELL EFRRIAAYLY RKNKRYPQSV KLSKADKMYK DCIDCASDSD
DPELAEDILR FFVSVHDKEC FCATLFTCYK LIRPDVALEL AWRHGYTDFV MPYMIQFVKN
LNDKVKVLDE RTQTQQEPET DAQSLDPAYG MGGMQPMLAI APTAYNDPSA QYGMGMAPGM
NMALGMQPNM AMSGMQQNPY ASSQGSMGSM GSNPYGTSGY QY
//
