ID M4C2W7_HYAAE Unreviewed; 827 AA.
AC M4C2W7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Hyaloperonospora arabidopsidis (strain Emoy2) (Downy mildew agent)
OS (Peronospora arabidopsidis).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Hyaloperonospora.
OX NCBI_TaxID=559515 {ECO:0000313|EnsemblProtists:HpaP813433, ECO:0000313|Proteomes:UP000011713};
RN [1] {ECO:0000313|Proteomes:UP000011713}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Emoy2 {ECO:0000313|Proteomes:UP000011713};
RX PubMed=21148394; DOI=10.1126/science.1195203;
RA Baxter L., Tripathy S., Ishaque N., Boot N., Cabral A., Kemen E.,
RA Thines M., Ah-Fong A., Anderson R., Badejoko W., Bittner-Eddy P.,
RA Boore J.L., Chibucos M.C., Coates M., Dehal P., Delehaunty K., Dong S.,
RA Downton P., Dumas B., Fabro G., Fronick C., Fuerstenberg S.I., Fulton L.,
RA Gaulin E., Govers F., Hughes L., Humphray S., Jiang R.H., Judelson H.,
RA Kamoun S., Kyung K., Meijer H., Minx P., Morris P., Nelson J.,
RA Phuntumart V., Qutob D., Rehmany A., Rougon-Cardoso A., Ryden P.,
RA Torto-Alalibo T., Studholme D., Wang Y., Win J., Wood J., Clifton S.W.,
RA Rogers J., Van den Ackerveken G., Jones J.D., McDowell J.M., Beynon J.,
RA Tyler B.M.;
RT "Signatures of adaptation to obligate biotrophy in the Hyaloperonospora
RT arabidopsidis genome.";
RL Science 330:1549-1551(2010).
RN [2] {ECO:0000313|EnsemblProtists:HpaP813433}
RP IDENTIFICATION.
RC STRAIN=Emoy2 {ECO:0000313|EnsemblProtists:HpaP813433};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; JH598143; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M4C2W7; -.
DR STRING; 559515.M4C2W7; -.
DR EnsemblProtists; HpaT813433; HpaP813433; HpaG813433.
DR VEuPathDB; FungiDB:HpaG813433; -.
DR eggNOG; KOG3508; Eukaryota.
DR HOGENOM; CLU_009903_0_0_1; -.
DR InParanoid; M4C2W7; -.
DR OMA; CDLHSFV; -.
DR Proteomes; UP000011713; Unassembled WGS sequence.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR CDD; cd04519; RasGAP; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR10194:SF60; GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS50848; START; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011713}.
FT DOMAIN 91..365
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 581..827
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
FT REGION 9..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..511
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 827 AA; 92649 MW; 5C424C0639BF42FB CRC64;
MRALAIGLRS RARDRQKRAQ DEGHLSNASN THNKTASSSR AAGKRRPDES VRNAVAFLAQ
EDAESALVFA LVHDPEFRLA SALATVPSGA DVNVIRALLF VFEKYEDQLR KLLGLLMLRE
MVHTLNWNEL FRANSATTAL LREYTCELGG EFLQLALGDV FNKLWTESEE YEVNPRFLQP
QDDLRANQQR LELLAEYTLD CIFNAVSLFP YQIAKIYRVM ELEMVRLIER DRRSNLSLPR
FSIKGGSSNG LRVPDVGSYS NNYTEGTSAE SAGFLGALPR LSSIEENLFE EALVQSTVSN
GTVSTMTAAK EEFYMHLGGL VFLRFLCPAL VVPHKMNLTP ENAAPDNRTQ RALVLLAKLM
QSLANNVEYS PSTESYMVPF NSFLVRNRPK LTHFYDQLCL QAQNDPRRES LVARNNVAPR
LSQLWASRSS SSLGKDPSIV NLTGACIMEA PEASCAVLRN WMSSHLDYLA IEVADNNTFR
RQHQIVVSNR SSGSSCTSCT GITSPPKSTP AMITSPVKPR HRFKRMLKTS KTAAYPTEIQ
EDEDGGSSSE ILSVSQRRNH AMPVSMVELD KIMGRASHRD NQLMKVYYAK LSQNGLQRLL
NANDVDCAEW TVYRSRNDVE VLRKTPAHFL CPSGRFASEK DRLVEMKGSV IIASTPKNVF
RYLQSLDGGS TDNDNKAKIL RVEPLDDSKV VLYHQHSKLS LWPAWLVKPR DSCDLHSFVE
RTGKPDTYAV LQESVPRADV PERKGVVRMA FATGGYLIEP FVGDEEDMGF QLHGASLTRL
TCVVRADFKG LMPRYLAESI VYGRILEVEA IRSIVESMRP GTNAEWV
//
