ID   M4C421_HYAAE            Unreviewed;       350 AA.
AC   M4C421;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   RecName: Full=NAD(P)-binding domain-containing protein {ECO:0000259|Pfam:PF16363};
OS   Hyaloperonospora arabidopsidis (strain Emoy2) (Downy mildew agent)
OS   (Peronospora arabidopsidis).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Hyaloperonospora.
OX   NCBI_TaxID=559515 {ECO:0000313|EnsemblProtists:HpaP813839, ECO:0000313|Proteomes:UP000011713};
RN   [1] {ECO:0000313|Proteomes:UP000011713}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Emoy2 {ECO:0000313|Proteomes:UP000011713};
RX   PubMed=21148394; DOI=10.1126/science.1195203;
RA   Baxter L., Tripathy S., Ishaque N., Boot N., Cabral A., Kemen E.,
RA   Thines M., Ah-Fong A., Anderson R., Badejoko W., Bittner-Eddy P.,
RA   Boore J.L., Chibucos M.C., Coates M., Dehal P., Delehaunty K., Dong S.,
RA   Downton P., Dumas B., Fabro G., Fronick C., Fuerstenberg S.I., Fulton L.,
RA   Gaulin E., Govers F., Hughes L., Humphray S., Jiang R.H., Judelson H.,
RA   Kamoun S., Kyung K., Meijer H., Minx P., Morris P., Nelson J.,
RA   Phuntumart V., Qutob D., Rehmany A., Rougon-Cardoso A., Ryden P.,
RA   Torto-Alalibo T., Studholme D., Wang Y., Win J., Wood J., Clifton S.W.,
RA   Rogers J., Van den Ackerveken G., Jones J.D., McDowell J.M., Beynon J.,
RA   Tyler B.M.;
RT   "Signatures of adaptation to obligate biotrophy in the Hyaloperonospora
RT   arabidopsidis genome.";
RL   Science 330:1549-1551(2010).
RN   [2] {ECO:0000313|EnsemblProtists:HpaP813839}
RP   IDENTIFICATION.
RC   STRAIN=Emoy2 {ECO:0000313|EnsemblProtists:HpaP813839};
RG   EnsemblProtists;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. {ECO:0000256|ARBA:ARBA00007637}.
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DR   EMBL; ABWE02002914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; M4C421; -.
DR   STRING; 559515.M4C421; -.
DR   EnsemblProtists; HpaT813838; HpaP813838; HpaG813838.
DR   EnsemblProtists; HpaT813839; HpaP813839; HpaG813839.
DR   VEuPathDB; FungiDB:HpaG813838; -.
DR   eggNOG; KOG1371; Eukaryota.
DR   HOGENOM; CLU_007383_1_7_1; -.
DR   InParanoid; M4C421; -.
DR   OMA; PIKLFNH; -.
DR   Proteomes; UP000011713; Unassembled WGS sequence.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43574; EPIMERASE-RELATED; 1.
DR   PANTHER; PTHR43574:SF90; NAD(P)-BD_DOM DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF16363; GDP_Man_Dehyd; 1.
DR   PRINTS; PR01713; NUCEPIMERASE.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000011713}.
FT   DOMAIN          28..333
FT                   /note="NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF16363"
SQ   SEQUENCE   350 AA;  38839 MW;  9FFD440CABF5EC05 CRC64;
     MAPTPFEVSD VLVPVNETAA ATARRHVLVT GAAGFIGFHT AKALLARGDN VVILDELNDY
     YDVELKQSNL DWLTTTYGSR VRVYIGDICD QHLVRRVLKE TTINEVVHLA ARAGVRPSID
     NPLLYIHSNV VATMVLLDAC REFNIKKFVY ASSSSVYGGS MKDRFSETDI VDYPVSPYAA
     TKKSCELLAH TYHHLHGLDT IGLRFFTVYG PRGRPDMAPF KFMDRIARDV AIDQYGDGSS
     SRDYTYIDDI VQGVVLSLDH GHGCEVFNLG RGTPVLLTDF ISIIEGLVGK KAKIQILPDQ
     PGDVPRTSAD ISKAERLLGY KPTTSLKQGL AKTWEWYSDF YNAKLLAEVM
//