ID M4MBB3_9CAUD Unreviewed; 380 AA.
AC M4MBB3;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=VPDG_00029 {ECO:0000313|EMBL:AGG58190.1};
OS Vibrio phage henriette 12B8.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes.
OX NCBI_TaxID=573174 {ECO:0000313|EMBL:AGG58190.1, ECO:0000313|Proteomes:UP000011862};
RN [1] {ECO:0000313|EMBL:AGG58190.1, ECO:0000313|Proteomes:UP000011862}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henriette 12B8 {ECO:0000313|EMBL:AGG58190.1};
RG The Broad Institute Genome Sequencing Platform;
RA Henn M.R., Polz M., Kauffman A.K.M., Levin J., Malboeuf C., Casali M.,
RA Russ C., Lennon N., Chapman S.B., Erlich R., Young S.K., Koehrsen M.,
RA Yandava C., Zeng Q., Alvarado L., Anderson S., Berlin A., Borenstein D.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Green L.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA Rizzolo K., Roberts A., Ryan E., Saif S., Shea T., Shenoy N., Sisk P.,
RA Stolte C., Sykes S., Walk T., White J., Haas B., Nusbaum C., Birren B.;
RT "The Genome Sequence of Vibrio phage henriette 12B8.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; HQ316582; AGG58190.1; -; Genomic_DNA.
DR RefSeq; YP_007878001.1; NC_021073.1.
DR GeneID; 15312430; -.
DR KEGG; vg:15312430; -.
DR OrthoDB; 165at10239; -.
DR Proteomes; UP000011862; Genome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR Gene3D; 1.20.1280.300; -; 1.
DR Gene3D; 3.40.1820.10; DnaQ-like 3'-5' exonuclease; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000011862}.
FT DOMAIN 23..110
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 380 AA; 43706 MW; 0DAB0FC2B48C0EFA CRC64;
MIPEHDNVSM MTDDELIAYH QHHRKQAVLK NNGQLVRKIL LNSFYGSLAN VYSPLFDLRL
AESITLSGQL SIRWAGKCMN DYLNSIHKTT DVDYIIYTDT DSIYVDMEMV AQRLSNNGIN
FDINNPDDLH KVVNALDKFC QDYAEPALSR GYEEMHKYCN SYQQKMFMDR EVISDNSVFC
SKKRYMMSVW NSEGVAFDEA YIKVMGMDMV KSSTPQVVRD AMKKTANIVL NGSEQDLHTY
VKGFREKFNN LPPEAIAFPR GVNKLEETYC KPNGSFRDDV TVVINSRAAI NFNNAIKSYD
LDYPLIVNGD KIKYVHLTEP NKFQTHVFGF TDTLPKELDI HKKVDYSMML EKTYLKPMND
LVNIIGWSLE PRASIDAFFG
//
