ID M4QG88_SALSA Unreviewed; 283 AA.
AC M4QG88;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=IGF binding protein 3 precursor {ECO:0000313|RefSeq:NP_001117120.1};
DE SubName: Full=Insulin-like growth factor binding protein 2 paralog B1 {ECO:0000313|EMBL:AGH18151.1};
GN Name=IGFBP-2B1 {ECO:0000313|EMBL:AGH18151.1};
GN Synonyms=igfbp-2b1 {ECO:0000313|RefSeq:NP_001117120.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:AGH18151.1};
RN [1] {ECO:0000313|RefSeq:NP_001117120.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19043058; DOI=10.1242/jeb.024117;
RA Bower N.I., Li X., Taylor R., Johnston I.A.;
RT "Switching to fast growth: the insulin-like growth factor (IGF) system in
RT skeletal muscle of Atlantic salmon.";
RL J. Exp. Biol. 211:3859-3870(2008).
RN [2] {ECO:0000313|EMBL:AGH18151.1, ECO:0000313|RefSeq:NP_001117120.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23360665; DOI=10.1093/molbev/mst017;
RA Macqueen D.J., Garcia de la Serrana D., Johnston I.A.;
RT "Evolution of ancient functions in the vertebrate insulin-like growth
RT factor system uncovered by study of duplicated salmonid fish genomes.";
RL Mol. Biol. Evol. 30:1060-1076(2013).
RN [3] {ECO:0000313|RefSeq:NP_001117120.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR EMBL; JX565548; AGH18151.1; -; mRNA.
DR RefSeq; NP_001117120.1; NM_001123648.1.
DR STRING; 8030.ENSSSAP00000033667; -.
DR PaxDb; 8030-ENSSSAP00000033667; -.
DR GeneID; 100136551; -.
DR KEGG; sasa:100136551; -.
DR CTD; 100136551; -.
DR OrthoDB; 5394492at2759; -.
DR Proteomes; UP000087266; Chromosome ssa25.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
DR CDD; cd00191; TY; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR012210; IGFBP-2.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR022321; IGFBP_1-6_chordata.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR11551; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN; 1.
DR PANTHER; PTHR11551:SF5; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 2; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR PRINTS; PR01976; IGFBPFAMILY.
DR PRINTS; PR01978; IGFBPFAMILY2.
DR SMART; SM00121; IB; 1.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Growth factor binding {ECO:0000256|ARBA:ARBA00023183};
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001117120.1}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..283
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001117120.1"
FT /id="PRO_5009732037"
FT DOMAIN 25..106
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 177..259
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT REGION 106..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 283 AA; 31649 MW; E1F0078C516F5E5F CRC64;
MVLYFSCGLL LLMLLGLPGL SLGDLVFHCP KCTAERQTAC PELTINCTEI VREPACGCCP
VCARLEGEFC GVYTPRCSTG LRCYPTADSK LPLEQLVQGL GRCSQKVDPV PNRTQEHQGT
SEELQGTEGP TQKKLTKDVR IWILSKDQAI RQAQNELKTK MKNNNCAEEP KTQEPMKGPC
KQELEKVLEE ISKMSFHDNR GPVENLYQLK FPNCEKIGQY NLKQCHISTH GQRGECWCVN
PFTGVQIAQS TKVRGDPNCS QYVEEQEMET GTQSTTILQM AEI
//
